Synthesis of cyano derivatives of pyrimidine bases and their effect on blood leukocyte system

Пурыгин, П. П.; Kuz'mina, V. E.; Vishnyakov, V.V.

doi:10.1007/s11094-005-0055-6

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“…Heterocyclic nuclei form the basis for the construction of numerous homological series containing hydrocarbon residues in the form of side chains, as well as various functional groups. The most important are pyrrol, pyrazole, imidazole, pyridine, pyrimidine, piperidine, furan, thiophene, indole, quinoline, purine, benzimidazole, etc (Dambaeva et al 2003;Eryanti et al 2015;Holt et al 2005;Purygin et al 2004). Heterocyclic compounds include alkaloids -nitrogen-containing physiologically active substances of plants.…”

Section: Introductionmentioning

confidence: 99%

Improvement of myelopoiesis in a cyclophosphamide-induced myelodepression model by administration of a Newly Synthesized Pyrazolo- Piperidine β-Cyclodextrine complex compound

Daulet

Baktybayeva

Belyaev

et al. 2022

Preprint

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According to WHO, the acquired secondary form of hematopoietic-depressive states increases the risk of death in people with cancer, infectious, and hormonal diseases. The choice of drugs that stimulate the proliferative activity of bone marrow cells is limited. The stimulus to the search for hematopoietic-stimulating compounds among pyridine derivatives was the manifestation of the activity of the cerebroprotective drug Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) to restore the granulocytes and B-lymphocytes homeostasis in clinical practice. The hematopoietic-stimulating activity of the newly synthesized compound Complex of 5-benzyl-7-(o-fluorobenzylidene)-2,3-bis(o-fluorophenyl)-3,3a,4,5,6,7-hexahydro-2H-pyrazolo [4,3-c]pyridine complex with β-cyclodextrin (BIV) was studied on a model of cyclophosphamide-induced myelodepression in C57BL6/J mouse line. The BIV compound demonstrated a stimulating effect on the process of restoring the level of Ly-6G+ Ly-6C+ granulocytes, monocytes/macrophages, CD19+ B-lymphocytes in the bone marrow, exceeding the activity of the reference drug Methyluracil. The BIV compound did not affect on the proliferative activity of c-kit (CD117+)-expressing cells, CD3e+ pre-T-lymphocytic cells and Ter-119+ erythroid cells in the bone marrow. The total number of bone marrow myelokaryocytes in the experimental groups was significantly higher than in the intact group. The pronounced hematopoietic-stimulating effect of the BIV compound gives in the future the prospect of development as a drug used for the treatment of B-lymphocytic and granulocytic-macrophage hematopoietic-depressive states.

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Section: Introductionmentioning

confidence: 99%