X-Ray treatment of carbuncles and furuncles (boils)

Calabrese, Edward J.

doi:10.1177/0960327112467046

Cited by 32 publications

(31 citation statements)

References 44 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The highest volume of pulmonary lesions was found in the left lungs of patients No. 5 and 10, which were measured at 503.9 and 615.39 cm 3 , respectively. The lowest lesion volume was observed in the right lungs of patients No.…”

Section: Resultsmentioning

confidence: 99%

Feasibility of Treatment Planning System in Localizing the COVID-19 Pneumonia Lesions and Evaluation of Volume Indices of Lung Involvement

et al. 2020

View full text Add to dashboard Cite

Background and purpose: To assess the feasibility of a treatment planning system in localizing, contouring, and targeting lung lesions along with an evaluation of volume indices of lung involvement in patients with COVID-19 pneumonia. Methods: We evaluated 10 patients with PCR-confirmed COVID-19 pneumonia. The CT images were imported into the ISOgray® treatment planning system to anatomically define and contour the volumes of the pulmonary lesions, the lungs, and other nearby organs. Results: The ratio of lung lesion volume to lung volume in this study was 0.11 ± 0.13 (11.13%). The highest mean biosynthesis ratio of lung lesions was 0.36. The ratio of lesion volume in the left lung of patients with the highest volume of involvement, was 0.44, and the ratio of lesion volume in the right lung of these patients was 0.27 (approximately 1.5 times more in the left lung than the right lung). On average, CTDIvol and DLP for all patients studied in our study were 11.22 ± 2.47 mGy and 354.20 ± 65.11 mGy.cm Conclusion: We reported the feasibility of using a treatment planning system in localizing COVID-19 pulmonary lesions and its validity in the volumetric assessment of infected lung regions.

show abstract

Section: Resultsmentioning

confidence: 99%

Feasibility of Treatment Planning System in Localizing the COVID-19 Pneumonia Lesions and Evaluation of Volume Indices of Lung Involvement

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Long before high dose radiotherapy became a standard treatment for cancer, LDRT has been employed to treat benign diseases because of its anti-inflammatory effect. Indeed, LDRT was a popular and effective treatment for a myriad of inflammatory or infectious disease ranging from arthritis to sinusitis, ear infection, and potentially deadly infection such as pneumonia and gas gangrene [23][24][25][26][27][28][29][30]. A single treatment of 20 cGy to 200 cGy has been reported to be effective in inducing fast and lasting effects for those conditions [29].…”

Section: Pathophysiology Of Covid 19 Pneumonitismentioning

confidence: 99%

Whole-lung Low Dose Irradiation for SARS-Cov2 Induced Pneumonia in the Geriatric Population: An Old Effective Treatment for a New Disease? Recommendation of the International Geriatric Radiotherapy Group

Lara¹,

Nguyen²,

Macias-Verde³

et al. 2020

Aging and disease

View full text Add to dashboard Cite

A cytokine storm induced by SARS-Cov2 may produce pneumonitis which may be fatal for older patients with underlying lung disease. Hyper-elevation of Interleukin1 (IL-1), Tumor necrosis factor-1alfa (TNF-1 alfa), and Interleukin 6 (IL-6) produced by inflammatory macrophage M1 may damage the lung alveoli leading to severe pneumonitis, decreased oxygenation, and potential death despite artificial ventilation. Older patients may not be suitable candidates for pharmaceutical intervention targeting IL-1/6 blockade or artificial ventilation. Low dose total lung (LDTL) irradiation at a single dose of 50 cGy may stop this cytokine cascade, thus preventing, and/or reversing normal organs damage. This therapy has been proven in the past to be effective against pneumonitis of diverse etiology and could be used to prevent death of older infected patients. Thus, LDRT radiotherapy may be a cost-effective treatment for this frail patient population whom radiation-induced malignancy is not a concern because of their advanced age. This hypothesis should be tested in future prospective trials.

show abstract

“…In the following years, multiple articles were published about the great and prompt benefit to patients treated with x-rays [28]. A lower single therapeutic dose of 0.75-2 Gy showed less radiation-induced side effects and an even greater effect on pain reduction and healing, especially in early stages of the disease [29]. In the early 1940's, this x-ray therapy became obsolete due to the introduction of antibiotics.…”

Section: Soft Tissue Infections Treated With X-raymentioning

confidence: 99%

“…In the early 1940's, this x-ray therapy became obsolete due to the introduction of antibiotics. For a more detailed description of the historical role of x-ray treatment for carbuncles and furuncles we direct the reader to the review by Calabrese [29].…”

Section: Soft Tissue Infections Treated With X-raymentioning

confidence: 99%

Treating infections with ionizing radiation: a historical perspective and emerging techniques

Dijk

Lemans

Hoogendoorn

et al. 2020

Antimicrob Resist Infect Control

View full text Add to dashboard Cite

Background: Widespread use and misuse of antibiotics have led to a dramatic increase in the emergence of antibiotic resistant bacteria, while the discovery and development of new antibiotics is declining. This has made certain implant-associated infections such as periprosthetic joint infections, where a biofilm is formed, very difficult to treat. Alternative treatment modalities are needed to treat these types of infections in the future. One candidate that has been used extensively in the past, is the use of ionizing radiation. This review aims to provide a historical overview and future perspective of radiation therapy in infectious diseases with a focus on orthopedic infections. Methods: A systematic search strategy was designed to select studies that used radiation as treatment for bacterial or fungal infections. A total of 216 potentially relevant full-text publications were independently reviewed, of which 182 focused on external radiation and 34 on internal radiation. Due to the large number of studies, several topics were chosen. The main advantages, disadvantages, limitations, and implications of radiation treatment for infections were discussed. Results: In the pre-antibiotic era, high mortality rates were seen in different infections such as pneumonia, gas gangrene and otitis media. In some cases, external radiation therapy decreased the mortality significantly but longterm follow-up of the patients was often not performed so long term radiation effects, as well as potential increased risk of malignancies could not be investigated. Internal radiation using alpha and beta emitting radionuclides show great promise in treating fungal and bacterial infections when combined with selective targeting through antibodies, thus minimizing possible collateral damage to healthy tissue. Conclusion: The novel prospects of radiation treatment strategies against planktonic and biofilm-related microbial infections seem feasible and are worth investigating further. However, potential risks involving radiation treatment must be considered in each individual patient.

show abstract

X-Ray treatment of carbuncles and furuncles (boils)

Cited by 32 publications

References 44 publications

Feasibility of Treatment Planning System in Localizing the COVID-19 Pneumonia Lesions and Evaluation of Volume Indices of Lung Involvement

Feasibility of Treatment Planning System in Localizing the COVID-19 Pneumonia Lesions and Evaluation of Volume Indices of Lung Involvement

Whole-lung Low Dose Irradiation for SARS-Cov2 Induced Pneumonia in the Geriatric Population: An Old Effective Treatment for a New Disease? Recommendation of the International Geriatric Radiotherapy Group

Treating infections with ionizing radiation: a historical perspective and emerging techniques

Contact Info

Product

Resources

About