X-ray scattering study on amorphous, polynuclear platinum uridine complexes

An Improved Regularization Technique for Analysis of Anomalous X-ray Scattering Data; Platinum Uridine Blue Sulfate as an Example

“…The most important difference is that in the RDF at 17.4 keV there are separate maxima at 2, 2.6 and 3 A and in the RDF at 11.5 keV only two broad maxima at about 2 and 3 A. In the previous study (Serimaa et al, 1993), it was concluded on the basis of the total RDF that the nuclearity of Pt chains in Pt-uridine blue does not exceed four. The Pt-Pt PDF determined in this work indicates that the dominating Pt structures in Pt-uridine blue are dinuclear.…”

“…The measurements were made using synchrotron light, whereas the previous measurements (Serimaa et al, 1993) were made using a conventional X-ray source (Mo K~,, 17.4 keV). The statistical precision of the present data (10.6--11.5 keV) is better than in the previous study.…”

“…The shortest Pt-Pt distance of 2.94 A of Pt-uridine blue (Teo, Kijima & Bau, 1978) was determined for the first time by means of the extended X-ray absorption fine structure method (EXAFS). Results of our WAXS (Serimaa, Vahvaselk/i, Paakkari, Laitalainen & Oksanen, 1993) and EXAFS (Eteliiniemi, Serimaa, Paakkari & Laitalainen, 1996) studies of Pturidine blue sulfate synthesized by a newer method (Okuno, Tonosaki, Inoue, Yonemitsu & Sasaki, 1986;Serimaa et al, 1993) are comparable to those of Teo et al (1978) and suggest Pt-structures analogous to crystalline models (Barton, Rabinowitz, Szalda & Lippard, 1977;O'Halloran, Mascharak, Williams, Roberts & Lippard, 1987;Matsumoto, Takahashi & Fuwa, 1984, and references therein). The length of the Pt-chain cannot be determined unambigously from the total radial distribution function (RDF).…”

Structural study of amorphous platinum 5-fluorouridine green sulfate

“…[17][18][19][20] The present knowledge about the correlation between the structure and the chemical nature of the amorphous platinum blues is largely based on the studies of crystalline platinum pyrimidine complexes, 17,21-23 the breakthrough being the crystal structure determination of tetranuclear platinum α-pyridone blue. 24 Studies on amorphous platinum nucleoside (modified nucleosides) complexes in the solid state have been carried out by extended X-ray absorption fine structure (EXAFS), 25, 26 wide angle X-ray scattering (WAXS), [27][28][29][30][31] anomalous wide angle X-ray scattering (AWAXS), 32, 33 small angle X-ray scattering (SAXS) 34 and in solution by SAXS, 3,30,31, 35 UV/VIS spectroscopy 36-38 and 195 Pt, 15 N and 13 C NMR spectroscopy. 37,39,40 Recently the structure of platinum uridine green sulfate was studied in the solid state by AWAXS and EXAFS methods.…”

Structure of Amorphous Platinum Uridine Green Sulfate by AWAXS and EXAFS

“…Platinum pyrimidine blues , are antitumor active, amorphous and paramagnetic products formed in reactions of cisplatin or cis -diaquadiammineplatinum(II) with pyrimidine bases. In several studies, e.g., − products with varying antitumor activities, elemental compositions, and colors have been obtained. Both the detailed structures and the origin of the antitumor activity of platinum pyrimidine blues are unknown.…”