Structural study of amorphous platinum 5-fluorouridine green sulfate

Uracilato and 5-halouracilato complexes of Cu(II), Zn(II) and Ni(II). X-ray structures of [Cu(uracilato-N1)2(NH3)2]·2(H2O), [Cu(5-chlorouracilato-N1)2(NH3)2](H2O)2, [Ni(5-chlorouracilato-N1)2(en)2]·2H2O and [Zn(5-chlorouracilato-N1)(NH3)3]·(5-chlorouracilato-N1)·(H2O)

“…Moreover a 5-chloro-1-methyluracilato Pt(II) complex have been structurally characterised [20]. The pharmacological properties of 5-halouracils and some of its metal derivatives [1,3,5] have prompted us to study the co-ordination chemistry of these ligands. In the present paper several Cu(II), Zn(II) and Ni(II) complexes with uracil (ura) and 5-halouracils (X-ura) have been synthesized and characterized, and the X-ray structures of…”

“…In spite of the widespread use of these antineoplastic agents and its future potentialities, the knowledge of the coordination chemistry of 5-haloruracils is limited [1][2][3][4][5]7,8]. A great number of metal 1-methyluracilato [9] and uracilato complexes with Cd(II) [10], Ni(II) [11,12], Hg(II) [13], Pt(II) [12,14,15] and Zn(II) [16][17][18] have been described, but, to our knowledge, only an example of Xray structure of metal complexes with 5-halouracilatos is known: the [Cu(5-fluorouracilato-N 1 ) 2 (NH 3 ) 2 (H 2 O)] complex, where the metal is bound to 5-fluorouracilato via N 1 in a limit 4 + 1 square-pyramidal coordination [7].…”

“…Combined chemotherapy with cis-platin and 5-fluorouracil is a standard therapy for the treatment of certain types of cancer [1][2][3][4][5].…”

On the importance of antiparallel C O⋯C–F interactions in N1-(3-hydroxypropyl)-5-fluorouracilate–Hg(II) complex: A combined X-ray and DFT study

“…N 1 -(3-hydroxypropyl)-5-fluorouracil. It should be mentioned that 5-fluorouracil is particularly interesting because it is used in combination with cisplatin against some cancer types [15][16][17][18][19]. Moreover, 5-fluorouracil and some N 1 -alkyl derivatives, for instance N 1 -(2-hydroxyethyl)-5-fluorouracil, are natural products that have been isolated from the marine sponge Phakellia fusca [20][21].…”