X-ray-responsive selenium nanoparticles for enhanced cancer chemo-radiotherapy

Yu, Bo; Liu, Ting; Du, Yutong; Luo, Zuandi; Zheng, Wenjie; Chen, Tianfeng

doi:10.1016/j.colsurfb.2015.11.063

Cited by 93 publications

(49 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, higher doses of selenium may be toxic for both normal and malignant cells . Similar results were observed for selenium nanocomposites . A study showed that selenium has a synergic effect on the response of rat's glioma cells to ionizing radiation.…”

Section: Synergic Effects Of Selenium In Cancer Response To Radiationmentioning

confidence: 64%

Selenium as an adjuvant for modification of radiation response

Farhood

Mortezaee

Motevaseli

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

Ionizing radiation plays a central role in several medical and industrial purposes. In spite of the beneficial effects of ionizing radiation, there are some concerns related to accidental exposure that could pose a threat to the lives of exposed people. This issue is also very critical for triage of injured people in a possible terror event or nuclear disaster. The most common side effects of ionizing radiation are experienced in cancer patients who had undergone radiotherapy. For complete eradication of tumors, there is a need for high doses of ionizing radiation. However, these high doses lead to severe toxicities in adjacent organs. Management of normal tissue toxicity may be achieved via modulation of radiation responses in both normal and malignant cells. It has been suggested that treatment of patients with some adjuvant agents may be useful for amelioration of radiation toxicity or sensitization of tumor cells. However, there are always some concerns for possible severe toxicities and protection of tumor cells, which in turn affect radiotherapy outcomes. Selenium is a trace element in the body that has shown potent antioxidant and radioprotective effects for many years. Selenium can potently stimulate antioxidant defense of cells, especially via upregulation of glutathione (GSH) level and glutathione peroxidase activity. Some studies in recent years have shown that selenium is able to mitigate radiation toxicity when administered after exposure. These studies suggest that selenium may be a useful radiomitigator for an accidental radiation event. Molecular and cellular studies have revealed that selenium protects different normal cells against radiation, while it may sensitize tumor cells. These differential effects of selenium have also been revealed in some clinical studies. In the present study, we aimed to review the radiomitigative and radioprotective effects of selenium on normal cells/tissues, as well as its radiosensitive effect on cancer cells.

show abstract

Section: Synergic Effects Of Selenium In Cancer Response To Radiationmentioning

confidence: 64%

Selenium as an adjuvant for modification of radiation response

Farhood

Mortezaee

Motevaseli

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

“…For instance, combining Si NP and 4 MeV X-rays, a 700% increase in DCF fluorescence was achieved in C6 glioma cells after 3 Gy (Gara et al, 2012). An increase in intracellular ROS content was also shown for SPION (Klein et al, 2012), nanodiamonds (Grall et al, 2015), AGuIX ® (Miladi et al, 2015) and selenium NP (Yu et al, 2016). The first difficulty is that ROS quantification in cells with usual fluorescent probes such as H 2 DCFDA and its derivatives do not discriminate different kinds of radicals, hydroxyl or superoxide for example, contrary to what is done in vitro, coumarin being a specific scavenger of HO • .…”

Section: Which Connection Between Physical and Biological Effect Of Np?mentioning

confidence: 87%

Actual questions raised by nanoparticle radiosensitization

Brun

Sicard-Roselli

2016

Radiation Physics and Chemistry

View full text Add to dashboard Cite

“…The Se treatment was thus active against cancer, greatly increasing the pro-oxidant baseline status. Se nanoparticles have been shown to be able to potentiate radiotherapy, and again at doses increasing the production of ROS in the cancer cells (21). Cancer cells already have a pro-oxidant status compared with normal cells and it is by further increasing the production of ROS that chemotherapeutic agents usually kill them (6).…”

Section: Discussionmentioning

confidence: 99%

Negative Impact of Total Body Irradiation on the Antitumor Activity of Rhenium-(I)-diselenoether

Collery¹,

Santoni

Mohsen

et al. 2016

View full text Add to dashboard Cite

Abstract. It has been shown that a rhenium-(I)-It has been shown that a prolonged oral administration of amphiphilic rhenium-(I)-diselenoether complex allowed a dose-dependent uptake of the two major components of this drug, rhenium (Re) and selenium (Se) in healthy tissues, with highest uptake by the liver (1). Assays of these two elements have not yet been performed in tumorsThe combination of Se with a metal has already been described, with nickel as the metal (2). In that case, the presence of Se in the active site of hydrogenase enhanced its enzymatic property. Selective incorporation of Se into the active site of the molybdenum-iron (Mo-Fe) protein is essential for the catalytical effect of nitrogenase (3). Ironselenium ferredoxin with two clusters [4Fe-4Se] is present in the active site of a hydrogenase (4), with the same role as the iron-sulfur ferredoxin as a two-electron carrier.It is known that Re is able to bind DNA reversibly and that Re is found in the nucleus of malignant cells after the administration of Re-diselenoether (1, 5). It was also shown that the Re-diselenoether formed mono-adducts and bisadducts with a methyl-guanine, but also liberated the weakly chelating diselenoether ligand [supplementary material in (5)].Therefore we can hypothesize that while the Re core will have a role by interacting with DNA guanine bases, the diselenoether ligand will take Se to other targets.The anticancer activity of Re-diselenother has been demonstrated in experimental models of resistant triplenegative breast tumors (MDA-MB231), in malignant cells in culture, as well as after oral (5) or intraperitoneal administration (6) to tumor-bearing mice, at a daily dose of 10 mg/kg/day for 4 weeks, which was safe for the animals. The Re-diseleno ether compound we used, constituted an original chemical combination, and we aimed to complete the investigation of its biological role in an experimental model of cancer.The aim of this experiment was to test a lower dose of 5 mg/kg and to compare it with a 10-mg/kg dose. We evaluated the Re-complex as a single agent and in combination with paclitaxel, considered as a standard 5813

show abstract

X-ray-responsive selenium nanoparticles for enhanced cancer chemo-radiotherapy

Cited by 93 publications

References 36 publications

Selenium as an adjuvant for modification of radiation response

Selenium as an adjuvant for modification of radiation response

Actual questions raised by nanoparticle radiosensitization

Negative Impact of Total Body Irradiation on the Antitumor Activity of Rhenium-(I)-diselenoether

Contact Info

Product

Resources

About