X-ray Phase Contrast Imaging from Synchrotron to Conventional Sources: A Review of the Existing Techniques for Biological Applications

Quénot, Laurène; Bohic, Sylvain; Brun, Emmanuel

doi:10.3390/app12199539

Cited by 14 publications

(11 citation statements)

References 65 publications

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“…-Methods with optics, sensitive to the first derivative of the phase shift, i.e. to the refraction angle distribution Θ(x,y) ~ λ/2π ∇⊥[∫δ(x,y,z)dz] [6]. Among these methods, microgrid or mask methods are most frequently used for medical applications, because they can work with the broad X-ray spectra and the large spot sizes of medical X-ray tubes.…”

Section: Ii)mentioning

confidence: 99%

“…Lastly, an absorption grid is placed at the detector to transform the pattern changes into intensity changes, or alternately, the pattern changes are directly recorded by the detector. The grid methods include: Talbot-Lau or Talbot grating interferometry, the Edge Illumination (EI) method, and tracking methods (see [6,7] for recent reviews of these methods).…”

Section: Ii)mentioning

confidence: 99%

“…Fig. 8a shows the computed refraction images for three values of the X-ray fluence at the object: 3x10 7 , 3x10 6 , and 3x10 5 photons/mm 2 , corresponding to 2 mGy (the typical mammography dose), 0.2 mGy, and 0.02 mGy, respectively. We assumed phase-stepping with 10 steps in one period, and divided the total fluence in equal fractions per step (e.g., 3x10 5 photons/mm 2 for each step of the 0.2 mGy simulation).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Towards high-sensitivity and low-dose medical imaging with laser x-ray sources

Stutman

Safca

Tomassini

et al. 2023

Compact Radiation Sources From EUV to Gamma-Rays: Development and Applications

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Phase contrast X-ray imaging can be much more sensitive to soft tissue lesions than conventional absorption contrast X-ray imaging, being a potential game changer for medical imaging. A phase contrast method well suited for clinical implementation is the grating interferometry. We show that by using μm period multi-meter long interferometers one can strongly increase the phase sensitivity and lower the dose towards soft tissue imaging applications such mammography. Conventional X-ray tubes do not provide, however, sufficient X-ray flux for clinical imaging with such long interferometers. Instead, 100-TW class lasers could produce highly directional and intense X-ray sources ideal for high sensitivity medical interferometry. We present the X-ray source characteristics required for clinical interferometry, advantages and disadvantages of betatron versus inverse Compton scattering sources for clinical application, and some practical considerations towards laser based interferometric medical imaging.

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Section: Ii)mentioning

confidence: 99%

Section: Ii)mentioning

confidence: 99%

mentioning

confidence: 99%

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Towards high-sensitivity and low-dose medical imaging with laser x-ray sources

Stutman

Safca

Tomassini

et al. 2023

Compact Radiation Sources From EUV to Gamma-Rays: Development and Applications

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“…Speckle-based imaging (SBI) is an X-ray phase-contrast imaging (XPCI) technique that enables the measurement of phase and dark-field signals, in addition to conventionally accessible absorption signals [1,2]. SBI uses random wavefront modulators, such as sandpaper, to produce a reference speckle pattern at the detector plane.…”

Section: Introductionmentioning

confidence: 99%

Speckle-based imaging (SBI) applications with spectral photon counting detectors at the newly established OPTIMATO (OPTimal IMAging and TOmography) laboratory

Trapani,

Savatović,

Marco

et al. 2024

J. Inst.

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Speckle-based imaging (SBI) is an advanced X-ray imaging technique that measures phase and dark-field signals, in addition to absorption signals. SBI uses random wavefront modulators to generate speckles and requires two images: one with a speckle pattern alone, and one with both the sample and speckles. SBI reconstruction algorithms retrieve three signals (transmission, refraction, and dark-field) by comparing the two images. In SBI, speckle visibility plays a crucial role in the retrieval of the three signals. When translating the technique from synchrotron sources to compact laboratory setups, the reduced coherence of the source and limitations in the available resolution yield lower speckle visibility, hampering the retrieval of phase and dark-field signals. In this context, direct-detection CdTe X-ray photon-counting detectors (XPCDs) provide an attractive solution, as they allow for a high detection efficiency and optimal spatial resolution enhancing speckle visibility. In this work, we present the newly established OPTIMATO (OPTimal IMAging and TOmography) laboratory for X-ray imaging hosted at the Elettra synchrotron (Trieste, Italy). The setup for SBI with resolutions up to 15 µm including an XPCD and a charge-integrating flat-panel detector (FPD) has been used to acquire SBI data. The main limiting factors when moving SBI applications from synchrotron facilities to compact laboratory setups are summarized. The advantages of XPCDs over FPDs are discussed by comparing the SBI images obtained using both detectors. The potential of the spectral decomposition approach via multi-threshold acquisitions using XPCDs is briefly introduced. The results shown in this work represent the first step toward the realization of a multimodal and multiresolution X-ray facility.

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“…It can be performed with commonly available X-ray sources because of the relaxed requirements of the X-ray source [7]. While EI-XPCI is steadily developing towards industrial implementation, it remains a challenge to merge the additional components needed for EI-XPCI with existing XCT systems used in industrial and pre-clinical imaging [8]. To our knowledge, EI-XPCI is not yet performed with an existing XCT system.…”

Section: Introductionmentioning

confidence: 99%

Adapting an XCT-scanner to enable edge illumination X-ray phase contrast imaging

Huyge¹,

Vanthienen²,

Six³

et al. 2023

eJNDT

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Conventional X-ray computed tomography (XCT) is a non-destructive imaging technique to visualize and inspect the internal structure of materials in 3D, where materials are distinguished solely on the basis of their attenuation coefficient. However, with more specialized X-ray phase contrast imaging methods, sensitivity to complementary contrasts can be achieved, namely phase contrast and dark field contrast. Edge illumination X-ray phase contrast imaging (EI-XPCI) is a technique that is especially suited for laboratory application, because it has no strict coherence requirements for the source. While there is a wide variety of XCTscanners available on the market, a commercial EI-XPCI scanner does not yet exist. In this work, we present the procedure of outfitting an existing XCT-scanner with components to enable EI-XPCI scans and discuss the alignment procedure of these added components. Finally, phase contrast images are shown demonstrating the successful upgrade of a conventional XCT system with edge illumination based phase contrast possibilities.

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X-ray Phase Contrast Imaging from Synchrotron to Conventional Sources: A Review of the Existing Techniques for Biological Applications

Cited by 14 publications

References 65 publications

Towards high-sensitivity and low-dose medical imaging with laser x-ray sources

Towards high-sensitivity and low-dose medical imaging with laser x-ray sources

Speckle-based imaging (SBI) applications with spectral photon counting detectors at the newly established OPTIMATO (OPTimal IMAging and TOmography) laboratory

Adapting an XCT-scanner to enable edge illumination X-ray phase contrast imaging

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