X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations

Kaščáková, Slávka; Giuliani, Alexandre; Lacerda, Sara; Pallier, Agnès; Mercère, Pascal; Tóth, Éva; Réfrégiers, Matthieu

doi:10.1007/s12274-015-0747-5

Cited by 76 publications

(28 citation statements)

References 40 publications

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“…Recently, several types of nanoparticles have been developed for this purpose, such as metal-organic frameworks, 124 gold nanoclusters, 125 radioluminescent nanophosphors, 126, 127 QDs, 128 and lanthanide-based NPs. 129, 130 The emission of UV/visible light can be subsequently harvested by nearby PSs to generate ROS ( Fig. 6B ).…”

Section: Depth Penetrationmentioning

confidence: 99%

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment.

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Section: Depth Penetrationmentioning

confidence: 99%

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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“…Clement et al () conjugated CeF 3 nanoparticles with Verteporfin and assessed both 1 O 2 generation and lethality against Panc1 cells at low and high energies. Kaščáková et al () synthesized lanthanide‐based micelles (GdEuC12) and incorporated Hypercin into them. They observed 1 O 2 production and cytotoxicity with the formulation upon X‐ray irradiation.…”

Section: X‐ray‐induced Pdtmentioning

confidence: 99%

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Cline

Delahunty

Xie

2018

WIREs Nanomed Nanobiotechnol

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Photodynamic therapy (PDT) has emerged as an attractive option for cancer treatment. However, conventional PDT is activated by light that has poor tissue penetration depths, limiting its applicability in the clinic. Recently the idea of using X-ray sources to activate PDT and overcome the shallow penetration issue has garnered significant interest. This can be achieved by external beam irradiation and using a nanoparticle scintillator as transducer. Alternatively, research on exploiting Cherenkov radiation from radioisotopes to activate PDT has also begun to flourish. In either approach, the most auspicious success is achieved using nanoparticles as either a scintillator or a photosensitizer to mediate energy transfer and radical production. Both X-ray induced PDT (X-PDT) and Cherenkov radiation PDT (CR-PDT) contain a significant radiation therapy (RT) component and are essentially PDT and RT combination. Unlike the conventional combination, however, in X-PDT and CR-PDT, one energy source simultaneously activates both processes, making the combination always in synchronism and the synergy potential maximized. While still in early stage of development, X-PDT and CR-PDT address important issues in the clinic and hold great potential in translation. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

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“…33 This unique therapy, first described by Chen and coworkers, 34 relies on activation of scintillation nanoparticles by x-rays to produce optical emission that activates photosensitizers, which in turn produce cytotoxic ROS. Subsequently, many lanthanide-based nanoparticles for x-ray induced PDT have been reported, including lanthanide-based micelles integrated with hypericin, 35 as well as a porphyrin-conjugated Tb 2 O 3 nanoparticles. 36 Energy transfer between the nanoscintillator and the porphyrin was demonstrated under UV excitation for the porphyrin-nanoparticle conjugate, while the yield of 1 O 2 increased with longer X-ray irradiation times.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Lanthanides: Applications in Cancer Diagnosis and Therapy

2016

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Lanthanide complexes are of increasing importance in cancer diagnosis and therapy, owing to the versatile chemical and magnetic properties of the lanthanide-ion 4f electronic configuration. Following the first implementation of gadolinium(III)-based contrast agents in magnetic resonance imaging in the 1980s, lanthanide-based small molecules and nanomaterials have been investigated as cytotoxic agents and inhibitors, in photodynamic therapy, radiation therapy, drug/gene delivery, biosensing, and bioimaging. As the potential utility of lanthanides in these areas continues to increase, this timely perspective of current applications will be useful to medicinal chemists and other investigators interested in the latest developments and trends in this emerging field.

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X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations

Cited by 76 publications

References 40 publications

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Lanthanides: Applications in Cancer Diagnosis and Therapy

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