X-ray fluorescence in the assessment of inter-elemental interactions in rat liver following lead treatment

Abstract

Energy dispersive X-ray fluorescence technique was employed to study the interactions of lead (50 and 100 mg/kg body wt) with K, Fe, Cu, Zn, Br and Rb in rat liver. Lead was administered orally to rats daily for dosage periods of 1 and 4 months (short and long terms). Hepatic Fe levels were found to increase significantly with the supplementation of low and high doses of lead for both the treatment periods, although the increase was more pronounced following long-term treatment. The levels of hepatic K, Cu and Br were seen to decrease significantly over both time intervals. Moreover, hepatic Rb contents were lowered with the short-term supplementation of low doses of lead. In contrast, Rb and Zn levels were increased when lead was administered for the longer period at both dose levels.

Hepatoprotective Role of Zinc in Lead-Treated, Protein-Deficient Rats

“…Degeneration of liver, inflammation of portal areas, connective tissue hardening, clumping of nuclei in liver cells, and necrosis of liver are some of the manifestations of lead toxicity (Flanagan et al, 1979). Lead treatment in acute and chronic doses has also been shown to induce biochemical alterations thereby resulting in liver necrosis (Dhawan et al, 1982;Dhawan et al, 1995;Raymond et al, 1974;Singh et al, 1992).…”

Effect of lithium on thyroidal 131 iodine uptake, its clearance, and circulating levels of triiodothyronine and thyroxine in lead-treated rats

“…Dhawan et al [23] showed that lithium treatment may enhance the retention of 131 I in the rat thyroid. The effect of lead and lithium, separately and in combination, on the levels of essential and non-essential elements in rat blood, liver and brain have been reported elsewhere [24,25,26,27].…”

Investigation of the effect of cadmium, selenium and zinc supplementation in broiler feed on productive and biochemical parameters

“…There are many examples of lead-copper interactions in the scientific literature shown through various experiments. In experimental studies in mice, administration of a high-lead diet has been reported to lead to a deficiency in copper absorption (Dhawan et al, 1995), and conversely adding copper to the diet has been found to increase lead accumulation (Cerkleroski and Forbes, 1977). Conflicting results have been obtained in cattle studies.…”