X-ray-activated persistent luminescence nanomaterials for NIR-II imaging

Pei, Peng; Chen, Ying; Sun, Chia‐Chung; Fan, Yong; Yang, Yanmin; Li, Xuan; Lu, Lingfei; Zhao, Mengyao; Zhang, Hongxin; Zhao, Dongyuan; Liu, Xiaogang; Zhang, Fan

doi:10.1038/s41565-021-00922-3

Cited by 374 publications

(268 citation statements)

References 51 publications

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“…To make full use of PLNPs for in vivo biosensing and bioimaging, the main strategy is to modulate trap types, depths and concentrations by changing the crystal structure of the host material. [20,70] At present, researchers mainly use rare earth ion doping and other methods to achieve defect regulation of PLNPs. [71][72] All in all, defect plays a crucial role in PersL.…”

Section: Surface Defects Passivationmentioning

confidence: 99%

Defect Luminescence Based Persistent Phosphors—From Controlled Synthesis to Bioapplications

Tan

Yuan

2021

Chin. J. Chem.

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Persistent luminescence is an optical phenomenon where solid phosphors can store photoenergy in defects and release the energy by luminescence after stopping excitation. Due to the intriguing optical characteristics, the defect luminescence based persistent phosphors have attracted enormous attention in recent decades, especially in biomedical fields such as biosensing and bioimaging. Persistent luminescence nanoparticles (PLNPs) can effectively avoid the autofluorescence interference from complex samples or tissues, leading to significantly improved sensitivity in biological analysis. In this review, we summarized the methods to control the optical performance of PLNPs from the perspectives of controlled synthesis and defect regulation, and emphasized the close relationship between their optical performance and applications. We further provided a summary about a series of PLNPs nanoprobes designed by our group for biosensing and bioimaging. Our efforts, summarized in this review, will not only open a window for manipulating luminescence in PLNPs, but also further promote the application of PLNPs in biomedicine. What is the most favorite and original chemistry developed in your research group?Synthesis and bioapplications of persistent phosphors.How do you get into this specific field? Could you please share some experiences with our readers?I got into chemistry related to biomedicine during my graduate student period. The research situation of luminescent nanomaterials in China has a strong effect on me, inspiring me to pursuit new luminescent nanomaterials and their applications.We need have interest and concentrate on our research with passion. We are encouraged to work hard.What is the most important personality for scientific research?Curiosity and hard‐working.What are your hobbies? What's your favorite book(s)?Shopping and reading books. My favorite books are novels, such as “The Three‐Body Problem”.How do you keep balance between research and family?I have two boys and it takes me much time to take care of them. I need to elevate my work efficiency and work hard. I also buy household service to save time.Who influences you mostly in your life?My father. He loves reading and writing. I know one need to have passion on something under my father's influence.

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Section: Surface Defects Passivationmentioning

confidence: 99%

Defect Luminescence Based Persistent Phosphors—From Controlled Synthesis to Bioapplications

Tan

Yuan

2021

Chin. J. Chem.

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“…However, works of STORM based on lanthanide-doped nanoparticles have not been reported so far. This is mainly due to the fact that fluorescent probes applied in STORM must be able to be stochastically switched between a fluorescent and a nonfluorescent status at a single-molecule level, which is attributed to fluorophore blinking in the presence of excitation light (Bates et al, 2005;Huang et al, 2008), while lanthanide-doped nanoparticles exhibit excellent photostability and non-photobleaching Pei et al, 2021), resulting in a big barrier for using lanthanide-doped nanoparticles in STORM. In addition to this, STORM establishes an on and off state at the single-molecule level so that the theoretical optical resolution of STORM may be below 1 nm (Bates et al, 2008;Li and Vaughan, 2018), which is much less than the particle size of the lanthanide-doped nanoparticles with bright luminescence (Zhang et al, 2020;Zhao et al, 2020).…”

Section: Challenges and Outlookmentioning

confidence: 99%

Super-Resolution Imaging With Lanthanide Luminescent Nanocrystals: Progress and Prospect

Zhao

Ábrahám

Zhang

2021

Front. Bioeng. Biotechnol.

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Stimulated emission depletion (STED) nanoscopy has overcome a serious diffraction barrier on the optical resolution and facilitated new discoveries on detailed nanostructures in cell biology. Traditional fluorescence probes employed in the super-resolution imaging approach include organic dyes and fluorescent proteins. However, some limitations of these probes, such as photobleaching, short emission wavelengths, and high saturation intensity, still hamper the promotion of optical resolution and bio-applications. Recently, lanthanide luminescent probes with unique optical properties of non-photobleaching and sharp emissions have been applied in super-resolution imaging. In this mini-review, we will introduce several different mechanisms for lanthanide ions to achieve super-resolution imaging based on an STED-like setup. Then, several lanthanide ions used in super-resolution imaging will be described in detail and discussed. Last but not least, we will emphasize the future challenges and outlooks in hope of advancing the next-generation lanthanide fluorescent probes for super-resolution optical imaging.

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“…In spite of these attractive points, the previous literatures focus mainly on visible PersL of the trivalent lanthanides. To achieve PersL in the UV or even deep UV and NIR range is still a challenge, although there has been some related work 17 – 20 . Moreover, there are other problems such as how to tailor the intensity of PersL, how to obtain desirable excitation and emission bands, and so forth.…”

Section: Introductionmentioning

confidence: 99%

“…Although these models could explain some observed phenomena, there are flaws for these models and some key points still remain unclear. It is difficult to put forward a universal mechanism to reasonably explain all experimental results, and here we mainly focus on the PersL of the trivalent lanthanides in wide bandgap hosts due to its extensive application value 20 .…”

Section: Introductionmentioning

confidence: 99%

Mechanism of the trivalent lanthanides’ persistent luminescence in wide bandgap materials

et al. 2022

Light Sci Appl

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The trivalent lanthanides have been broadly utilized as emitting centers in persistent luminescence (PersL) materials due to their wide emitting spectral range, which thus attract considerable attention over decades. However, the origin of the trivalent lanthanides’ PersL is still an open question, hindering the development of excellent PersL phosphors and their broad applications. Here, the PersL of 12 kinds of the trivalent lanthanides with the exception of La3+, Lu3+, and Pm3+ is reported, and a mechanism of the PersL of the trivalent lanthanides in wide bandgap hosts is proposed. According to the mechanism, the excitons in wide bandgap materials transfer their recombination energy to the trivalent lanthanides that bind the excitons, followed by the generation of PersL. During the PersL process, the trivalent lanthanides as isoelectronic traps bind excitons, and the binding ability is not only related to the inherent arrangement of the 4f electrons of the trivalent lanthanides, but also to the extrinsic ligand field including anion coordination and cation substitution. Our work is believed to be a guidance for designing high-performance PersL phosphors.

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X-ray-activated persistent luminescence nanomaterials for NIR-II imaging

Cited by 374 publications

References 51 publications

Defect Luminescence Based Persistent Phosphors—From Controlled Synthesis to Bioapplications

Defect Luminescence Based Persistent Phosphors—From Controlled Synthesis to Bioapplications

Super-Resolution Imaging With Lanthanide Luminescent Nanocrystals: Progress and Prospect

Mechanism of the trivalent lanthanides’ persistent luminescence in wide bandgap materials

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