X-ray-activated nanosystems for theranostic applications

Chen, Xiaofeng; Song, Jibin; Chen, Xiaoyuan; Yang, Huanghao

doi:10.1039/c8cs00921j

Cited by 274 publications

(194 citation statements)

References 214 publications

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…One strategy uses nanosensitizers that contain scintillators and photosensitizers to activate PDT and radiation therapy (RT) concurrently with the same ionizing irradiation. [ 3 ] This procedure is called X‐ray‐induced photodynamic therapy, viz., X‐PDT. [ 4 ]…”

Section: Methodsmentioning

confidence: 99%

Gadolinium–Rose Bengal Coordination Polymer Nanodots for MR‐/Fluorescence‐Image‐Guided Radiation and Photodynamic Therapy

et al. 2020

Self Cite

View full text Add to dashboard Cite

Combination therapy based on nanomedicine has gained momentum in oncology in recent years, offering superior safety and efficacy over monotherapies. It is critical to design theranostics that are composed of imaging and therapeutic agents already approved. Herein, gadolinium (Gd)–rose bengal coordination polymer nanodots (GRDs) are reported. The GRDs exhibit a unique absorption property and 7.7‐fold luminescence enhancement, as well as a 1.9‐fold increase in singlet oxygen generation efficiency over free rose bengal. Meanwhile, GRDs exhibit a twofold increase in r1 relaxivity over gadopentetic acid (Gd‐DTPA) and have better X‐ray absorption ability than rose bengal alone. These excellent properties of the GRDs are verified both in vitro and in vivo. The combination of photodynamic therapy (PDT) and radiation therapy (RT) more significantly inhibits tumor growth than monotherapies (i.e., PDT or RT). This work offers a new route to designing and synthesizing Gd‐based nanotheranostics for image‐guided cancer therapy.

show abstract

Section: Methodsmentioning

confidence: 99%

Gadolinium–Rose Bengal Coordination Polymer Nanodots for MR‐/Fluorescence‐Image‐Guided Radiation and Photodynamic Therapy

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The use of X-ray as the light source is most suitable for activating the Au NCs for deep-tissue cancer treatment and biomedical imaging applications, due to its nearly unlimited penetration depth in living tissues and organisms. An interesting review, 99,100 as well as various other recent publications [101][102][103] covering the applications of Au NCs as radiosensitizers are available.…”

Section: Basic Principle Of Photosensitization For Pdtmentioning

confidence: 99%

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

2020

View full text Add to dashboard Cite

show abstract

“…Materials with X-ray luminescence are highly advantageous in improving the problem of auto-fluorescence and tissue penetration depth in vivo. 17 However, most of the organic luminescent materials show poor absorption to X-ray, let alone the emission. According to the X-ray attenuation formula, molecules with high atomic number usually have strong absorption to X-ray, which can be used as CT imaging and X-ray luminescence imaging.…”

Section: Resultsmentioning

confidence: 99%

“…25 Furthermore, since X-ray computed tomography had been widely used in clinic for imaging the anatomy, luminogens with X-ray luminescence thus are advantageous for dual-modal X-ray/X-ray excited fluorescence imaging wherein optical signal and anatomical information was simultaneously obtained. 17 Therefore, it is highly advantageous to develop X-ray excitable AIEgens, which potentially integrated both the advantages of AIEgens and X-ray excitation and possibly open a new door for fluorescence imaging in bio-applications. Platium (II) salts have been widely investigated as luminescent materials for optoelectronics and bio-imaging applications.…”

Section: Introductionmentioning

confidence: 99%

A X-ray Excitable Vibrational AIE System Based on Platinum (II) Salts

Zhao

Wang²,

Tavakoli³

et al. 2019

Preprint

View full text Add to dashboard Cite

Aggregation-induced emission luminogen excited by X-ray is highly advantageous for imaging and diagnosis but has not been achieved. Herein, we demonstrated BaPt(CN)4 as the first inorganic salt based AIE system which can be excited by X-ray. The AIE mechanism of BaPt(CN)4 is studied and the X-ray luminescence of BaPt(CN)4 is tested.understanding the unconventional clusteroluminescence of some non-conjugated luminescent system. More importantly, we found BaPt(CN)4 can be excited by X-ray, which fundamentally is highly significant since it can overcome the excitation limitation resulted auto-fluorescence and poor tissues penetration depth of AIEgens. To the best of our knowledge, this is the first reported AIEgen which could be excited by X-ray. The current work possibly opens a new door for AIE research.

show abstract

X-ray-activated nanosystems for theranostic applications

Abstract: We systematically provide an overview of X-ray-sensitive materials and the recent progress on X-ray-activated nanosystems for cancer-associated theranostic applications.

Cited by 274 publications

References 214 publications

Gadolinium–Rose Bengal Coordination Polymer Nanodots for MR‐/Fluorescence‐Image‐Guided Radiation and Photodynamic Therapy

Gadolinium–Rose Bengal Coordination Polymer Nanodots for MR‐/Fluorescence‐Image‐Guided Radiation and Photodynamic Therapy

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

A X-ray Excitable Vibrational AIE System Based on Platinum (II) Salts

Contact Info

Product

Resources

About