2012
DOI: 10.1073/pnas.1210787109
|View full text |Cite
|
Sign up to set email alerts
|

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

Abstract: Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the repressive H3K27me3 modification play an important role in the activation of "bivalent" genes in response to specific developmental cues. To determine the requirements for UTX in pluripotency and development, we have generated Utxnull ES cells and mutant mice. The loss of UTX had a profound effect … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

15
193
1

Year Published

2016
2016
2023
2023

Publication Types

Select...
5
3

Relationship

0
8

Authors

Journals

citations
Cited by 181 publications
(209 citation statements)
references
References 41 publications
(42 reference statements)
15
193
1
Order By: Relevance
“…UTX (also called KDM6A) is a Jumonji C domain-containing demethylase that removes the repressive histone mark trimethylated histone 3 Lys27 (H3K27me3) (Agger et al 2007;Hong et al 2007). Previous studies have shown that UTX plays important roles in embryonic development Welstead et al 2012) and adult hematopoiesis (Thieme et al 2013). Our identification of an interaction between TAL1 and UTX ( Fig.…”
Section: Resultsmentioning
confidence: 88%
“…UTX (also called KDM6A) is a Jumonji C domain-containing demethylase that removes the repressive histone mark trimethylated histone 3 Lys27 (H3K27me3) (Agger et al 2007;Hong et al 2007). Previous studies have shown that UTX plays important roles in embryonic development Welstead et al 2012) and adult hematopoiesis (Thieme et al 2013). Our identification of an interaction between TAL1 and UTX ( Fig.…”
Section: Resultsmentioning
confidence: 88%
“…Moreover, UTX deletion results in failure of ESCs to differentiate into the cardiac lineage [92,93]. Similarly, Jmjd3 knockout ESCs fail to differentiate into mesoderm and cardiac lineages [94].…”
Section: Histone Methyltrasnferases Are Required For Cardiomyocyte Prmentioning
confidence: 99%
“…Similarly, Jmjd3 knockout ESCs fail to differentiate into mesoderm and cardiac lineages [94]. Global genetic deletion of Utx results in embryonic lethality by E13.5 with developmental abnormalities in cardiac chamber formation [92,93]. Jmjd3 homozygous knockout mice die before E6.5 [94].…”
Section: Histone Methyltrasnferases Are Required For Cardiomyocyte Prmentioning
confidence: 99%
“…Studies have shown that Utx histone demethylase function is directed by core cardiac specific TFs, such as Nkx2.5, Gata4 and Tbx5, to the enhancer regions of cardiac genes, which leads to the transcriptional activation of their target genes during cardiac differentiation (Lee et al, 2012). Moreover, Utx deletion results in failure of ESCs to differentiate into the cardiac lineage (Lee et al, 2012;Welstead et al, 2012). Similarly, Jmjd3 knockout ESCs fail to differentiate into mesoderm and cardiac lineages (Ohtani et al, 2013).…”
Section: Ubiquitously Transcribed Tetratricopeptide Repeat X Chromosmentioning
confidence: 99%
“…Utx results in embryonic lethality by E13.5 with developmental abnormalities in cardiac chamber formation (Lee et al, 2012;Welstead et al, 2012). Jmjd3 homozygous knockout mice die before E6.5 (Ohtani et al, 2013).…”
Section: Global Genetic Deletion Ofmentioning
confidence: 99%