2016
DOI: 10.1016/j.semcdb.2015.12.021
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Abstract: In contrast to adults, recent evidence suggests that neonatal mice are able to regenerate following cardiac injury. This regenerative capacity is reliant on robust induction of cardiomyocyte proliferation, which is required for faithful regeneration of the heart following injury. However, cardiac regenerative potential is lost as cardiomyocytes mature and permanently withdraw from the cell cycle shortly after birth. Recently, a handful of factors responsible for the regenerative disparity between the adult and… Show more

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Cited by 22 publications
(13 citation statements)
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References 136 publications
(215 reference statements)
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“…Potential genomic imbalance caused by breakage of chromosome bridges in binucleated CMs could constitute a barrier to proliferation. Our results do not exclude a contribution from other reported genetic or epigenetic factors to CM cell-cycle arrest after birth (Muralidhar et al, 2013;Porrello and Olson, 2014;Takeuchi, 2014;Quaife-Ryan et al, 2016).…”
Section: Discussioncontrasting
confidence: 90%
See 1 more Smart Citation
“…Potential genomic imbalance caused by breakage of chromosome bridges in binucleated CMs could constitute a barrier to proliferation. Our results do not exclude a contribution from other reported genetic or epigenetic factors to CM cell-cycle arrest after birth (Muralidhar et al, 2013;Porrello and Olson, 2014;Takeuchi, 2014;Quaife-Ryan et al, 2016).…”
Section: Discussioncontrasting
confidence: 90%
“…Why lower vertebrates maintain proliferation capacity throughout life whereas mammals lose it soon after birth is largely unknown. Although regulators of CM cell-cycle arrest have been identified in recent years, the molecular mechanisms driving permanent cell-cycle arrest of CMs remain poorly understood (Muralidhar et al, 2013;Porrello and Olson, 2014;Takeuchi, 2014;Quaife-Ryan et al, 2016). Identifying these mechanisms is crucial for the development of new therapies for the treatment of myocardial infarction and heart failure.…”
Section: Introductionmentioning
confidence: 99%
“… 15 However, even with the most potent cardiac mitogens in these studies, cardiomyocyte proliferation rates fail to reach neonatal levels in the adult heart and are generally not sufficient to drive a full regenerative response. 16 As such, there is a fundamental need to define the core biological processes and mechanisms that govern cardiomyocyte proliferative capacity.…”
mentioning
confidence: 99%
“…By using pharmacologic and genetic methods, investigators determined that zinc-dependent HDACs are required for liver regeneration (Huang et al, 2013) and that overexpressing SIRT1 (a Class III HDAC) also suppressed hepatocyte proliferation by impairing farnesoid X receptor activity (Garcia-Rodriguez et al, 2014). Similarly, it has been thoroughly reviewed that epigenetic factors regulate the development and regeneration of pancreas (Avrahami et al, 2012; Migliorini et al, 2014), heart (Quaife-Ryan et al, 2016), and CNS (Arlotta et al, 2014; Petersen et al, 2016). …”
Section: Differences Between Hc Regeneration and Hc Developmentmentioning
confidence: 99%