Wuzi Yanzong Pill Plays A Neuroprotective Role in Parkinson’s Disease Mice via Regulating Unfolded Protein Response Mediated by Endoplasmic Reticulum Stress

Li, Yanrong; Fan, Huijie; Sun, Ruirui; Jia, Lu; Yang, Li-yang; Zhang, Hai-fei; Jin, Xiaoming; Xiao, Bao‐Guo; Ma, Cun‐Gen; Chai, Zhi

doi:10.1007/s11655-022-3727-0

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…WYP is a classic prescription of kidney tonifying in TCM and has been found to have positive effects on the prevention and treatment of central nervous system diseases (Hang et al, 2022; Li et al, 2023). Toxicological studies have shown that WYP is highly effective, with low toxicity and side effects, and high safety profile (Jin et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Wuzi Yanzong Pill protects neural tube defects by activating PI3K/Akt signaling pathway

Wang

Yang

et al. 2023

Intl J of Devlp Neuroscience

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Neural tube defects (NTDs) are severe congenital malformations that can lead to lifelong disability. Wuzi Yanzong Pill (WYP) is an herbal formula of traditional Chinese medicine (TCM) that has been shown to have a protective effect against NTDs in a rodent model induced by all‐trans retinoic acid (atRA), but the mechanism remains unclear. In this study, the neuroprotective effect and mechanism of WYP on NTDs were investigated in vivo using an atRA‐induced mouse model and in vitro using cell injury model induced by atRA in Chinese hamster ovary (CHO) cells and Chinese hamster dihydrofolate reductase‐deficient (CHO/dhFr) cells. Our findings suggest that WYP has an excellent preventive effect on atRA‐induced NTDs in mouse embryos, which may be related to the activation of the PI3K/Akt signaling pathway, improved embryonic antioxidant capacity, and anti‐apoptotic effects, and this effect is not dependent on folic acid (FA). Our results demonstrated that WYP significantly reduced the incidence of NTDs induced by atRA; increased the activity of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), and content of glutathione (GSH); decreased the apoptosis of neural tube cells; up‐regulated the expression of phosphatidylinositol 3 kinase (PI3K), phospho protein kinase B (p‐Akt), nuclear factor erythroid‐2 related factor (Nrf2), and b‐cell lymphoma‐2 (Bcl‐2); and down‐regulated the expression of bcl‐2‐associated X protein (Bax). Our in vitro studies suggested that the preventive effect of WYP on atRA‐treated NTDs was independent of FA, which might be attributed to the herbal ingredients of WYP. The results suggest that WYP had an excellent prevention effect on atRA‐induced NTDs mouse embryos, which may be independent of FA but related to the activation of the PI3K/Akt signaling pathway and improvement of embryonic antioxidant capacity and anti‐apoptosis.

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Section: Discussionmentioning

confidence: 99%

Wuzi Yanzong Pill protects neural tube defects by activating PI3K/Akt signaling pathway

Wang

Yang

et al. 2023

Intl J of Devlp Neuroscience

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“…In this context, intraperitoneal injection of MPTP has been used as a PD model. Following treatment with Wuzi Yanzong prescription, there was a reduction in GRP78 levels in the striatum and cortex, as well as decreased levels of p-PERK, p-eIF2α, ATF4, p-IRE1α, XBP1, and CHOP [214].…”

Section: Impact Of Natural Compounds On Er Stressmentioning

confidence: 99%

Modulating Stress Proteins in Response to Therapeutic Interventions for Parkinson’s Disease

Silvestro,

Raffaele,

Mazzon

2023

IJMS

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Parkinson’s disease (PD) is a neurodegenerative illness characterized by the degeneration of dopaminergic neurons in the substantia nigra, resulting in motor symptoms and without debilitating motors. A hallmark of this condition is the accumulation of misfolded proteins, a phenomenon that drives disease progression. In this regard, heat shock proteins (HSPs) play a central role in the cellular response to stress, shielding cells from damage induced by protein aggregates and oxidative stress. As a result, researchers have become increasingly interested in modulating these proteins through pharmacological and non-pharmacological therapeutic interventions. This review aims to provide an overview of the preclinical experiments performed over the last decade in this research field. Specifically, it focuses on preclinical studies that center on the modulation of stress proteins for the treatment potential of PD. The findings display promise in targeting HSPs to ameliorate PD outcomes. Despite the complexity of HSPs and their co-chaperones, proteins such as HSP70, HSP27, HSP90, and glucose-regulated protein-78 (GRP78) may be efficacious in slowing or preventing disease progression. Nevertheless, clinical validation is essential to confirm the safety and effectiveness of these preclinical approaches.

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“…WYP can work for decreasing the number of white blood cells in peripheral blood and promoting the production of antibodies in spleen cells [ 12 ]. Previous studies have shown that WYP has neuroprotective effects on Parkinson's disease and cuprizone-induced demyelination [ [13] , [14] , [15] ]. In the clinical observation of WYP in the treatment of Parkinson's disease, a Nervous system disease, we found that the symptoms of Parkinson's disease in patients taking WYP were significantly improved.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and mechanism of Wuzi Yanzong pill on the prevention and treatment of EAE

Li,

Zhang,

Sun

et al. 2023

Heliyon

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Wuzi Yanzong Pill Plays A Neuroprotective Role in Parkinson’s Disease Mice via Regulating Unfolded Protein Response Mediated by Endoplasmic Reticulum Stress

Cited by 6 publications

References 27 publications

Wuzi Yanzong Pill protects neural tube defects by activating PI3K/Akt signaling pathway

Wuzi Yanzong Pill protects neural tube defects by activating PI3K/Akt signaling pathway

Modulating Stress Proteins in Response to Therapeutic Interventions for Parkinson’s Disease

Efficacy and mechanism of Wuzi Yanzong pill on the prevention and treatment of EAE

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