WSZG inhibits BMSC-induced EMT and bone metastasis in breast cancer by regulating TGF-β1/Smads signaling

Ma, Jiao; Li, Jiajia; Wang, Ying; Chen, Weiling; Zheng, Peiyong; Chen, Yueqiang; Sun, Zhijing; Liu, Jin; Zhou, Yin; Wang, Jianyi; Liu, Sheng; Han, Xin

doi:10.1016/j.biopha.2019.109617

Cited by 15 publications

(6 citation statements)

References 60 publications

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“…135 The TGF-β1/Smads pathway was an important mechanism for bone marrow-derived MSCs to induce EMT in breast cancer cells. 136 The Wnt/β-catenin signaling pathway and Wnt activity are associated with ovarian cancer classification, EMT, chemotherapy resistance, and poor prognosis. In addition, the ERK protein subfamily made a huge contribution to EMT and was overexpressed and overactive in various types of cancers.…”

Section: Exosome and Cancer-associated Fibroblastsmentioning

confidence: 99%

Exosomes: key players in cancer and potential therapeutic strategy

Dai

Zhong

et al. 2020

Sig Transduct Target Ther

632

384

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Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long noncoding RNA, circular RNA, etc., which play a crucial role in regulating tumor growth, metastasis, and angiogenesis in the process of cancer development, and can be used as a prognostic marker and/or grading basis for tumor patients. Hereby, we mainly summarized as followed: the role of exosome contents in cancer, focusing on proteins and noncoding RNA; the interaction between exosomes and tumor microenvironment; the mechanisms that epithelial-mesenchymal transition, invasion and migration of tumor affected by exosomes; and tumor suppression strategies based on exosomes. Finally, the application potential of exosomes in clinical tumor diagnosis and therapy is prospected, which providing theoretical supports for using exosomes to serve precise tumor treatment in the clinic.

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Section: Exosome and Cancer-associated Fibroblastsmentioning

confidence: 99%

Exosomes: key players in cancer and potential therapeutic strategy

Dai

Zhong

et al. 2020

Sig Transduct Target Ther

632

384

View full text Add to dashboard Cite

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“…When these MSCs were co-cultured with a breast cancer cell model, there was a coincident reduction in EMT-associated genes (e.g., ZEB1/2, TWIST1, SNAIL, FOXC2, N-Cadherin (Fig 6E )). The role of TGFβ signaling in inducing EMT in cancer cells has been fairly well characterized [82][83][84][85]. Our results suggest that TGFβ signaling may be more important in driving pro-tumor effects from cancer-associated MSCs.…”

Section: Plos Onementioning

confidence: 53%

Identification of molecularly unique tumor-associated mesenchymal stromal cells in breast cancer patients

et al. 2023

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The tumor microenvironment is a complex mixture of cell types that bi-directionally interact and influence tumor initiation, progression, recurrence, and patient survival. Mesenchymal stromal cells (MSCs) of the tumor microenvironment engage in crosstalk with cancer cells to mediate epigenetic control of gene expression. We identified CD90+ MSCs residing in the tumor microenvironment of patients with invasive breast cancer that exhibit a unique gene expression signature. Single-cell transcriptional analysis of these MSCs in tumor-associated stroma identified a distinct subpopulation characterized by increased expression of genes functionally related to extracellular matrix signaling. Blocking the TGFβ pathway reveals that these cells directly contribute to cancer cell proliferation. Our findings provide novel insight into communication between breast cancer cells and MSCs that are consistent with an epithelial to mesenchymal transition and acquisition of competency for compromised control of proliferation, mobility, motility, and phenotype.

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“…Ma et al demonstrated that Wensheng Zhuanggu (WSZG) suppressed the motility and invasion in breast cancer cells by down-regulating TGF-β1/Smads signaling pathway. WSZG reversed the effects of bone marrow-derived mesenchymal stem cells (BMSC) that enhanced the bone-invasive and metastatic tendency of breast cancer cells by inducing EMT, implying the potential application as an anti-bone metastatic agent [ 128 ]. Wang et al validated the critical role of CXCL1 in mediating anti-metastatic activities of Xiaopi formula such as inhibiting stem cells subpopulation, and suppressing metastatic micro-environment formation.…”

Section: Resultsmentioning

confidence: 99%

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

et al. 2021

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Metastasis is the main cause of cancer-related death. Despite its high fatality, a comprehensive study that covers anti-metastasis of herbal medicines has not yet been conducted. The aim of this study is to investigate and assess the anti-metastatic efficacies of herbal medicines in the five major cancers, including lung, colorectal, gastric, liver, and breast cancers. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with “cancer metastasis” and “herbal medicine” as keywords. Correspondingly, 16 lung cancer, 23 colorectal cancer, 10 gastric cancer, 10 liver cancer, and 18 breast cancer studies were systematically reviewed. The herbal medicines attenuated metastatic potential targeting various mechanisms such as epithelial mesenchymal transition (EMT), reactive oxygen species (ROS), and angiogenesis. Specifically, the drugs regulated metastasis related factors such as matrix metalloproteinase (MMP), serine-threonine protein kinase/extracellular regulated protein kinase (AKT/ERK), angiogenic factors, and chemokines. Overall, the present study is the first review, comprehensively investigating the anti-metastasis effect of herbal medicines on five major cancers, providing the experimental models, doses and durations, and mechanisms. Herbal medicines could be a potent candidate for anti-metastatic drugs.

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WSZG inhibits BMSC-induced EMT and bone metastasis in breast cancer by regulating TGF-β1/Smads signaling

Cited by 15 publications

References 60 publications

Exosomes: key players in cancer and potential therapeutic strategy

Exosomes: key players in cancer and potential therapeutic strategy

Identification of molecularly unique tumor-associated mesenchymal stromal cells in breast cancer patients

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

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