Wound Repair and Experimental Wound Models

Baktir, G.

doi:10.26650/experimed.2019.19023

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…We utilized the excision wound model improved by Morton and Malone (14). The excision wound was made on the dorsal part of the mice 1 cm away from the spine and 5 cm from the ears under anesthesia with a combination of ketamine and xylazine (20/10 mg/kg).…”

Section: Excision Wound Modelmentioning

confidence: 99%

“…Many studies have revealed that TRP has many biological and pharmacological activities, including antimicrobial, anti-inflammatory, anti-allergic, anti-cancer, anti-protozoal, and anti-allergic effects ( 8 - 13 ). The excisional wound (EW) model utilized in the present research is the most used wound model, and it is easy to register the time-dependent closure rate of the wound by forming an open wound ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

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A Lead Target Molecule for Excisional Wound Healing: Trypthantrin Compound

Kutlu¹,

Halıcı

Gedikli

et al. 2022

Iran J Pharm Res

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Objectives: We aimed to evaluate the impact of the tryptanthrin (TRP) compound, with antimicrobial and anti-inflammatory effects, on the excisional wound (EW) model. In an EW model in mice, we tried to explain the possible effect of TRP through vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) that contribute significantly to wound healing. Methods: A total of 90 BALB-C female mice aged 6 - 8 weeks were used in the present study. Animals were randomly divided into five groups. After creating the EW model, three different doses (1, 2.5, 5 mg/kg) of TRP compound were applied topically for 14 days, and wound closure rates were measured on days 0, 3, and 7. Vascular endothelial growth factor and MMP-9 were evaluated on days 3, 7, and 14 on wound explants and on day 14 on serum samples by enzyme-linked immunosorbent assay. Histopathological analysis was performed on wound explants. Results: After the EW model creation, significant healing of the wound areas was observed in the groups for which TRP was applied, especially on the third day. Moreover, in groups that received the third dose of TRP, the wound closure rate was 94%. It was found that the wound areas were closed due to the increase in TRP dose. In line with wound healing, VEGF and MMP-9 levels gradually rose on the third and seventh days and decreased on the 14th day. Conclusions: Tryptanthrin compound usage on the EW model increased wound healing and did not leave a scar after 14 days.

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Section: Excision Wound Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Lead Target Molecule for Excisional Wound Healing: Trypthantrin Compound

Kutlu¹,

Halıcı

Gedikli

et al. 2022

Iran J Pharm Res

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“…Wounds disrupt the integrity of the skin or mucosa by various internal or external factors [ 1 ]. Wound healing is a complex and dynamic processes in the human body; it replaces devitalized and missing cellular structures and tissue layers.…”

Section: Introductionmentioning

confidence: 99%

Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes

et al. 2022

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Complications of chronic non-healing wounds led to the emergence of nanotechnology-based therapies to enhance healing, facilitate tissue repair, and prevent wound-related complications like infections. Here, we design alpha lipoic acid (ALA) conjugated hexagonal boron nitride (hBN) and boron carbide (B4C) nanoparticles (NPs) to enhance wound healing in human dermal fibroblast (HDFa) cell culture and characterize its antimicrobial properties against Staphylococcus aureus (S. aureus, gram positive) and Escherichia coli (E. coli, gram negative) bacterial strains. ALA molecules are integrated onto hBN and C4B NPs through esterification procedure, and molecular characterizations are performed by using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and UV-vis spectroscopy. Wound healing and antimicrobial properties are investigated via the use of cell viability assays, scratch test, oxidative stress, and antimicrobial activity assays. Based on our analysis, we observe that ALA-conjugated hBN NPs have the highest wound-healing feature and antimicrobial activity compared to ALA-B4C. On the other hand, hBN, ALA-B4C, and ALA compounds showed promising regenerative and antimicrobial properties. Also, we find that ALA conjugation enhances wound healing and antimicrobial potency of hBN and B4C NPs. We conclude that the ALA-hBN conjugate is a potential candidate to stimulate regeneration process for injuries.

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Characterization of gelatin-based wound dressing biomaterials containing increasing coconut oil concentrations

Karamanlioglu,

Yesilkir-Baydar

2023

Journal of Biomaterials Science, Polymer Edition

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Wound Repair and Experimental Wound Models

Cited by 6 publications

References 37 publications

A Lead Target Molecule for Excisional Wound Healing: Trypthantrin Compound

A Lead Target Molecule for Excisional Wound Healing: Trypthantrin Compound

Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes

Characterization of gelatin-based wound dressing biomaterials containing increasing coconut oil concentrations

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