Wound healing strategies based on nanoparticles incorporated in hydrogel wound patches

Abstract

Nanoparticle-modified hydrogels exhibit substantial promise in the realm of wound healing, with their ability to expedite tissue regeneration, mitigate infection risks, and facilitate enhanced therapeutic outcomes.

Bletilla striata Polysaccharide-/Chitosan-Based Self-Healing Hydrogel with Enhanced Photothermal Effect for Rapid Healing of Diabetic Infected Wounds via the Regulation of Microenvironment

“…The increase in the number of M1 macrophages and neutrophils in chronic wound sites is closely related to the elevated levels of ROS, chemokines, and cytokines, and these factors mutually promote the inflammation, forming a constant vicious cycle and hindering wound healing. Combined with the abilities to regulate the microenvironment of the wound, including the regulation of the inflammatory cytokine levels, reduction of ROS, and promotion of cell migration, the hydrogel was expected to possess good capability that promotes the healing of chronic wounds.…”

“…14 It has been reported that the control of ROS level could alleviate the oxidative damage at the wound site, promote the proliferation of epithelial cells, angiogenesis, and tissue restoration; therefore, the antioxidant activity of CuO@BER/BH hydrogel was beneficial to the wound healing. 63 The increase in the number of M1 macrophages and neutrophils in chronic wound sites is closely related to the elevated levels of ROS, chemokines, and cytokines, and these factors mutually promote the inflammation, forming a constant vicious cycle 64 and hindering wound healing. Combined with the abilities to regulate the microenvironment of the wound, including the regulation of the inflammatory cytokine levels, reduction of ROS, and promotion of cell migration, the hydrogel was expected to possess good capability that promotes the healing of chronic wounds.…”

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

“…Hydrogels also offer controlled release ability, enabling gradual and targeted delivery of NZs, which is particularly advantageous in chronic skin defects [ 70 , 71 ]. For instance, Li et al utilized selenide-bound polydopamine-reinforced composite hydrogels (DSeP@PB) with on-demand degradation and light-activated NZ release properties for regenerating diabetic skin wounds [ 42 ].…”

Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends

“…In addition to the promising results of the experimental studies on the nanoparticle-hydrogel systems, the commercial availability of nanoparticlecontaining antimicrobial dermal patches for wound healing are encouraging examples for the clinical translation of the antimicrobial nanoparticle-hydrogel systems. 263 However, despite signicant progress and promising results at the laboratory scale the clinical translation of these nanoparticlehydrogel systems for delivery of the antimicrobial agents is a challenging task. Currently, no antimicrobial nanoparticlehydrogel system is commercially available and only some such systems have entered clinical trials (mainly for local applications) such as silver nanoparticles containing xanthan gum hydrogel (NCT01442103), Silver nanoparticle gels for pain associated with a postoperative root canal (NCT03692286), Gold-silver-Cu 2 O nano gel with photothermal therapy (PTT) form antibiotic-resistant eye keratitis (NCT05268718), and PLGA nanoparticles coated with chitosan encapsulating cipro-oxacin incorporated into temperature-sensitive pluronic hydrogel treatment of endodontic infections (NCT05442736) (https://clinicaltrials.gov).…”

“…that should be ne-tuned to overcome these challenges. 263,264,266 In addition, when the hydrogels and nanoparticles are combined as nanoparticlehydrogel systems their safety evaluation and clinical translation becomes even more complex. 264 To overcome these challenges of translation of these systems to clinics, the researchers should investigate in-depth the in vivo interaction of the system, their toxicity (acute and chronic), and the ultimate fate inside the body using a variety of advanced techniques.…”