Wound healing/regeneration using recombinant human growth/differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs

Abstract

rhGDF-5 appears to effectively support periodontal wound healing/regeneration in a dose-dependent order; the PLGA composite appears to be an effective ease-of-use candidate for carrier technology.

Maturation of alveolar bone following implantation of an rhGDF‐5/PLGA composite into 1‐wall intra‐bony defects in dogs: 24‐week histometric observations

“…In a previous study, the rhGDF‐5/PLGA construct significantly increased bone and cementum formation in a dose‐dependent order in absence of root resorption/ankylosis, the newly formed bone mainly composed of hypercellular woven bone over an 8‐week healing interval (Min et al. ). Also, the rhGDF‐5/PLGA construct appeared to maintain its initial volume.…”

“…, , Min et al. ). The injectable ease‐of‐use PLGA composite features structural integrity upon setting in situ, space providing micro/macro‐porosity, bioadhesion for clot stabilization and biodegradation for rapid clearance (Herberg et al.…”

“…Our previous study evaluating rhGDF‐5/PLGA using the surgically created 1‐wall intra‐bony defect model and an 8‐week healing interval showed a dose dependent increase in cementum and alveolar bone formation (Min et al. ). The total area of newly formed alveolar bone was significantly greater in the rhGDF‐5 high dose group, however, it remain unclear whether maturation of the newly formed periodontal tissues would maintain integrity or morph into ankylosis/root resorption as shown for rhBMP‐2 (Wikesjö et al.…”

Future Prospects for Periodontal Bioengineering Using Growth Factors

“…26 More recently, the BMP/transforming growth factor-β family member known to have a role in skeletal and joint development, growth and differentiation factor-5 (GDF-5), has demonstrated significant potential in the regeneration of periodontal ligament (PDL) and bone in vertical bone defects using PLGA and β-tricalcium phosphate carriers. 27–29 Advances in computer-aided design–computer-aided manufacturer technology over the years coupled with the expanded use of cone beam computed tomography for imaging three-dimensional structures allows for the construction of anatomically corrected scaffolds for intimate, highly accurate fitting to complex topographies of bone 30–32 and periodontal defects (Fig. 2).…”

Detection and characterization of interleukin-6 gene variants in Canis familiaris: Association studies with periodontal disease

“…Despite the long history of use of this animal model in the periodontology research, it remains a very actual model, especially in studies involving the development of new methodologies or therapeutic protocols (e.g. Polimeni et al, 2009;Min et al, 2011). The results of these studies allow a reflection on the usefulness of dogs in other research lines, such as the genetic factors associated to PD susceptibility.…”