Maturation of alveolar bone following implantation of an rhGDF‐5/PLGA composite into 1‐wall intra‐bony defects in dogs: 24‐week histometric observations

Abstract

The rhGDF-5/PLGA appears to support alveolar bone healing/regeneration and the rhGDF-5/PLGA high dose uniquely increased maturation of the regenerated bone.

TiO2scaffolds in peri‐implant dehiscence defects: an experimental pilot study

“…These materials may be customized with respect to porosity, interconnectivity, compressive strength, and degradation. Some previously tested synthetic graft materials for bone regeneration are biphasic calcium phosphate (Cordaro et al 2008;Frenken et al 2010), porous titanium (Delgado-Ruiz et al 2014;Lyngstadaas et al 2015), hydroxyapatite (Crespi et al 2012), tricalcium phosphate (Horowitz et al 2009;Shalash et al 2013) and polymers (Bertoldi et al 2008;Park et al 2012).…”

Biological agents and cell therapies in periodontal regeneration

“…When absorbable collagen sponge was compared to β‐TCP, the latter carrier induced significantly more bone formation, probably due to slower release of the growth factor . The positive effect of GDF‐5 on alveolar bone appears to continue long‐term .…”

Description of the periodontal pocket in preclinical models: limitations and considerations

“…Currently, numerous species, including nonhuman primates, dogs, rodents, sheep, miniature pigs, rabbits, hamsters, ferrets and other animals, have been used to evaluate the pathogenesis and treatment of periodontitis . However, there is no simple and reproducible animal model that adequately replicates the pathogenesis of periodontal disease in the way it occurs in humans; furthermore, the models described are not always free from bias and consequently this interferes with the interpretation of the results .…”

“…However, placing a notch at the alveolar bone crest level to mark the apical limit of instrumentation may result in overestimation of the pathological process . The stimulating effect of the notch itself to induce cementum formation has also been discussed . It has been reported that intrabony defects of one, two and three walls often display spontaneous bone healing, and surgical defects treated without any regenerative modality sometimes demonstrate a certain amount of bone regeneration at the base of the defect .…”

“…Moreover, the advantages and disadvantages of these models, in terms of standardization, reproducibility and similarity to high incidence human conditions, will be discussed. periodontitis (71,82,106,119,131,141). However, there is no simple and reproducible animal model that adequately replicates the pathogenesis of periodontal disease in the way it occurs in humans; furthermore, the models described are not always free from bias and consequently this interferes with the interpretation of the results (51).…”