Wound healing of degree III furcation involvements following guided tissue regeneration and/or Emdogain^®

Abstract

The results provided histological evidence suggesting that both GTR and EMD may result in true periodontal regeneration, and suggest that this type of healing might be favored by such treatments in comparison with flap surgery.

Differential Effect of Amelogenin Peptides on Osteogenic DifferentiationIn Vitro: Identification of Possible New Drugs for Bone Repair and Regeneration

“…1 They are the main constituents of enamel matrix protein (EMP), a complex mixture of components secreted during root formation, and have been extensively studied partly because of their effect on osteogenic differentiation in vitro and bone regeneration in vivo. [2][3][4][5][6][7][8] Thus, EMP has been reported to promote osteogenesis by upregulating bone-associated genes such as alkaline phosphatase (ALP), osteopontin (OP), osteocalcin (OC), and bone sialoprotein (BSP), and by stimulating the production of bone-like mineralized nodules in vitro. 2,5 However, other studies have shown that EMP downregulated these bone-associated markers and terminal osteogenic differentiation of human periodontal ligament (PDL) cells, osteoblasts, and bone marrow-derived mesenchymal stem cells (BMSC).…”

Pre-clinical Models for Oral and Periodontal Reconstructive Therapies

“…Collagen fibers appear disorganized in the coronal areas, while in the apical regions collagen fibers anchor in the newly formed cementum (Sander and Karring, 1995). Periodontal regeneration progresses until about 5 mos, when new bone with a mature periodontium is found (Karatzas et al, 1999;Sculean et al, 2000b;Donos et al, 2003;Zhang et al, 2004). Chronic periodontal defects do not regenerate spontaneously, allowing for a greater observation window for the regenerative response to NMF.…”

“…Moreover, chronic defects closely resemble those in the human situation, with respect to the microbial flora and the inflammatory reaction (Caton et al, 1994;Karatzas et al, 1999). Surgically created periodontal defects have been used to study the impact of GTR or GBR and the application of biologics, including enamel matrix proteins, BMP-2, FGF-2, TGF-β3, and PDGF (Sculean et al, 1997(Sculean et al, , 2000bRipamonti et al, 2001;Takayama et al, 2001;Donos et al, 2003;Teare et al, 2008). Potential endpoint analyses are generally performed between 3 and 6 mos by measurement of the length and/or area of new attachment, cementum, and bone.…”

Periodontal regeneration in intrabony defects after application of enamel matrix proteins with guided tissue regeneration: An experimental study in dogs

“…Recent studies have demonstrated that enamel matrix protein (EMP) induces the formation of cellular cementum in defects surrounded by dentin and alveolar bone in monkeys and in the minipigs (8,9). Proliferation, protein production and calcifi cation of periodontal ligament cells have been shown in vitro, fourth teeth.…”