Wound Healing of Animal and Human Body Sport and Traffic Accident Injuries Using Low-Level Laser Therapy Treatment: A Randomized Clinical Study of Seventy-Four Patients with Control Group

Simunovic, Zlatko; Ivankovich, Anthony D.; Depolo, Arsen

doi:10.1089/clm.2000.18.67

Cited by 71 publications

(56 citation statements)

References 4 publications

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“…Such data corroborate the results from other authors who have used LILT during 12 days of tissue repair processes and verified responses from the fibroblastic cells and collagen molecules to the treatment 7,8,[19][20][21][22][23][24][25][26][27][28] . The types of activation ways proposed for the laser, take into account its action over the chromophores situated at the mitochondrias and cell membranes.…”

Section: Discussionsupporting

confidence: 90%

Influência de diferentes comprimentos de onda da laserterapia de baixa intensidade na regeneração tendínea do rato após tenotomia

Erb

Rodrigues

Taciro

et al. 2007

Rev. bras. fisioter.

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Objective: The aim of this study was to compare the effect of the low level laser therapy in the organization of the collagen fibers with 3 J/cm² of dose in two wavelengths (670nm and 904nm) and in the combination of both on the tissue repair of the calcaneus tendon. Methods: We used 37 female Wistar rats divided in 5 groups which had been submitted to the total tenotomy. Group GA (n= 8) was submitted to the laser irradiation in λ= 904nm, GaAS, pulsated emission, peak power 15W and dose of 3J/ cm², group GB (n= 8) was submitted to laser irradiation λ= 670nm AlGaInP diode, continuous emission, power 30 mW and dose 3J/cm², group GAB (n= 8) was submitted to association of both of lasers and group GCL (n= 7) which the calcaneum tendon was submitted to placebo treatment. The group GP (n= 6) was a standard group without lesion and treatment. The animals received 12 sessions of lasertherapy and submitted to euthanasia on 14 th day after surgery. The tendons were submitted to histological procedure and were analyzed to evaluate the optic retardation (in nm) for the birefringence measurement. Results: The statistic analysis showed that the irradiated groups have higher values of optic retardation statistically significant than placebo group (p= 0,00001). It indicates that all the treated groups show better organization of collagen fibers in the longitudinal axis of the tendon, evidencing better quality in the tissue repair. The group GAB was that shown best results (p= 0,00001) when compared to another groups.

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Section: Discussionsupporting

confidence: 90%

Influência de diferentes comprimentos de onda da laserterapia de baixa intensidade na regeneração tendínea do rato após tenotomia

Erb

Rodrigues

Taciro

et al. 2007

Rev. bras. fisioter.

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“…However, previous work has shown that both pain relief and enhanced wound healing can be initiated using direct and indirect LLLT effects on cellular activity. Direct cellular activation is postulated to lead to indirect activation of distant cells via secondary messengers (reactive oxygen species, lymphokines, cytokines, nitric oxide, and calcium) released by directly activated cells [12,34,35] . In this study, it was not possible to ascertain whether treatment of the nerves proximal to the wound site enhanced wound healing or alleviated potential discomfort at the wound site.…”

Section: Discussionmentioning

confidence: 99%

Equine wound healing: influence of low level laser therapy on an equine metacarpal wound healing model

Jann

Bartels

Ritchey³

et al. 2012

Photonics &Amp; Lasers in Medicine

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Objective: To evaluate the effects of low level laser therapy (LLLT) on healing of full thickness symmetrical skin wounds in horses. LLLT is a therapeutic modality using the application of light, usually a low power laser or light emitting diode in the power range of 1 mW to 12 W that, in practical terms, promotes tissue regeneration as well as reducing infl ammation and pain. Study design: Experimental study. Animals: Healthy horses (n = 8). Methods: Full thickness, 2.5 cm square skin wounds were created in the mid-metacarpal region on one leg of eight normal horses. LLLT was used on limbs assigned to the experimental group and limbs assigned to the control group were allowed to heal without treatment. LLLT was administered using a line generated optical scanner with a dual diode laser system (model EML; Erchonia Laser Healthcare, McKinney, TX, USA) at a wavelength of 635 nm and an energy output of 17 mW per diode. Wound size was measured for an 80-day period post operatively. Eighty days after surgery incisional biopsies were examined histologically. Results: Wounds treated with LLLT healed faster than the control wounds ( p = 0.01). Wounds treated with LLLT were completely epithelialized at day 80 after surgery. Control wounds were not epithelialized at postoperative day 80. Conclusion: LLLT increased the rate of wound healing. Schl ü sselw ö rter: Wunden; Wundheilung; Mittelfu ß bereich; Low-Level-Laser-Therapie (LLLT); Epithelisierung. Keywords

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“…Some authors have demonstrated that lowlevel laser therapy (LLLT) stimulates wound healing, by increasing collagen deposition and blood flow in the wound area. [6][7][8][9][10][11][12][13] Some lasers, when used with the proper parameters, affect fibroblasts and collagen production in vitro, and promising results have been found utilizing the HeNe laser (632.8 nm) with multiple exposures. 9,[14][15][16][17][18][19] One effect of laser therapy (5 J/cm 2 ) is increased local blood flow in normal human skin of the sole of the foot.…”

Section: Introduction Dmentioning

confidence: 99%

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

Rabêlo

Villaverde

Nicolau

et al. 2006

Photomedicine and Laser Surgery

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Objective: The aim of this work was to compare the effect of low-level laser therapy (LLLT) on the wound healing process in nondiabetic and diabetic rats. Background Data: Among the clinical symptoms caused by diabetes mellitus, a delay in wound healing is a potential risk for patients. It is suggested that LLLT can improve wound healing. Methods: The tissue used for this study was extracted from animals suffering from diabetes, which was induced by Streptozotocin ® , and from nondiabetic rats. Animals were assembled into two groups of 25 rats each (treated and control) and further subdivided into two groups: diabetic (n = 15) and nondiabetic (n = 10). A full-thickness skin wound was made on the dorsum area, with a round 8-mm holepunch. The treated group was irradiated by a HeNe laser at 632.8 nm, with the following parameters: 15 mW, exposition time of 17 sec, 0.025 cm 2 irradiated area, and energy density of 10 J/cm 2 . Square full-thickness skin samples (18 mm each side, including both injured and noninjured tissues) were obtained at 4, 7, and 15 days after surgery and analyzed by qualitative and quantitative histological methods. Results: Quantitative histopathological analysis confirmed the results of the qualitative analysis through histological microscope slides. When comparing tissue components (inflammatory cells, vessels and fibroblast/area), we found that treated animals had a less intense inflammatory process than controls. Conclusion: Results obtained by both qualitative and quantitative analyses suggested that irradiation of rats with HeNe (632.8 nm), at the tested dose, promoted efficient wound healing in both nondiabetic and diabetic rats as, compared to the control group. 474

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Wound Healing of Animal and Human Body Sport and Traffic Accident Injuries Using Low-Level Laser Therapy Treatment: A Randomized Clinical Study of Seventy-Four Patients with Control Group

Cited by 71 publications

References 4 publications

Influência de diferentes comprimentos de onda da laserterapia de baixa intensidade na regeneração tendínea do rato após tenotomia

Influência de diferentes comprimentos de onda da laserterapia de baixa intensidade na regeneração tendínea do rato após tenotomia

Equine wound healing: influence of low level laser therapy on an equine metacarpal wound healing model

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

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