Wound Healing Mechanisms

Flynn, Margaret; Rovee, David T.

doi:10.2307/3470332

Cited by 6 publications

(10 citation statements)

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“…Although previous work has shown that cervical regeneration is almost complete 6 months after excisional treatment22, our findings suggests that cellular function remains elevated at this time point. The presence of scar tissue at the site of injury may account for the increased polypeptides, since collagen is composed of three separate polypeptide chains23, and production is increased 2–3 times more in fibroblasts isolated from scar tissue than from normal tissue24. Despite this, a healed wound will only achieve a maximum of 80% of the tensile strength of normal epithelium.…”

Section: Discussionmentioning

confidence: 99%

Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy

Halliwell

Kyrgiou

Mitra

et al. 2016

Sci Rep

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Local excisional treatment for cervical intra-epithelial neoplasia (CIN) is linked to significant adverse sequelae including preterm birth, with cone depth and radicality of treatment correlating to the frequency and severity of adverse events. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy can detect underlying cervical disease more accurately than conventional cytology. The chemical profile of cells pre- and post-treatment may differ as a result of altered biochemical processes due to excision, or treatment of the disease. Since pre-treatment cervical length varies amongst women, the percentage of cervix excised may correlate more accurately to risk than absolute dimensions. We show that treatment for CIN significantly alters the biochemistry of the cervix, compared with women who have not had treatment; this is due to the removal of cervical tissue rather than the removal of the disease. However, the spectra do not seem to correlate to the cone depth or proportion of cervical length excised. Future research should aim to explore the impact of treatment in a larger cohort.

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Section: Discussionmentioning

confidence: 99%

Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy

Halliwell

Kyrgiou

Mitra

et al. 2016

Sci Rep

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“…This is the time period when the inflammatory response is crucial to the healing process. There is evidence that the administration of vitamin A during the initial postoperative period is effective in promoting an otherwise impaired inflammatory response (Ehrlich & Hunt, 1968;Flynn & Rovee, 1982). Nonsteroidal anti-inflammatory agents, especially aspirin, inhibit platelet aggregation and thus may predispose the client to capillary oozing which impedes healing.…”

Section: *mentioning

confidence: 99%

Assisting Elders to Care for Wounds

Arnp

Rnc

1990

Home Health Care Services Quarterly

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According to a survey of Medicare-certified home care agencies in the Northwest region, wound care was ranked as one of the top nine home care clinical problems. Earlier discharges precipitated by Diagnostic Related Groupings method of reimbursement meant that clients were sent home with newer, more complex and more difficult-to-care-for wounds. In addition, wound care technology has changed dramatically over the past ten years.This paper was designed to give home health nurses a thorough understanding of wound care. Psychosocial and physiological responses to wounds are reviewed including an analysis of factors that influence the healing process. The process of assessing and treating wounds is discussed along with methods and substances for cleansing and debriding and types of dressings with indications for their use.Those wounds reported to be especially problematic to.home care nurses are discussed: chronic skin ulcers, surgical wounds, and complex, draining wounds and fistulas.Multiple tables are presented to make it easier for the clinician to access needed information quickly.

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“…Examples of these are emollient topical circulatory stimulants (such as Granulex® and Proderm® sprays); transparent, semipermeable films (such as Bioclusive® or Opsite®); hydrocolloid and hydrogel dressings (such as Duoderm®, Ulcer Dressing®, or Vigilon®); exudate absorb ers (such as Debrisan® or Duoderm Gran ules®); continuous moist gauze dressings; and wound drainage collectors (Felice, 1985;Preston, 1987). Selection of a dress ing treatment is based on the short-term goals for the wound and the actions of the dressing in supporting normal healing mechanisms (Flynn & Rovee, 1982;Her bert & Alterescu, 1982). These dressing choices support the healing mechanisms of debridement and granulation, processes that could not take place in Mr. G.'s case.…”

Section: The Goalmentioning

confidence: 99%

Complex Wound Management: A Case Study

Preston¹,

Griffin²

1989

Rehabilitation Nursing

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Mr. G.'s situation was challenging, because it did not readily conform to the management techniques currently available and required consideration of psychosocial and other physical factors. To meet individual patient needs, nurses must be creative in finding solutions to unusual problems. By focusing on the short-term goals for wound management and the goals for family-centered home care as a guide to interventions, adaptations were made to fit this patient's needs.

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Wound Healing Mechanisms

Cited by 6 publications

References 0 publications

Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy

Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy

Assisting Elders to Care for Wounds

Complex Wound Management: A Case Study

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