Wound healing in the 21st century

Schreml, Stephan; Szeimies, Rolf‐Markus; Prantl, Lukas; Landthaler, Míchael; Babilas, Philipp

doi:10.1016/j.jaad.2009.10.048

Cited by 323 publications

(263 citation statements)

References 104 publications

Supporting

Mentioning

230

Contrasting

Unclassified

Order By: Relevance

“…Additionally, our results might help to explain the non-responsiveness to shock wave treatment in some patients suffering wound healing disorders. Besides well known factors contributing to wound healing such as age and lifestyle, the Erk1/2 signaling pathway has been described as crucial in the wound healing process (61,62). We therefore hypothesize that the non-responding patients might have an impaired Erk1/2 signaling pathway resistant to shock wave treatment.…”

Section: Discussionmentioning

confidence: 97%

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Weihs

Fuchs

Teuschl

et al. 2014

Journal of Biological Chemistry

140

124

View full text Add to dashboard Cite

Background: Signaling pathways underlying beneficial effects of extracorporeal shock wave treatment (ESWT) remain to be completely elucidated. Results: ESWT enhances cell proliferation in vitro and wound healing in vivo. Conclusion: ESWT-induced ATP release and subsequent extracellular signal-regulated kinase (ERK) activation are prerequisites for enhanced cell proliferation and wound healing. Significance: Deciphering the involved signaling cascades provides the basis for ESWT as clinical wound healing treatment.

show abstract

Section: Discussionmentioning

confidence: 97%

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Weihs

Fuchs

Teuschl

et al. 2014

Journal of Biological Chemistry

140

124

View full text Add to dashboard Cite

show abstract

“…That is, it is made up of three distinct timedependent phases: Inflammation, proliferation and remodeling (Schreml et al, 2010). How long each phase lasts depends on the severity of the insult that was the initiating factor.…”

Section: Discussionmentioning

confidence: 99%

Adaptation to High Grain Diets Proceeds Through Minimal Immune System Stimulation and Differences in Extracellular Matrix Protein Expression in A Model of Subacute Ruminal Acidosis in Non-lactating Dairy Cows

Idawaty¹

2012

American Journal of Animal and Veterinary Sciences

View full text Add to dashboard Cite

Problem statement: Subacute Ruminal Acidosis (SARA) is a metabolic disorder affecting approximately 20% of all dairy cattle in North America. Although the presence of SARA has been described for some time, the etiology of the disorder remains uncertain. For example, many animals diagnosed with SARA seem to remodel and adapt their epithelium to accommodate the stresses imposed by SARA, but not before exacting a significant health and economic toll. Specifically, a search is on in which a desire to identify the system and associated pathways that are causative agents in the progression and development of SARA is evident. We hypothesize that adaptation to SARA is facilitated by the immune system. Approach: In order to answer of this question, 4 mature, nonlactating dairy cattle were transitioned from a High Fiber (HF; 0% grain) diet to High Grain (HG; 65% grain) diet. Having fed the HG diet for three weeks, the cattle were then transitioned back to the HF diet for an additional three weeks to facilitate adaptation. SARA was diagnosed by pH data only during the first week and not during the remaining weeks, indicating that adaptation to the HG diet took place within one week. Results: In this study, significant (p<0.05) extracellular matrix protein changes (COL4A1, LAMB1) were seen during this study indicating a change in matrix architecture to facilitate adaptation. In addition, similar significant (p<0.05) patterns of expression of inflammatory cytokines and mediators of the LPS-mediated toll-like receptor pathway were seen. Conclusion: These results indicate that the immune system is involved in the adaptation of the rumen epithelium to a HG diet, but to a lesser extent than was previously thought. This is the first time an attempt has been made to link the immune system and wound healing in the adaptation of the bovine rumen to a HG diet.

show abstract

“…In addition, the collagen fi brils present in this matrix are strongly glycosylated, thin and show a parallel and not intermingled orientation 1,12,19 . After one week, the strength of the extracellular matrix is 3% of that of intact tissue.…”

Section: Histomorphometrymentioning

confidence: 98%

“…Despite a multidisciplinary approach, the management of patients with chronic wounds is a major challenge 1 . In addition to their profound effect on the quality of life of affected individuals, about 2% of the health budget is destined to wound care [2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Brassica oleracea in rats skin wound healing

et al. 2013

View full text Add to dashboard Cite

PURPOSE:To investigate the effect of Brassica oleracea herbal balsam on the healing of skin wounds in rats. METHODS:Twenty four rats (Wistar, 60 days, 250 g) were divided into four groups: untreated animals (C) and treated with the ointment (T), subdivided into two experimental times (seven and 16 days). A 3cm 2 skin wound was made in the back of all animals.100 ml of the Brassica oleracea was applied twice a day in T group. Biometric analysis was made with images captured at one, four, seven, ten, 13, and 16 days. At seven and 16 days, animals of each group were euthanized. The wound area removed was processed for histological and histomorphometric analysis to quantify birefringent collagen fibers. Statistical analysis was made considering p < 0.05 as significant. RESULTS:Biometric analysis revealed no significant differences between groups in both experimental times studied. However, histomorphometric analysis showed that the number of type I collagen fibers was significantly higher in the specimens of the group T16 compared to the other groups. CONCLUSION:Brassica oleracea accelerated the wound healing process increasing the number of type I collagen fibers and the maturity of the newly formed tissue.

show abstract

Wound healing in the 21st century

Cited by 323 publications

References 104 publications

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Adaptation to High Grain Diets Proceeds Through Minimal Immune System Stimulation and Differences in Extracellular Matrix Protein Expression in A Model of Subacute Ruminal Acidosis in Non-lactating Dairy Cows

Effect of Brassica oleracea in rats skin wound healing

Contact Info

Product

Resources

About