Wound Healing Effects of Edible Bird’s Nests Oinment (Aerodramus fuciphagus) in Alloxan-Induced Male Rats

Abstract

Edible bird's nest (Aedrodramus fuchipagus) contains EGF (Epidermal Growth Factor) and sialic acid which is useful in wound healing. The aim of this study was to investigate the effect of edible bird's nest on the injured Alloxan-induced rats to form optimal ointment formulation of edible bird's nest (Aedrodramus fuchipagus) which can heal wounds. The method used in this research is experimental using 25 Sprague Dawley rats divided into 5 groups in which each group consists of 5 rats; Group I was the control group (Vaseline + Betadine®), Group II, III, and IV were the group of EBN + Betadine® with concentrations of 10%, 20%, and 30%; and Group V was of the Sanoskin Meladerm® (SM) + Betadine® group. The rats were modeled for diabetes by inducing Alloxan (150mg/kgBW/i.p) and exposed with DM when the blood sugar level was > 200 mg/dL. The back skins were sliced as long as 2 cm and 2 mm depth and were given treatment according to the group, 1 x daily for 10 days. Parameters that were noticed were length wound, length of the dry wound, and the number of days of scab formation. The results obtained in the control group were 10%, 20%, and 30% on the EBN group, and the SM group on the 9th day were 1.3±0.2449, 0.34±0.427, 0.56±0.4586, 0±0, 0±0. The results of the average length of the dry wound in the control group were 10%, 20%, and 30% on the EBN group, and the SM group were 1±0.5, 2±1.5, 4±0, 8, 1±0.8, and 2±0.63. While the result of the average day of scab formation on the control group was 10%, 20%, and 30% on the EBN groups, SM Groups were 1.3±0.47, 2.2±1.6, 3.8±0.8, 1±0, and 2±0.63. Based on Kruskal Wallis test, there were significant differences in the wound length among treatment groups (sig 0.013) and significant differences in dry wounds among treatment groups (sig 0.046), but there was no difference in the time of scab formation among treatment groups (sig 0.066). In conclusion, edible bird’s nest (Aedrodramus fuchipagus) ointment concentration of 30% is the most optimal ointment to wound healing in Alloxan-induced male rats when compared to Sanoskin Melladerm.

Skin Histopathology of Diabetes Mellitus Rats Treated with Edible Nest Swiftlets (Aerodhramus fuciphagus) Ointment

“…This study was a follow-up study to determine the skin histopathological of diabetic rats with wounds by treating edible nest swiftlets ointment. Sandi & Musfirah (2019) proved that 30% edible nest swiftlets ointment was the most optimal for wound-healing in Alloxan-induced male rats when compared to Sanoskin Melladerm (positive control). Observation of histopathological preparations was carried out on day 0 when the wound was fresh or in the inflammatory stage.…”

“…Irma (2014) showed the wound healing effect of 10% edible nest swiftlets cream on mice, it can increase epithelialization and doesn't increase neovascularization after the fourth day of treatment. Sandi and Musfirah (2019) also showed 30% of edible nest swiftlets ointment has the optimal wound-healing effect in Alloxan-induced male rats.…”

Formulasi Dan Evaluasi Balsam Aroma Terapi Menggunakan Minyak Lemon (Oleum Citri. L) Dengan Cera Alba Sebagai Stabilizing Agent

“…Uji organoleptik merupakan pengujian yang dilakukan untuk melihat tampilan fisik dengan cara melakukan pengamatan terhadap tekstur, warna, bau atau aroma dari sediaan yang telah dibuat. Uji organoleptik dilakukan dengan cara mengamati sediaan balsem secara visual berdasarkan bentuk, warna dan bau (Sandi & Musfirah, 2019) Uji homogenitas dilakukan untuk mengecek apakah sediaan yang dibuat mengandung partikelpartikel kasar.prosedur ini dilakukan dengan cara Sediaan balsem dioleskan pada kaca arloji, sediaan harus menunjukkan susunan yang homogen dan tidak terlihat adanya gumpalan padat. Homogenitas formula balsam dinyatakan baik, ditandai dengan tidak adanya kotoran atau partikelpartikel kasar yang tertinggal pada kaca objek yang telah diolesi sediaan balsam.…”

Formulation of Edible Bird’s Nest (Aerodramus fuciphagus) from Central Kalimantan as Skin Whitening and Moisturizing Cream

“…EBN ( A. fuciphagus ) was soaked with distilled water for 10min, then it was steamed at a low temperature of 34°C (maximum 72°C for 10–15min). [ 2 10 ]…”

“…EBN has been proved to have a stimulant effect and wound-healing effect in alloxan-induced male rats. [ 1 2 ] In China, EBN is widely used for skin beauty because of its content such as carbohydrates, protein, fat, calcium, phosphorus, iron, and water. [ 3 4 ]…”