Wound Healing and Skin Regeneration

Takeo, Makoto; Lee, Wendy; Ito, Mayumi

doi:10.1101/cshperspect.a023267

Cited by 494 publications

(366 citation statements)

References 65 publications

(75 reference statements)

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“…When there is a physical insult to the skin, homeostatic turnover of the skin is temporarily halted and switches instead to a wound healing and reparative response (Ferguson and O'Kane, 2004; Hantash et al, 2008; Kawasumi et al, 2013; Reinke and Sorg, 2012; Takeo et al, 2015; Yates et al, 2012). The extent of the wound will determine the ultimate outcome; simple scratches can be effectively repaired but full-thickness skin wounds most commonly result in scar formation (Fig.…”

Section: The Mammalian Repair and Scar Formation Processmentioning

confidence: 99%

“…The extent of the wound will determine the ultimate outcome; simple scratches can be effectively repaired but full-thickness skin wounds most commonly result in scar formation (Fig. 2; Ferguson and O'Kane, 2004; Hantash et al, 2008; Kawasumi et al, 2013; Reinke and Sorg, 2012; Takeo et al, 2015; Yates et al, 2012). Indeed, wound healing in humans and most mammals results in a fibrotic response.…”

Section: The Mammalian Repair and Scar Formation Processmentioning

confidence: 99%

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Learning from regeneration research organisms: The circuitous road to scar free wound healing

Erickson

Echeverri

2018

Developmental Biology

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The skin is the largest organ in the body and plays multiple essential roles ranging from regulating temperature, preventing infection and ultimately defining who we are physically. It is a highly dynamic organ that constantly replaces the outermost cells throughout life. However, when faced with a major injury, human skin cannot restore a significant lesion to its original functionality, instead a reparative scar is formed. In contrast to this, many other species have the unique ability to regenerate full thickness skin without formation of scar tissue. Here we review recent advances in the field that shed light on how the skin cells in regenerative species react to injury to prevent scar formation versus scar forming humans.

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Section: The Mammalian Repair and Scar Formation Processmentioning

confidence: 99%

Section: The Mammalian Repair and Scar Formation Processmentioning

confidence: 99%

Learning from regeneration research organisms: The circuitous road to scar free wound healing

Erickson

Echeverri

2018

Developmental Biology

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“…Esto no ha sido ajeno al campo de la cicatrización de heridas, donde se buscan agentes que puedan acelerar este proceso mediante la estimulación de la proliferación y diferenciación celular incrementando los fibroblastos e inducción de la síntesis de colágeno (2) . El daño en la piel es generalmente asociado a procesos inflamatorios debido a lesiones agudas, como quemaduras, o lesiones crónicas como dermatitis atópica, acné vulgar o psoriasis (3) . Esto produce liberación de mediadores químicos, citoquinas, prostaglandinas y lípidos bioactivos que modulan la respuesta dolorosa e inflamatoria debido a la lesión celular (4) .…”

Section: Introductionunclassified

Efecto antiinflamatorio de la emulsión dermica del extracto etanólico de Peperomia choroniana D. CD. (ipitanki) en edema auricular inducido por xilol en ratones

Mayhuasca-Ysuhuaylas¹,

Arroyo-Acevedo²,

Franco-Quino³

2018

Rev. per. med. integr.

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Historia del artículo Información del artículo ResumenObjetivo. Evaluar el efecto antiinflamatorio de la emulsión dérmica del extracto etanólico de Peperomia choroniana en edema auricular inducido por xilol en ratones. Materiales y métodos. Estudio experimental. Se elaboró una emulsión dérmica del extracto etanólico de partes aéreas de Peperomia choroniana, la que se aplicó en ratones Swiss a quienes se les indujo inflamación con xilol. Se formaron seis grupos de seis ratones cada uno. El grupo I recibió crema base; el grupo II, dexametasona crema 0,05%; el grupo III, diclofenaco gel 1%; los grupos IV, V y VI, emulsión dérmica del extracto etanólico de Peperomia choroniana a las concentraciones de 0,1%, 0,5% y 1% respectivamente. Posterior a ello, se midieron los indicadores de edema auricular de ratones (Δpeso), inflamación cualitativa, temperatura auricular (ΔC°) y se realizó un estudio histopatológico. Resultados. Se encontró efecto antiinflamatorio en las emulsiones dermicas de Peperomia choroniana al 0,5% (54,6%) y al 1% (51,1%); asimismo, la emulsión dérmica al 0,5% redujo significativamente (p<0,05) la temperatura auricular (Δ3 °C). El estudio histopatológico mostró escaso infiltrado inflamatorio e incremento de fibroblastos en los grupos tratados con la emulsión a diferentes concentraciones. Conclusiones. La emulsión dérmica de Peperomia choroniana al 0,5% posee efecto antiinflamatorio tópico superior al diclofenaco gel 1%, pero inferior a la dexametasona crema 0,05% en la reducción de la inflamación y temperatura localizada. Palabras clave: Antiinflamatorios; Peperomia; Modelos animales; plantas medicinales (Fuente: DeCS).Anti-inflammatory effect of a dermal emulsion obtained from an ethanolic extract of Peperomia choroniana D. CD. (Ipitanki) on xylene-induced edema in mice AbstractObjective. To evaluate the anti-inflammatory effect of a dermal emulsion obtained from Peperomia choroniana ethanolic extract in xylene-induced ear edema in mice. Materials and Methods. An experimental study. Ear edema was induced with xylene in 36 Swiss mice, which were divided in six groups. Group I received basic cream; group II, dexamethasone cream 0.05%; Group III, diclofenac gel 1%; and Groups IV, V and VI received a dermal emulsion elaborated from an ethanolic extract of Peperomia choroniana aerial parts at concentrations of 0.1%, 0.5% and 1% respectively. After that, mouse ear edema (Δweight), qualitative inflammation and ear temperature (Δ°C) were measured and a histopathological study was developed. Results. An anti-inflammatory effect was founded on Peperomia choroniana dermal emulsions at 0.5% (54.6%) and 1% (51.1%); likewise, dermal emulsion at 0.5% significantly reduced handset temperature (Δ3 °C; p<0.05). The histopathological study showed a little inflammatory infiltrate and increased fibroblasts on treated groups at different concentrations. Conclusions. Peperomia choroniana dermal emulsion at 0.5% has more topical anti-inflammatory activity (reducing inflammation and localized temperature) than diclofenac ge...

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“…Wound healing comprises inflammatory, proliferative, and maturation phases, which involve interactions between various cell types and soluble factors [25,[39][40][41]. During the inflammatory phase, a variety of chemokines are released at the injured site, leading to the recruitment of inflammatory cells, such as neutrophils and macrophages.…”

Section: Biomarkers Of Wound Agingmentioning

confidence: 99%

Vitality and wound-age estimation in forensic pathology: review and future prospects

Bai

et al. 2018

Forensic Sciences Research

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Determining the age of a wound is challenging in forensic pathology, but it can contribute to the reconstruction of crime scenes and lead to arrest of suspects. Forensic scholars have tended to focus on evaluating wound vitality and determining the time elapsed since the wound was sustained. Recent progress in forensic techniques, particularly high-throughput analyses, has enabled evaluation of materials at the cellular and molecular levels, as well as simultaneous assessment of multiple markers. This paper provides an update on wound-age estimation in forensic pathology, summarizes the recent literature, and considers useful additional information provided by each marker. Finally, the future prospects for estimating wound age in forensic practise are discussed with the hope of providing something useful for further study.

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Wound Healing and Skin Regeneration

Cited by 494 publications

References 65 publications

Learning from regeneration research organisms: The circuitous road to scar free wound healing

Learning from regeneration research organisms: The circuitous road to scar free wound healing

Efecto antiinflamatorio de la emulsión dermica del extracto etanólico de Peperomia choroniana D. CD. (ipitanki) en edema auricular inducido por xilol en ratones

Vitality and wound-age estimation in forensic pathology: review and future prospects

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