Historia del artículo Información del artículo ResumenObjetivo. Evaluar el efecto antiinflamatorio de la emulsión dérmica del extracto etanólico de Peperomia choroniana en edema auricular inducido por xilol en ratones. Materiales y métodos. Estudio experimental. Se elaboró una emulsión dérmica del extracto etanólico de partes aéreas de Peperomia choroniana, la que se aplicó en ratones Swiss a quienes se les indujo inflamación con xilol. Se formaron seis grupos de seis ratones cada uno. El grupo I recibió crema base; el grupo II, dexametasona crema 0,05%; el grupo III, diclofenaco gel 1%; los grupos IV, V y VI, emulsión dérmica del extracto etanólico de Peperomia choroniana a las concentraciones de 0,1%, 0,5% y 1% respectivamente. Posterior a ello, se midieron los indicadores de edema auricular de ratones (Δpeso), inflamación cualitativa, temperatura auricular (ΔC°) y se realizó un estudio histopatológico. Resultados. Se encontró efecto antiinflamatorio en las emulsiones dermicas de Peperomia choroniana al 0,5% (54,6%) y al 1% (51,1%); asimismo, la emulsión dérmica al 0,5% redujo significativamente (p<0,05) la temperatura auricular (Δ3 °C). El estudio histopatológico mostró escaso infiltrado inflamatorio e incremento de fibroblastos en los grupos tratados con la emulsión a diferentes concentraciones. Conclusiones. La emulsión dérmica de Peperomia choroniana al 0,5% posee efecto antiinflamatorio tópico superior al diclofenaco gel 1%, pero inferior a la dexametasona crema 0,05% en la reducción de la inflamación y temperatura localizada. Palabras clave: Antiinflamatorios; Peperomia; Modelos animales; plantas medicinales (Fuente: DeCS).Anti-inflammatory effect of a dermal emulsion obtained from an ethanolic extract of Peperomia choroniana D. CD. (Ipitanki) on xylene-induced edema in mice AbstractObjective. To evaluate the anti-inflammatory effect of a dermal emulsion obtained from Peperomia choroniana ethanolic extract in xylene-induced ear edema in mice. Materials and Methods. An experimental study. Ear edema was induced with xylene in 36 Swiss mice, which were divided in six groups. Group I received basic cream; group II, dexamethasone cream 0.05%; Group III, diclofenac gel 1%; and Groups IV, V and VI received a dermal emulsion elaborated from an ethanolic extract of Peperomia choroniana aerial parts at concentrations of 0.1%, 0.5% and 1% respectively. After that, mouse ear edema (Δweight), qualitative inflammation and ear temperature (Δ°C) were measured and a histopathological study was developed. Results. An anti-inflammatory effect was founded on Peperomia choroniana dermal emulsions at 0.5% (54.6%) and 1% (51.1%); likewise, dermal emulsion at 0.5% significantly reduced handset temperature (Δ3 °C; p<0.05). The histopathological study showed a little inflammatory infiltrate and increased fibroblasts on treated groups at different concentrations. Conclusions. Peperomia choroniana dermal emulsion at 0.5% has more topical anti-inflammatory activity (reducing inflammation and localized temperature) than diclofenac ge...
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