Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts

Investigation of Acute Effects of Hypericum Perforatum (Kantaron) Treatment in Experimental Thermal Burns and Comparison with Silver Sulfadiazine Treatment

“…It is emphasized for the effect of HP that "wound-healing activity of HP extract may be a result of the fibroblast migration and stimulation of collagen synthesis and does not seem to be related to mitotic activity". [20] "However, its effects on epithelization during wound-healing await for further investigations in terms of mechanism of action since previous in vivo experiments with HP extracts have provided evidence for the effect on epithelization. Further studies are recommended to understand responsible compound(s) of HP for wound-healing".…”

“…Further studies are recommended to understand responsible compound(s) of HP for wound-healing". [20] The progression from an injured site to a healed wound is potentially slowed or arrested by a number of different events and conditions. One event that impedes wound healing is colonization of the wound bed by micro-organisms.…”

Comparison of the healing effects of silver sulfadiazine cream 1% and the essential oil of Hypericum perforatum on scald burn wound in a rat model

“…In the study performed in 2010 by Süntar et al [9], it has been also showed that fibroblast and collagen increases were more in the extract of Hypericum perforatum. When the activity of chicken embryo fibroblast was evaluated in the study performed by Öztürk et al [10], it has been showed that Hypericum perforatum plant extract increased collagen synthesis of fibroblast and accelerated the forming of polygonal collagen. Because of the effects seen on wound healing was likewise on the burn wound, we suggest that the plant would be tried in the burn treatment.…”

Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery

“…H. perforatum has been traditionally used as an aromatic, expectorant, anxiolytic, sedative and anti-inflammatory to treat bladder complaints, chronic catarrh, colds, diarrhoea, jaundice, rheumatism, menopause, worms and nervous depression [16,39]. H. perforatum has been widely tested in vivo and in vitro for a variety of pharmacological effects such as antibacterial, anti-inflammatory [40], wound-healing [41,42], antitumoral [43], antiviral [44], inhibition of dopamine and norepinephrine reuptake [45], reduction of neuropathic pain [46] and treatment of mild-to-moderate depression [47,48] among others. Hydroalcoholic extracts of H. perforatum contain naphtodianthrones, flavonoids, phenylpropanes, phloroglucinols, proanthocyanidins secondary, tannins [40] but it is known that the activities mentioned before are mainly mediated by a single or a combination of hypericin, pseudohypericin and/or hyperforin (Fig.…”