Wound healing activity of <i>Streptocaulon juventas</i> root ethanolic extract

Nguyen, Minh Can; Le, Dang Thi Thanh; Kamei, Kaeko; Thảo, Đặng Thị Phương

doi:10.1111/wrr.12599

Cited by 9 publications

(6 citation statements)

References 39 publications

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“…Hence the poly-herbal formulation showed a significant antioxidant property as compared with various standards like ascorbic acid or butylated hydroxytoluene. The endothelial dysfunctions due to hyperlipidemia, hyperinsulinemia, and hyperglycemia are the result of oxidative stress [28]. The reduction of antioxidant enzymes, inactivation of enzymes and lipid peroxidation cause cell death while free radicals get excess produces.…”

Section: Discussionmentioning

confidence: 99%

A Novel PolyHerbal Formulation Hastens Diabetic Wound Healing with Potent Antioxidant Potential: A Comprehensive Pharmacological Investigation

Majumder¹,

Paridhavi²

2018

Nat Prod Chem Res

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This investigation aimed to evaluate the wound healing and antioxidant potentials of the novel Poly-herbal Formulation (PHF) in diabetic rat's models and in-vitro antioxidant assays respectively. The wound models viz., excision, incision and dead space by using wistar strain albino rats were adopted for this investigation. The free radical scavenging assays were employed for investigation of Antioxidant potential. The constraints studied for assessment of wound repair were percentage closing percentage of wound, tensile strength of repaired tissue, breaking strength of granulation tissue and valuation of hydroxyproline content on dried tissue. The histopathological sections of granulation tissues obtained in dead space wound model were studied for the distribution of collagen and other histopathological changes. Four groups were used in this study with six animals each. Group I and Group II acts as normal control and diabetic control whereas Group III and Group IV was used as glibenclamide treated (1 mg/kg b.w.), and PHF (500 mg/kg b.w.) treated group respectively. On the other hand the various antioxidant assays like DPPH, scavenging assays, hydrogen peroxide assay etc. were investigated. The PHF has been significantly healing the wounds in diabetic rats within 18 days, while diabetic control rats healed the wound about 86.12 %. Significant (p<0.01) increase in wound breaking strength as well as epithelialization and the level of hydroxyproline was observed in PHF treated animals comparison with diabetic control group. PHF has also shown significant antioxidant potential in in-vitro assays. All these investigations indicate the significant wound healing and antioxidant potential of PHF.

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Section: Discussionmentioning

confidence: 99%

A Novel PolyHerbal Formulation Hastens Diabetic Wound Healing with Potent Antioxidant Potential: A Comprehensive Pharmacological Investigation

Majumder¹,

Paridhavi²

2018

Nat Prod Chem Res

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“…[2,[5][6][7][8][9] External application of SJ significantly promoted wound healing via anti-inflammatory and inducing fibroblast proliferation and angiogenesis. [10] Our previous research also demonstrated that topical use of SJ extracts accelerated wound healing via activating the AKT-mTOR and ERK-p38 signaling pathways, thereby promoting fibroblast proliferation, migration, and collagen synthesis. [11] However, the method for the determination of SJ's active components is rarely reported.…”

Section: Introductionmentioning

confidence: 92%

Determination of Two Wound Healing Components in Streptocaulon juventas (Lour.) Merr.: Periplogenin and Digitoxigenin

Li,

Feng,

Qiu

2023

Chemistry & Biodiversity

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Streptocaulon juventas (Lour.) Merr. (SJ) is a herbal medicine can promote wound healing. Cardiac glycosides, especially periplogenin, digitoxigenin, and their glycosides were the main constituents of SJ. We aim to establish a method for the simultaneous determination of periplogenin and digitoxigenin in SJ and evaluate the wound healing activities of these two components. UPLC‐QqQ‐MS/MS was used for the determination of periplogenin and digitoxigenin. Meanwhile, rats were subjected to full‐thickness skin resection on the back to investigate the wound healing effects of periplogenin and digitoxigenin. The content of periplogenin and digitoxigenin in 13 batches of SJ extracts ranged from 43.26 to 97.15 μg/g and 18.04 to 55.55 μg/g, respectively. Periplogenin and digitoxigenin significantly increased the rate of wound healing in rats, increased the content of hydroxyproline in wound tissue, and improved the pathological state of wound skin tissue.

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“…Merr. root ethanolic extract was evaluated in the mouse excision wound model ( Nguyen et al, 2017 ). Results showed that topical administration of the extract (100 mg/kg/day) remarkably reduced the wound closure time.…”

Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

“…Merr. extract ( Nguyen et al, 2017 ). Taken together, it was deduced that Streptocaulon juventas (Lour.)…”

Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

et al. 2022

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Chronic and unhealed wound is a serious public problem, which brings severe economic burdens and psychological pressure to patients. Various botanical drugs in traditional Chinese medicine have been used for the treatment of wounds since ancient time. Nowadays, multiple wound healing therapeutics derived from botanical drugs are commercially available worldwide. An increasing number of investigations have been conducted to elucidate the wound healing activities and the potential mechanisms of botanical drugs in recent years. The aim of this review is to summarize the botanical drugs in traditional Chinese medicine with wound healing properties and the underlying mechanisms of them, which can contribute to the research of wound healing and drug development. Taken together, five botanical drugs that have been developed into commercially available products, and 24 botanical drugs with excellent wound healing activities and several multiherbal preparations are reviewed in this article.

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Wound healing activity of Streptocaulon juventas root ethanolic extract

Cited by 9 publications

References 39 publications

A Novel PolyHerbal Formulation Hastens Diabetic Wound Healing with Potent Antioxidant Potential: A Comprehensive Pharmacological Investigation

A Novel PolyHerbal Formulation Hastens Diabetic Wound Healing with Potent Antioxidant Potential: A Comprehensive Pharmacological Investigation

Determination of Two Wound Healing Components in Streptocaulon juventas (Lour.) Merr.: Periplogenin and Digitoxigenin

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

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