Wound Healing Activity of Ethanolic Extract of Selaginella Bryopteris on Rats

Paswan, Shravan Kumar; Srivastava, Sajal; Rao, Chandana Venkateswara

doi:10.5530/pj.2019.11.155

Cited by 5 publications

(5 citation statements)

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“…However, wound healing medications remain unsatisfactory due to its high cost, low availability, limited efficacy, and various side effects [ 9 ]. Medicinal plants are widely used in folk medicine and many researchers have reported improvement in wound healing process by various plant extracts and isolated compounds; which, has provided healing wounds products more affordable with greater safety against hypersensitive reactions compared to synthetic pharmaceutical agents [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Wound healing by topical application of Momordica charantia L. formulations on mice

et al. 2021

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Background and Aim: Momordica charantia is mainly characterized by its antimicrobial and antioxidant properties. The current study aimed to evaluate the healing activity of gel and cream formulations based on M. charantia on induced wounds in mice. Materials and Methods: Acetonic extract of M. charantia was prepared and incorporated into gel and cream formulations. Mus musculus Balb/c (n=30) with induced injury were distributed into five groups: Group I (control – day 7), Group II (control – day 14), Group III (1% gel – day 7), and Group IV (1% gel – day 14) to which 1% M. charantia gel was dermally applied daily for 7 and 14 days, respectively, Group V (1% cream – day 7) and Group VI (1% cream – day 14) to which of M. charantia 1% cream were dermally applied daily for 7 and 14 days, respectively. Time of wound closure was determined during the experimentation; rats were euthanized with sodium pentobarbital 60 mg/kg/pc v.ip. for obtaining skin samples for histopathological analysis. Results: Groups IV and VI showed a higher percentage of wound closure on day 14, and in histopathological analysis, effect was greater in Group VI with the presence of fibroblasts and abundant collagen and elastic fibers. Conclusion: M. charantia gel and cream showed wound healing activity on induced wounded mice; the most effective treatment was M. charantia 1% cream formulation.

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Section: Introductionmentioning

confidence: 99%

Wound healing by topical application of Momordica charantia L. formulations on mice

et al. 2021

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“…Furthermore, these compounds have been shown to increase collagen synthesis, decreasing the overproduction of free radicals, facilitating oxygen diffusion, and increasing lymphatic drainage, an important event that occurs to improve wound healing. [48][49] Likewise, the chlorogenic acid reported in S. tuberosum, improves the wound healing activity, by acting to produce higher capillary density and promoting the production of collagen. Added to this are its antioxidant and free radical scavenger effects on oxidative parameters, and antiinflammatory effects on extracellular matrix metalloproteinases (MMP) in wound tissues.…”

Section: Discussionmentioning

confidence: 99%

Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c

Rosas-Cruz¹,

Silva-Correa²,

Calderón-Peña³

et al. 2020

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This study has the purpose to evaluate the effect of an ointment made from the ethanolic extract of S. tuberosum L. var. "Tumbay yellow potato" on skin induced wounds of Mus musculus Balb/c. MATERIALS AND METHODS Biological material Mus musculus Balb/c (30-35 g) males, 12-14 weeks old, obtained from the Instituto Nacional de Salud (INS), were used for this investigation. All mice were kept in individual cages and standard photoperiod environmental conditions (12:12 dark: light cycle) ABSTRACT Background: Solanum tuberosum L. is an Andean tuber that is mainly characterized by its antioxidant properties. Objective: To evaluate the healing activity of an S. tuberosum-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of S. tuberosum "Tumbay yellow potato" were prepared, which were incorporated into 1% and 2% ointment formulations. Mus musculus Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 % and 2% of S. tuberosum extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. Results: Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. Conclusions: S. tuberosum ointments show healing activity in induced wounds in mice, the most effective treatment being the 2% ointment formulation.

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“…Plants also provide boundless prospects for the discovery of new drugs via different ways depending on the availability of chemical diversity. The plants are a source of novel antibiotics and people choose herbal medicines because of the adverse side effects associated with synthetic antibioticsParekh and Chanda, 2007; Paswan et al, 2019.With this insight, we analyzed the antibacterial e ciency of Bergera koenigii extracts. The highest zone of inhibition was observed in methanol extract with 15 ± 1.7 mm against the Gram-positive organism S. aureus.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Phytochemical profiling, anti-oxidant, antimicrobial and cytotoxic evaluation of Bergera koenigii seed extracts against Leukemic cancer

Govindswamy

2024

Preprint

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Traditional herbs have always been pioneers in the development of new therapeutics. According to Ayurveda, India has always been a hub of many herbs and shrubs that possess numerous polyphenols and flavonoids with promising anticancer, antioxidant, and antibacterial properties. The present study aimed to elucidate the anticancer activity of various methanol, ethanol and petroleum ether extracts of Bergera koenigii seeds against THP-1 cells. In addition to phytochemical analysis, total phenol and flavonoid content (TPC, TFC) and antioxidant assays were also performed to estimate the potential of the Bergera koenigii seeds. Among these, the methanolic extract of Bergera koenigii seeds inhibited leukemic THP-1 cells due to the presence of bioactive compounds such as hexadecanoic acid, octadecadienoic acid, octadecatrienoic acid, tricosanoic acid and γ-sitosterol, as revealed by GC‒MS analysis. According to the radical scavenging capacity, both hexadecanoic acid and octadecadienoic acid exhibited the highest anticancer activity, with IC50 values of 15±8.37 and 15±0.23 µg/ml, respectively. Additionally, the methanolic extract had a TPC of 959.97 mg/GAE and a TFC of 1443.20 mg/QE, and the antioxidant activity had an IC50 value of 369.09, Antibacterial activity with 10 ± 0.5 mmEscherichia coli, 8 ± 0.82 mm for Pseudomonas aeruginosa and15 ± 1.7 mm for Staphylococcus aureus. Thus, the above results indicate that the methanolic extracts of Bergera koenigii seeds are more promising drugs against leukemic THP-1 cell lines than are the chloroform and pet ether extracts.

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Wound Healing Activity of Ethanolic Extract of Selaginella Bryopteris on Rats

Cited by 5 publications

References 0 publications

Wound healing by topical application of Momordica charantia L. formulations on mice

Wound healing by topical application of Momordica charantia L. formulations on mice

Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c

Phytochemical profiling, anti-oxidant, antimicrobial and cytotoxic evaluation of Bergera koenigii seed extracts against Leukemic cancer

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