Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c

Rosas-Cruz, Galy P; Silva-Correa, Carmen R.; Calderón-Peña, Abhel A.; Torre, Víctor E. Villarreal-La; Aspajo-Villalaz, Cinthya L.; Cruzado-Razco, José L.; Rosario-Chávarri, Jorge Del; Rodríguez-Soto, Juan Carlos; Pretel-Sevillano, Orlando; Sagástegui-Guarniz, William Antonio; González-Siccha, Anabel D.

doi:10.5530/pj.2020.12.175

Cited by 13 publications

(25 citation statements)

References 35 publications

(35 reference statements)

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“…Before performing induction of wounds, all back of mice were depilated, 48 h later, lidocaine 2% cream was applied topically as an anesthetic, and a cut of 1 mm deep and 1 cm long, was made parallel to the longitudinal axis in the dorsal zone of each mouse. Each cut was measured with the help of a Vernier caliper [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…After 7 and 14 days of treatment, the experimental animals were euthanized using sodium pentobarbital 60 mg/kg intraperitoneal injection; then, skin samples were obtained by making cuts of 1 cm long and 0.5 cm long wide around the scar. Samples were preserved in sterile flasks with 10% formaldehyde solution for 8 days, and then, 3-5 μm parts were selected and fixed in paraffin [ 24 ]. Samples were stained with hematoxylin-eosin for reading under the microscope at ×400.…”

Section: Methodsmentioning

confidence: 99%

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Wound healing by topical application of Momordica charantia L. formulations on mice

et al. 2021

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Background and Aim: Momordica charantia is mainly characterized by its antimicrobial and antioxidant properties. The current study aimed to evaluate the healing activity of gel and cream formulations based on M. charantia on induced wounds in mice. Materials and Methods: Acetonic extract of M. charantia was prepared and incorporated into gel and cream formulations. Mus musculus Balb/c (n=30) with induced injury were distributed into five groups: Group I (control – day 7), Group II (control – day 14), Group III (1% gel – day 7), and Group IV (1% gel – day 14) to which 1% M. charantia gel was dermally applied daily for 7 and 14 days, respectively, Group V (1% cream – day 7) and Group VI (1% cream – day 14) to which of M. charantia 1% cream were dermally applied daily for 7 and 14 days, respectively. Time of wound closure was determined during the experimentation; rats were euthanized with sodium pentobarbital 60 mg/kg/pc v.ip. for obtaining skin samples for histopathological analysis. Results: Groups IV and VI showed a higher percentage of wound closure on day 14, and in histopathological analysis, effect was greater in Group VI with the presence of fibroblasts and abundant collagen and elastic fibers. Conclusion: M. charantia gel and cream showed wound healing activity on induced wounded mice; the most effective treatment was M. charantia 1% cream formulation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Wound healing by topical application of Momordica charantia L. formulations on mice

et al. 2021

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“…The results were expressed as mg of gallic acid equivalents (GAE)/g extract. [22][23] Determination of antioxidant activity DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay was used to evaluate the antioxidant activity of ethanol extract of A. cherimola. Ascorbic acid was used as standard.…”

Section: Determination Of Total Phenolics Compounds (Tp)mentioning

confidence: 99%

“…After 30 min incubation at room temperature in a dark room, absorbance was read at 517 nm using a microplate reader and methanol was used as blank. 22 All tests were performed in triplicate and scavenging ability (%) was calculated as follows:…”

Section: Determination Of Total Phenolics Compounds (Tp)mentioning

confidence: 99%

Antioxidant and Hepatoprotective Activity of Ethanol Extract of Annona cherimola Mill. On Paracetamol-Induced Liver Toxicity in Rats

Silva-Correa¹,

Torre²,

Cruzado-Razco³

et al. 2021

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species (ROS) and antioxidant enzymes, causing severe liver damage. 5,7,8 Given that, natural products are attracting the interest of many researchers to determine their potential usefulness for the treatment of liver diseases. 4 Some plants have been studied for their hepatoprotective activity, these plants include Silybum marianum, Glycyrrhiza glabra, Phyllanthus species (P. amarus, P. niruri, P. emblica) and Rosmarinus officinalis, Psidium guajava, Picrorhiza kurroa. 1,9 Annona cherimola Mill. (A. cherimola) known as "anona" or "cherimoya", belongs to the Annonaceae family and is an exotic fruit found in different subtropical areas around the world. 10-11 A. cherimola has not been well studied, but it is known that its fruits have antioxidant and cytoprotective properties due to their content of phenolic compounds. The decoction of its leaves is traditionally used as antiinflammatory, lipid-lowering, antimicrobial, digestive and hepatoprotective. [12][13][14][15] The chemical compounds reported in A. cherimola are the compounds Cherimolacyclopeptide D, cherimolacyclopeptide E, rutina, acetogeninas como Aromin-A, cherianoine, cherimoline, cheritamine, annomolin, annocherimolin, anonaine andasimilobine, lanuginosina, liriodenina, lisicamina, pronuciferina y esteparina. [16][17][18][19][20][21]

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“…The results were expressed as mg Gallic acid equivalents (GAE)/g extract. 10 Evaluation of gastric antiulcer activity…”

Section: Preparation Of the Hydroalcoholic Extractmentioning

confidence: 99%

Total Phenol Content and Gastric Anti-Ulcer Activity of Hydroalcoholic Extract of Persea caerulea (Ruiz & Pav.) Mez. Bark

Calderón-Peña¹,

Aspajo-Villalaz²,

Silva-Correa³

et al. 2021

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Objective: Determine the content of total phenols and evaluate the gastroprotective effect of the extract of Persea caerulea (Ruiz & Pav.) Mez. in mice with induced gastric ulcer. Material and Methods: The bark of Persea caerulea was macerated in 70% ethanol and the phenol content was determined using the Folin-Ciocalteu method. The female Mus musculus Balb/c specimens were distributed in the following groups: White Control Group, without indomethacin dosing; Negative Control Group, dosing with indomethacin; Positive Control Group treated with ranitidine at a dose of 50 mg/kg; Groups P. caerulea treated with extract at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg. Gastric ulcer was induced with indomethacin orally at a dose of 50 mg/kg, the procedure was repeated 12 hours later; Gastroprotective treatment was administered 60 minutes after each dose of indomethacin, 6 hours after the last dose, sodium pentobarbital was euthanized and the stomach was resected to determine ulceration using the Marhuenda Scale. Results: Higher percentages of gastric ulcer inhibition were obtained in the P. caerulea 100 mg/kg (80%) and P. caerulea 200 mg/kg (85.71%) groups. Conclusions: Extract of Persea caerulea (Ruiz & Pav.) Mez., At doses of 100 and 200 mg/kg of body weight, has a gastric antiulcerative effect which is related to its content of total polyphenols.

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Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c

Cited by 13 publications

References 35 publications

Wound healing by topical application of Momordica charantia L. formulations on mice

Wound healing by topical application of Momordica charantia L. formulations on mice

Antioxidant and Hepatoprotective Activity of Ethanol Extract of Annona cherimola Mill. On Paracetamol-Induced Liver Toxicity in Rats

Total Phenol Content and Gastric Anti-Ulcer Activity of Hydroalcoholic Extract of Persea caerulea (Ruiz & Pav.) Mez. Bark

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