Antioxidant and Hepatoprotective Activity of Ethanol Extract of Annona cherimola Mill. On Paracetamol-Induced Liver Toxicity in Rats

Abstract

species (ROS) and antioxidant enzymes, causing severe liver damage. 5,7,8 Given that, natural products are attracting the interest of many researchers to determine their potential usefulness for the treatment of liver diseases. 4 Some plants have been studied for their hepatoprotective activity, these plants include Silybum marianum, Glycyrrhiza glabra, Phyllanthus species (P. amarus, P. niruri, P. emblica) and Rosmarinus officinalis, Psidium guajava, Picrorhiza kurroa. 1,9 Annona cherimola Mill. (A. cherimola) known as "anona" or "cherimoya", belongs to the Annonaceae family and is an exotic fruit found in different subtropical areas around the world. 10-11 A. cherimola has not been well studied, but it is known that its fruits have antioxidant and cytoprotective properties due to their content of phenolic compounds. The decoction of its leaves is traditionally used as antiinflammatory, lipid-lowering, antimicrobial, digestive and hepatoprotective. [12][13][14][15] The chemical compounds reported in A. cherimola are the compounds Cherimolacyclopeptide D, cherimolacyclopeptide E, rutina, acetogeninas como Aromin-A, cherianoine, cherimoline, cheritamine, annomolin, annocherimolin, anonaine andasimilobine, lanuginosina, liriodenina, lisicamina, pronuciferina y esteparina. [16][17][18][19][20][21]