UHPLC-Q/Orbitrap/MS based chemical fingerprinting and hepatoprotective potential of a medicinal plant, Morinda angustifolia Roxb.

Hasan, Md. Mehedi; Zilani, Md. Nazmul Hasan; Akter, Sheuly; Nasrin, Papia; Shajib, Gazi Mohammad Al; Islam, Md. Aminul; Biswas, Partha; Mahmud, Shafi; Saleh, Md. Abu; Hasan, Md. Nazmul; Uddin, Shaikh Jamal; Shilpi, Jamil Ahmad

doi:10.1016/j.sajb.2022.05.037

Cited by 12 publications

(6 citation statements)

References 36 publications

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“…The scarcity of safety and effectiveness is the main reason for failure, which is usually associated with absorption, distribution, metabolism, excretion, and toxicity properties. For this purpose, ADMET profiling is used for rapid ADMET test of the selected compounds to reduce the failure of the drug development process ( Biswas et al, 2022a , Dong et al, 2018 , Hasan et al, 2022a , Hasan et al, 2022b ). Forty-three compounds were obtained from M. sinensis & A. villosus, of which eight compounds, including six selected compounds and two control, the ADMET properties are computed by web-based servers such as SwissADME and pkCSM detailed in Table 5 .…”

Section: Discussionmentioning

confidence: 99%

Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence

Nur Kabidul Azam,

Biswas,

Mohaimenul Islam Tareq

et al. 2024

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 99%

Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence

Nur Kabidul Azam,

Biswas,

Mohaimenul Islam Tareq

et al. 2024

Saudi Pharmaceutical Journal

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“…As part of the study’s pharmacokinetic components, Lipinski’s five-rule pharmacophore properties (molecular weight, rotational bond count, logP value, hydrogen bond donors and acceptors, and degree of infringement) were evaluated for all selected ligands using Lipinski’s five-rule approach (violation level) [ 72 , 73 , 74 ]. All the selected natural bioactive phytochemicals possessed better human intestinal absorption, better BBB value, AMES toxicity, no carcinogenicity, and no hepatotoxicity for both the human and mice research model, except for the selected control compound for our research study [ 75 , 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development Approach

Biswas¹,

Bibi

Yousafi

et al. 2023

Molecules

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An evaluation of the expression and predictive significance of the MDM2 gene in brain lower-grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several transcriptome servers were used to measure the differential expression of the targeted MDM2 gene and search mutations and copy number variations. GENT2, Gene Expression Profiling Interactive Analysis, Onco-Lnc, and PrognoScan were used to figure out the survival rate of LGG cancer patients. The protein–protein interaction networks between MDM2 gene and its co-expressed genes were constructed by Gene-MANIA tool. Identified bioactive phytochemicals were evaluated through molecular docking using Schrödinger Suite Software, with the MDM2 (PDB ID: 1RV1) target. Protein–ligand interactions were observed with key residues of the macromolecular target. A molecular dynamics simulation of the novel bioactive compounds with the targeted protein was performed. Phytochemicals targeting MDM2 protein, such as Taxifolin and (-)-Epicatechin, have been shown with more highly stable results as compared to the control drug, and hence, concluded that phytochemicals with bioactive potential might be alternative therapeutic options for the management of LGG patients. Our once informatics-based designed pipeline has indicated that the MDM2 gene may have been a predictive biomarker for LGG cancer and selected phytochemicals possessed outstanding interaction results within the macromolecular target’s active site after utilizing in silico approaches. In vitro and in vivo experiments are recommended to confirm these outcomes.

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“…Some compounds namely gambogic acid, gossypol, fisetin, phenethyl‐isothiocyanate, lutein, quercetin, sanguinarine, apigenin, punicalagin, triptolide are among the phytochemicals that block the NF‐kB pathway (Pang et al, 2011; Szliszka et al, 2011; Xiao et al, 2006; Yi et al, 2008). Many bioactive substances have been found to lower the risk of PCa by taking part in the control of redox signaling pathways and modifying the amounts of dangerous ROS, the experimental research works are taken place in cell lines, or model organisms (Hasan et al, 2022; Shukla et al, 2015). Apart from this, angiogenesis is a key part of how PCa spreads and how it will be treated, and it is significantly influenced by the cytokine vascular endothelial growth factor (VEGF), which is generated by tumor cells (Garcia et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities

Mia,

Dey,

Sakib

et al. 2023

Phytotherapy Research

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Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number of PCa patients continues to rise despite the availability of effective treatments in recent decades. The current therapy with chemotherapeutic drugs has been largely ineffective due to multidrug resistance and the conventional treatment has restricted drug accessibility to malignant tissues, necessitating a higher dosage resulting in increased cytotoxicity. Plant‐derived bioactive compounds have recently attracted a great deal of attention in the field of PCa treatment due to their potent effects on several molecular targets and synergistic effects with anti‐PCa drugs. This review emphasizes the molecular mechanism of phytochemicals on PCa cells, the synergistic effects of compound‐drug interactions, and stem cell targeting for PCa treatment. Some potential compounds, such as curcumin, phenethyl‐isothiocyanate, fisetin, baicalein, berberine, lutein, and many others, exert an anti‐PCa effect via inhibiting proliferation, metastasis, cell cycle progression, and normal apoptosis pathways. In addition, multiple studies have demonstrated that the isolated natural compounds: d‐limonene, paeonol, lanreotide, artesunate, and bicalutamide have potential synergistic effects. Further, a significant number of natural compounds effectively target PCa stem cells. However, further high‐quality studies are needed to firmly establish the clinical efficacy of these phytochemicals against PCa.

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UHPLC-Q/Orbitrap/MS based chemical fingerprinting and hepatoprotective potential of a medicinal plant, Morinda angustifolia Roxb.

Cited by 12 publications

References 36 publications

Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence

Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence

Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development Approach

The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities

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