Wound Contraction and Fibrocontractive Disorders

Ariyan, Stephan

doi:10.1001/archsurg.1978.01370210016002

Cited by 40 publications

(11 citation statements)

References 11 publications

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“…Nearly all investigators of cell contractility in collagen gels have used fibroblasts from skin or non-wound tissue (Bell ct al., 1979;Clark et al, 1989;Ehrlich and White, 1983;Montesano and Orci, 1988). In many instances where contraction or contracture occurs, investigators have identified a modified fibroblast which difyers from a normal fibroblast in its morphology (Gabbiani, 1981;Rudolph, 1980;Ariyan et al, 1978;Majno et al, 1971) and cytoskeletal protein content (Ryan et al, 1974). These cells has been observed in human granulation tissue (Ryan et al, 1974), in Peyronie's disease (Ariyan et al, 1978), in Dupuytren's contracture (Gabbiani and Majno, 1972), and in breast capsule contraction around implants (Ariyan et al, 1978), to name a few instances.…”

Section: Discussionmentioning

confidence: 99%

Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors

Finesmith

Broadley

Davidson

1990

Journal Cellular Physiology

108

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Wound contraction is one function of granulation tissue which is critical to repair. This study compares the ability of fibroblast-like cells derived from granulation tissue of various ages to contract a tissue equivalent, or a collagen gel, and examines the influence of growth factors implicated in wound repair on collagen gel contraction by these different cell populations. Cells from older granulation tissue (21 and 28 days) have an enhanced ability to contract a tissue equivalent when compared to cells from younger granulation tissue (7 and 14 days) or normal rat skin fibroblasts. Transforming growth factor-beta 1 (TGF-beta 1) enhanced contractility most in those cells which had a greater basal contractile ability. While basic fibroblast growth factor (bFGF) alone had moderately stimulatory effects at low doses (0.1-1.0 ng/ml), higher doses (greater than or equal to 10 ng/ml) inhibited basal contraction. Pretreatment with bFGF followed by exposure to TGF-beta 1, with or without the continued presence of bFGF, delayed gel contraction by cells from skin and early granulation tissue, but bFGF enhanced TGF-beta 1 activity in highly contractile cells. Transforming growth factor-alpha moderately enhanced contraction by cells from older granulation tissue. While both TGF-beta 1 and bFGF enhanced wound repair, their differential effects on the fibroblast-like cell derived from granulation tissue of different ages suggest that phenotypic differences exist between these cell populations. In addition, our results predict significant interactions between polypeptide cytokines at the site of repair.

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Section: Discussionmentioning

confidence: 99%

Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors

Finesmith

Broadley

Davidson

1990

Journal Cellular Physiology

108

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“…It has been described as being pushed toward the conjunctiva by the aqueous pressure, thereby creating a dome‐shaped bleb (Scott & Quigley 1988). This is different from bleb scarring, where flattening of the bleb wall is evident because of myofibroblast contraction (Ariyan et al. 1978).…”

Section: Discussionmentioning

confidence: 89%

Stratus optical coherence tomography study of filtering blebs after primary trabeculectomy with a fornix‐based conjunctival flap

Hirooka

Takagishi

Baba

et al. 2010

Acta Ophthalmologica

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ABSTRACT.Purpose: To investigate the relationship between filtering bleb function and Stratus optical coherence tomography (OCT) images. Methods: We studied 72 eyes of 65 consecutive patients who had a fornixbased conjunctival flap in primary trabeculectomy with mitomycin C (MMC). Filtering blebs with various types of glaucoma were examined using Stratus OCT. Success rates were defined as intraocular pressure (IOP) £ 15 mmHg and IOP reduction ‡ 25% without medication or additional surgery. Success rates among classified groups were compared using Kaplan-Meier survival curves and the log-rank test. Results: Blebs were classified into three different categories on the basis of the following Stratus OCT patterns: cystoid type (multiple cysts inside the bleb; 17 eyes), diffuse type (low to high reflective areas that were mixed inside the bleb; 31 eyes) and layer type (medium to high reflective layer inside the bleb; 24 eyes). Success rates in the cystoid-, diffuse-and layer-type blebs were 94%, 97% and 75% (P = 0.02), respectively. Conclusion: In trabeculectomy with MMC and a fornix-based conjunctival flap, there is a significant association between the success rates and the postoperative Stratus OCT findings of filtering blebs.

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“…Carcinoma-associated fibroblasts: the new paradigm for therapeutic approach in HNSCC S Routray et al Figure 1 Tumor microenvironment, the role of CAFs, TAMs, and HIF, and its effects related to the tumor progression Epithelial cells Abe et al, 2001;Metz, 2003; Circulating fibrocytes Gabbiani et al, 1971Gabbiani and Badonnel, 1976;Gokel and Hubner, 1977;Ariyan et al, 1978;Grinnell, 1994;Masur et al, 1996;Gabbiani, 2003 Fibroblasts (most widely accepted)…”

Section: Oral Diseasesmentioning

confidence: 99%

Carcinoma‐associated fibroblasts, its implication in head and neck squamous cell carcinoma: a mini review

2013

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The communication between tumor stromal and parenchymal cells provides an insight to tumor progression. One of the main elements of the stroma, a major contributor to the extracellular environment of tumors, is carcinoma-associated fibroblasts. They can originate from either normal fibroblasts in the immediate vicinity of the tumor or from circulating bone marrow-derived mesenchymal stem cells. These myofibroblasts can arise locally from an endothelial-mesenchymal transformation at the invasive edge of the cancer and are physically associated with carcinoma cells, that is, in the development of high-grade malignancies and poor prognosis. These carcinoma-associated fibroblasts feed the epithelial tumor cells in a host-parasite relationship establishing its role in head and neck squamous cell carcinoma progression.

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Wound Contraction and Fibrocontractive Disorders

Cited by 40 publications

References 11 publications

Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors

Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors

Stratus optical coherence tomography study of filtering blebs after primary trabeculectomy with a fornix‐based conjunctival flap

Carcinoma‐associated fibroblasts, its implication in head and neck squamous cell carcinoma: a mini review

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