Wound closure tramadol administration has a short-lived analgesic effect

Abstract

Purpose: To evaluate the effects of tramadol administration at wound closure on postoperative pain and analgesic requirements in patients undergoing laparoscopic cholecystectomy.Methods: In a prospective, randomized, double-blind study 80 patients were allocated into two groups (n = 40 in each) to receive either 200 mg tramadol or placebo iv at the time of wound closure. Postoperatively, all patients received tramadol from a patient-controlled analgesia (PCA) device. Pain, analgesic consumption, vital signs and side effects were recorded postoperatively for 24 hr.Results: Administration of 200 mg tramadol at the time of wound closure was associated with a short-lived (60 min) reduction in pain scores and PCA consumption compared with placebo. Although the time to first request for analgesia after surgery was longer in patients who received tramadol at wound closure, there was no difference between the two groups with respect to pain scores or to the requirements of postoperative analgesia over the next 23 hr. The cumulative PCA consumption of tramadol in 24 hr was 139.4 ± 108 and 102.4 ± 106 mg in the placebo and tramadol groups, respectively (P = 0.06).

Analgesic efficacy of topical tramadol in the control of postoperative pain in children after tonsillectomy

“…Several studies have suggested that tramadol infiltration resulted in a longer analgesic time than parenteral tramadol [11,12]. Our study showed that topical administration of 5% tramadol significantly reduced pain scores 21 h after the operation, and at the next week follow-up compared with the control group.…”

The effect of pain management in laparoscopic cholecystectomy on recovery parameters

“…Although we observed that tramadol can not provide adequate without respiratory depression compared to morphine [7,8].…”

The postoperative analgesic efficacy of intraperitoneal tramadol compared to normal saline or intravenous tramadol in laparoscopic cholecystectomy

“…administration. As in a similar trial in patients undergoing laparoscopic cholecystectomy [20], the analgesic effect of i.v. tramadol was extremely short-lived in our study.…”