Wound Care in Immunobullous Disease

Nadelmann, Emily R.; Czernik, Annette

doi:10.5772/intechopen.71937

Cited by 5 publications

(11 citation statements)

References 56 publications

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“…If the lesion is not treated, the lesion will not heal and will increase in size. 2,8,15 Platelet-rich plasma (PRP) is an endogenous therapeutic technology that has the potential to stimulate and accelerate wound healing. PRP is defined as an autologous biological product derived from the patient's blood where after the centrifugation process, a blood fraction with a higher platelet count is obtained than the circulating blood.…”

Section: A B 2513mentioning

confidence: 99%

“…Several wound treatments play a role in cellular and molecular mechanisms in the wound microenvironment. 2 Platelet-rich plasma (PRP) containing a variety of different growth factors can be used in wound care. It is extracted from whole blood using a series of centrifugation processes and, when activated, releases several antimicrobial microproteins, cytokines, and growth factors.…”

mentioning

confidence: 99%

“…If not treated, the wound will not heal and more and more. 2 This study was to describe autologous PRP therapy in the treatment of excoriated erosional wounds in patients with pemphigus foliaceus.…”

mentioning

confidence: 99%

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Application of Topical Autologous Platelet-Rich Plasma for Treatment of Pemphigus Foliaceus Wounds: A Case Report

et al. 2022

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Background: Pemphigus foliaceus (PF) includes lesions on the skin, generally without involving the mucosa. Wounds in PF arise on the outer layer of the superficial skin, but if left untreated, the wound will not heal and will multiply. Platelet-rich plasma (PRP) containing a variety of different growth factors can be used in wound care. This study was at a time to describe autologous PRP therapy in the treatment of excoriated erosional wounds in patients with pemphigus foliaceus. Case presentation: A woman, 35 years old, married, a housewife living in suburban, comes to the emergency department with complaints of blisters accompanied by pain in the face, body, and back which has been increasing since 1 month ago. Examination of the skin showed palpebral blisters on the eyelids of the left and right eyes. In the anterior and posterior trunk regions, proximal 1/3rd and suprapubic extremities, there are hyperpigmented erythematous macules, multiple, nummular-plaque, discrete, partially confluent, with white to brownish scales, single layer and exfoliative. In the posterior trunk region, Nikolsky's sign was positive. Laboratory evaluation showed an increase in leukocytes and neutrophils. ANA examination showed negative results and anti-ds-DNA 54.91. Management of pemphigus in the form of topical and systemic treatment. Topical management in the form of an open compress with 0.9% NaCl solution, Intrasite gel®, and closed Cutimed sorbact® for erosion and excoriation. Topical PRP was administered on the 7th day of treatment. On the 14th day after treatment with topical PRP, the patient is allowed to go home with the repair of lesions throughout the region. Conclusion: PRP therapy in cases of pemphigus foliaceus is very useful in improving the clinical condition of the patient.

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Section: A B 2513mentioning

confidence: 99%

mentioning

confidence: 99%

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Application of Topical Autologous Platelet-Rich Plasma for Treatment of Pemphigus Foliaceus Wounds: A Case Report

et al. 2022

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“…In addition to the more controversial therapeutic roles that systemic steroids, intravenous immunoglobulins, and plasmapheresis may play, the mainstay clinical TEN management is excellent "burn care," ideally in a burn center with careful attention to pain management, electrolyte balance, topical disinfection, access to burn beds and nonadherent dressings, and prompt treatment of secondary infections. An ophthalmologic consultation is also required because of the risk of corneal erosions and scarring [218].…”

Section: Toxic Epidermal Necrolysis (Ten)mentioning

confidence: 99%

Burn Shock and Resuscitation: Many Priorities, One Goal

Sojka¹,

Krakowski²,

Stawicki³

2020

Clinical Management of Shock - The Science and Art of Physiological Restoration

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Burn injuries come in a wide variety of presentations, depending on the size and depth of the thermal insult, concurrent traumatic or inhalation injury, as well as the associated physiological response of the burn victim. To minimize patient morbidity and reduce mortality, prompt recognition and tailored treatment strategies are critically important. As the percentage of total body surface area (TBSA) burned increases so do the body's physiologic response and the associated complexity of management. Understanding the pathophysiology of burn injury allows the practitioner to optimize and individualize burn patient management-a component of care critical to limiting wound progression and improving outcomes. Burn patient care starts with an accurate and thorough burn patient evaluation conducted in person by an experienced provider. For burns >10-15% TBSA, prompt initiation of fluid resuscitation greatly impacts clinical outcomes. Several formulae have been published to guide crystalloid and/or colloid fluid resuscitation in the setting of burn shock. Other important considerations include ambient temperature control, early enteral nutritional support, vitamin and mineral supplementation, assessment for inhalation injury, glycemic control, early recognition of potential complications of large volume resuscitation, potential need for cardiovascular support, and early wound excision and coverage. Burn patients often require multidisciplinary teams to manage the physical, social, and psychological effects associated with their injury. Dedicated burn centers are the ideal places for meeting the complex needs of each burn patient.

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“…Topical steroids are widely used in treatment of all clinical symptoms of OMD, with a prime aim of reducing pain and inflammation. These are generally applied topically, and include 0.1% triamcinolone acetonide in orabase, 0.05% fluocinolone acetonide, 0.05% clobetasol propionate, or 0.05% halobetasol, A further approach has been intralesional injection of triamcinolone acetonide (20 μg/L) [ 96 ]. They often used as a first line drug with rare side effects and low cost [ 97 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Health, Antimicrobials and Care for Patients With Chronic Oral Diseases – A Review of Knowledge and Treatment Strategies

Ide

Karimova

Setterfield

2022

Front. Oral. Health

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Periodontal and chronic oral mucosal diseases are significant life impacting conditions which may co-exist and synergistically act to cause more severe and widespread oral pathology with enhanced challenges in effective management. Clinicians regularly observe these effects and struggle to effectively manage both problems in many patients. There is limited understanding of many basic and applied scientific elements underpinning potentially shared aetiopathological features and management. Recent developments in translational science provide an opportunity to greater improve knowledge and subsequently care for patients with these problems.

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Wound Care in Immunobullous Disease

Cited by 5 publications

References 56 publications

Application of Topical Autologous Platelet-Rich Plasma for Treatment of Pemphigus Foliaceus Wounds: A Case Report

Application of Topical Autologous Platelet-Rich Plasma for Treatment of Pemphigus Foliaceus Wounds: A Case Report

Burn Shock and Resuscitation: Many Priorities, One Goal

Oral Health, Antimicrobials and Care for Patients With Chronic Oral Diseases – A Review of Knowledge and Treatment Strategies

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