WOSMIP II- Workshop on Signatures of Medical and Industrial Isotope Production

Matthews, Murray A.; Achim, Pascal; Auer, Michael; Bell, R.W.; Bowyer, Ted W.; Braekers, Damien; Bradley, Ed; Briyatmoko, Budi; Berglund, Helena; Camps, Johan; Carranza, Eduardo C; Carty, Fitz; DeCaire, Richard; Deconninck, Benoît; DeGeer, Lars E; Druce, M.; Friese, Judah I.; Hague, R. L.; Hoffman, Ian; Khrustalev, Kirill; Lucas, John C; Mattassi, G; Mattila, Aleski; Nava, E.; Nikkinin, Mika; Papastefanou, C.; Piefer, G.; Ross, Ole; Rotty, Michel; Sabzian, Mohammad; Saey, Paul R. J.; Sameh, A.A.; Safari, Majid; Schöppner, Michael; Siebert, Petra; Unger, Klaus K.; Vargas, A. Llorens

doi:10.2172/1062519

Cited by 8 publications

(11 citation statements)

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“…The radionuclide has excellent physical characteristics for in vivo imaging, and Tc-99 m based imaging is very sensitive and highly quantitative (29). While the research developing positron emitter based imaging agents is vigorous, development of Tc-99 m based imaging agent is still important when increasing global demand for Tc-99 m is considered (30). Moreover, our results demonstrate the advantage of a fluorescence based approach facilitating ex vivo validation of data obtained from in vivo imaging.…”

Section: Mean %Id/g (Sd)mentioning

confidence: 60%

A novel Tc‐99 m and fluorescence labeled peptide as a multimodal imaging agent for targeting angiogenesis in a murine tumor model

Kim

et al. 2016

Contrast Media & Molecular

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The serine-aspartic acid-valine (SDV) peptide binds specifically to integrin α β . In the present study, we successfully developed a TAMRA-GHEG-ECG-SDV peptide labeled with both Tc-99 m and TAMRA to target the integrin α β of tumor cells; furthermore, we evaluated the diagnostic performance of Tc-99 m TAMRA-GHEG-ECG-SDV as a dual-modality imaging agent for tumor of the murine model. TAMRA-GHEG-ECG-SDV was synthesized using Fmoc solid-phase peptide synthesis. Radiolabeling of TAMRA-GHEG-ECG-SDV with Tc-99 m was done using ligand exchange methods. Labeling stability and cytotoxicity studies were performed. Gamma camera imaging, biodistribution and ex vivo imaging studies were performed in murine models with HT-1080 and HT-29 tumors. A tumor tissue slide was prepared and analyzed using confocal microscopy. After radiolabeling procedures with Tc-99 m, the Tc-99 m TAMRA-GHEG-ECG-SDV complexes were prepared in high yield (>99%). In the gamma camera imaging study, a substantial uptake of Tc-99 m TAMRA-GHEG-ECG-SDV into HT-1080 tumor (integrin α β positive) and low uptake of Tc-99 m TAMRA-GHEG-ECG-SDV into HT-29 tumor (integrin α β negative) were demonstrated. A competition study revealed that HT-1080 tumor uptake was effectively blocked by the co-injection of an excess concentration of SDV. Specific uptake of Tc-99 m TAMRA-GHEG-ECG-SDV was confirmed by biodistribution, ex vivo imaging and confocal microscopy studies. Our in vivo and in vitro studies revealed substantial uptake of Tc-99 m TAMRA-GHEG-ECG-SDV in the integrin α β -positive tumor. Tc-99 m TAMRA-GHEG-ECG-SDV could be a good candidate for a dual-modality imaging agent targeting tumor angiogenesis. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Mean %Id/g (Sd)mentioning

confidence: 60%

A novel Tc‐99 m and fluorescence labeled peptide as a multimodal imaging agent for targeting angiogenesis in a murine tumor model

Kim

et al. 2016

Contrast Media & Molecular

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“…The management of these wastes is described in Chapter 5. Xenon plays an important role in monitoring international compliance with the Comprehensive Nuclear-Test-Ban Treaty (CTBT), which prohibits nuclear weapons testing (see, for example, Matthews et al, 2010). This noble gas is mostly nonreactive and has a high yield from uranium fission (see Figure 2.3).…”

Section: Waste Managementmentioning

confidence: 99%

“…Mo-99 suppliers release sufficient Xe-133 from their target processing facilities to be detected by the CTBT monitoring network. The background radioxenon signals from these facilities can potentially interfere with CTBT compliance monitoring (Matthews et al, 2010).…”

Section: Waste Managementmentioning

confidence: 99%

Molybdenum-99 for Medical Imaging

Earth¹

2016

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Technetium-99m, the decay product of molybdenum-99, is the most widely used radionuclide for medical imaging. The images on the cover were produced during a myocardial perfusion imaging (MPI) study using technetium-99m to assess blood flow to heart tissues (courtesy of Henry D. Royal, Washington University School of Medicine). The series of tomographic images at the top are produced during the stress portion (either exercise or pharmacological) of the test and the images at the bottom during the rest portion. The center image (referred to as a bulls-eye image) combines multiple images taken at stress or rest (in this case at rest) to assess myocardial perfusion defects. The black area of the bulls-eye image corresponds to areas of abnormal myocardial perfusion. The patient was diagnosed with a myocardial infarction (i.e., heart attack).

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“…In particular, the fission gases of radioxenon are produced and released into the environment, causing detection in monitoring networks. Because radioxenon is a key indicator of nuclear testing (12,13), these emissions are interfering with treaty monitoring operations connected with the Comprehensive Nuclear-Test-Ban Treaty, the Non-Proliferation Treaty, and considerations of a future Fissile Material Cutoff Treaty (14). Reductions in radioxenon emissions are being sought to minimize or eliminate their impact on nuclear monitoring systems (12).…”

Section: Us Government Development Plansmentioning

confidence: 99%

Diversification in the Supply Chain of ⁹⁹Mo Ensures a Future for ^99mTc

Cutler

Schwarz

2014

J Nucl Med

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The uncertain availability of 99m Tc has become a concern for nuclear medicine departments across the globe. An issue for the United States is that currently it is dependent on a supply of 99m Tc (from 99 Mo) that is derived solely by production outside the United States. Since the United States uses half the world's 99 Mo production, the U.S. 99 Mo supply chain would be greatly enhanced if a producer were located within the United States. The fragility of the old 99 Mo supply chain is being addressed as new facilities are constructed and new processes are developed to produce 99 Mo without highly enriched uranium. The conversion to low-enriched uranium is necessary to minimize the potential misuse of highly enriched uranium in the world for nonpeaceful means. New production facilities, new methods for the production of 99 Mo, and a new generator elution system for the supply of 99m Tc are currently being pursued. The progress made in all these areas will be discussed, as they all highlight the need to embrace diversity to ensure that we have a robust and reliable supply of 99m Tc in the future.

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WOSMIP II- Workshop on Signatures of Medical and Industrial Isotope Production

Cited by 8 publications

References 0 publications

A novel Tc‐99 m and fluorescence labeled peptide as a multimodal imaging agent for targeting angiogenesis in a murine tumor model

A novel Tc‐99 m and fluorescence labeled peptide as a multimodal imaging agent for targeting angiogenesis in a murine tumor model

Molybdenum-99 for Medical Imaging

Diversification in the Supply Chain of ⁹⁹Mo Ensures a Future for ^99mTc

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WOSMIP II- Workshop on Signatures of Medical and Industrial Isotope Production

Cited by 8 publications

References 0 publications

A novel Tc‐99 m and fluorescence labeled peptide as a multimodal imaging agent for targeting angiogenesis in a murine tumor model

A novel Tc‐99 m and fluorescence labeled peptide as a multimodal imaging agent for targeting angiogenesis in a murine tumor model

Molybdenum-99 for Medical Imaging

Diversification in the Supply Chain of 99Mo Ensures a Future for 99mTc

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Product

Resources

About

Diversification in the Supply Chain of ⁹⁹Mo Ensures a Future for ^99mTc