Worth a second look: outcomes of patients with initial finding of regular renal tissue in CT-guided renal tumor biopsies

Sadat-Khonsari, Maryam; Papayannis, Mercedes; Schriefer, P.; Kluth, Luis; Meyer, Christian; Schüttfort, Victor; Regier, Marc; Rink, Michael; Chun, Felix K.‐H.; Fisch, Margit; Becker, Andreas

doi:10.1007/s00345-017-2170-x

Cited by 6 publications

(9 citation statements)

References 13 publications

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“…For example, as a gold standard for ccRCC diagnosis, renal biopsy has a high sensitivity of diagnosis with a low complication rate of <5% [12];however, due to the asymptomatic of ccRCC at an early stage, it cannot be diagnosed at the early days through renal biopsy. What's more, Sadat-Khonsari et al [13] found that patients with suspicious renal masses cannot be precluded from being diagnosed with malignancies; although, with an unsuspicious histology in CTguided renal tumor biopsy and almost 30% of these patients, further diagnostic or therapeutic workup demonstrated a cancer diagnosis. Previous several studies in other cancer types already showed that survivin can also be measured in the serum using a human surviving enzyme-linked immunosorbent assay [14][15][16][17][18], which makes it a noninvasive method for detecting ccRCC.…”

Section: Discussionmentioning

confidence: 99%

The Early Diagnostic and Prognostic Value of BIRC5 in Clear-Cell Renal Cell Carcinoma Based on the Cancer Genome Atlas Data

et al. 2021

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Purpose: The aim of this study was to investigate the role of BIRC5 for early diagnosis and prognosis in clear-cell renal cell carcinoma (ccRCC) by studying the expression of BIRC5 and the correlation between BIRC5 expression and clinicopathological parameters and prognosis in ccRCC. Methods: The BIRC5 expression in ccRCC tissues and normal kidney tissues was measured using the Cancer Genome Atlas database and the Human Protein Atlas database. The correlation between BIRC5 expression and clinicopathological parameters and prognosis in ccRCC was analyzed using UALCAN, the Kaplan-Meier plotter, GEPIA, and SurvExpress. Thirteen-paired ccRCC plasma samples were used to verify the BIRC5 early diagnosis value of ccRCC. Results: The BIRC5 expression is significantly higher in ccRCC than in normal kidney tissues, and is correlated with the clinical stage and pathological grade of ccRCC (p < 0.05). The result of analyzing the relationship between BIRC5 expression and outcomes in ccRCC indicates that a high BIRC5 expression is an independent prognostic factor affecting the overall survival and disease-free survival of ccRCC (p < 0.05). Compared with normal kidney tissues, the immunohistochemical test shows that BIRC5 is significantly upregulated in ccRCC tissues. mRNA expression levels of BIRC5 were significantly higher in the ccRCC plasma than normal (p < 0.05). Conclusions: The high expression of BIRC5 is an important indicator for the prognosis of ccRCC, which makes BIRC5 an effective biomarker for predicting the prognosis of patients in ccRCC. BIRC5 may be a great potential biomarker for early diagnosis of ccRCC.

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Section: Discussionmentioning

confidence: 99%

The Early Diagnostic and Prognostic Value of BIRC5 in Clear-Cell Renal Cell Carcinoma Based on the Cancer Genome Atlas Data

et al. 2021

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“…Obstruction of the renal pedicle, an inevitable method in NSS, greatly reduces intraoperative blood loss and obtains a clear surgical vision. However, the kidney is in an ischemic state after obstruction, and if the blocking time cannot be controlled, it will lead to postoperative renal damage ( 12 ). Currently, laparoscopic surgery has been applied in clinical practice, but LPN requires strict operation skills of the surgeons such as removing tumors, repairing renal pelvis and renal calyx, renal hemostasis, suture techniques in a narrow space under a laparoscope ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of Laparoscopic Partial Nephrectomy and Open Partial Nephrectomy on Outcomes of Clear Cell Renal Cell Carcinoma

Liu

2021

Front. Surg.

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Objective: To analyze the impact of laparoscopic partial nephrectomy (LPN) and open partial nephrectomy (OPN) on outcomes of complex clear cell renal cell carcinoma (ccRCC).Methods: A total of 132 high-complex ccRCC patients with a Radius Exophytic Nearness Anterior Location (R.E.N.A.L) score ≥7 enrolled in our hospital between January 2018 and June 2020 were matched and assigned to an LPN group (given LPN treatment) and an OPN group (given OPN treatment), with 66 cases in each group. Two weeks and 3 months after the operation, the renal indexes, inflammatory factors, basic perioperative conditions, and incidence of complications were compared.Results: Two weeks after the operation, the levels of SCr and CysC were elevated, with higher levels observed in the LPN group (all P < 0.05), and the eGFR levels were reduced, with a lower result in the LPN group. Three months after the operation, the two groups observed decreased levels of SCr and CysC, and an increased level of eGFR; moreover, the decreased SCr and CysC levels were still higher, and the increased eGFR was lower than those before the operation (P < 0.05). The levels of CRP and TNF-α in the two groups increased after the operation, with a lower outcome in the LPN group (P < 0.05). Moreover, the LPN group had less intraoperative blood loss and shorter postoperative length of hospital stay but longer blocking time compared to the OPN group (P < 0.05). Patients in the LPN group were recorded with a lower complication incidence compared with the OPN group (3.03 vs. 15.15%, P < 0.05).Conclusion: Both LPN and OPN enjoy significant efficacy in the treatment of complex ccRCC and effectively protect renal function. Moreover, LPN is a more acceptable option for complex ccRCC due to its numerous benefits in postoperative stress response, complications, recovery. which is worthy of promotion with safety and feasibility.

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“…In addition, second-look interpretations and primary readings have been performed in different environments with different clinical priorities and different levels of expertise. Furthermore, in certain radiological environments, there is an emphasis on the quantity of work produced, which is easier to measure than the quality of interpretation [11]. Another limitation is that the scenario where expert MSK radiologists are present to reevaluate the CTs of MM patients is difficult to propose.…”

Section: Discussionmentioning

confidence: 99%

“…In many centres, consultation and second-opinion interpretation of medical images by subspecialty radiologists are routinely performed [8][9][10][11][12]. Therefore, the purpose of this study is to evaluate the increased detection of focal lesions and other radiological findings of subspecialty second-opinion (SSO) consultations for CT examinations in MM patients undergoing stem cell transplantation on standard computed tomography.…”

Section: Introductionmentioning

confidence: 99%

Subspecialty Second-Opinion in Multiple Myeloma CT: Emphasis on Clinically Significant Lytic Lesions

et al. 2020

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Background and objectives: In order to increase the accuracy of lytic lesion detection in multiple myeloma, a dedicated second-opinion interpretation of medical images performed by subspecialty musculoskeletal radiologists could increase accuracy. Therefore, the purpose of this study is to evaluate the added value (increased accuracy) of subspecialty second-opinion (SSO) consultations for Computed Tomography (CT) examinations in Multiple Myeloma (MM) patients undergoing stem cell transplantation on standard computed tomography with a focus on focal lesion detection. Materials and Methods: Approval from the institutional review board was obtained. This retrospective study included 70 MM consecutive patients (mean age, 62 years ± 11.3 (standard deviation); range, 35–88 years) admitted in the last six years. Pre-transplant total-body CT (reported by general radiologists) was the only inclusion criteria. Each of these CT examinations had a second-opinion interpretation by two experienced subspecialty musculoskeletal (MSK) radiologists (13 years of experience and 6 years of experience, mean: 9.5 years), experts in musculoskeletal radiology and bone image interpretation with a focus on lytic lesions. Results: Per lesion intra- and inter-observer agreement between the two radiologists was calculated with K statistics and the results were good (K = 0.67: Confidence Inteval (CI) 95%: 0.61–0.78). When the initial CT reports were compared with the re-interpretation reports, 46 (65%) of the 70 cases (95% CI: 37–75%) had no discrepancy. There was a discrepancy in detecting a clinically unimportant abnormality in 10/70 (14%) patients (95% CI: 7–25%) unlikely to alter patient care or irrelevant to further clinical management. A discrepancy in interpreting a clinically important abnormality was registered in 14/70 (21%) patients for focal lesions. The mean diameter of focal lesions was: 23 mm (95% CI: 5–57 mm). The mean number of focal lesions per patient was 3.4 (95% CI). Conclusions: subspecialty second-opinion consultations in multiple myeloma CT is more accurate to identify lesions, especially lytic lesions, amenable to influence patients’ care.

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Worth a second look: outcomes of patients with initial finding of regular renal tissue in CT-guided renal tumor biopsies

Abstract: An unsuspicious histology in CT-guided renal tumor biopsy does not preclude patients with suspicious renal masses from being diagnosed with malignancies.

Cited by 6 publications

References 13 publications

The Early Diagnostic and Prognostic Value of BIRC5 in Clear-Cell Renal Cell Carcinoma Based on the Cancer Genome Atlas Data

The Early Diagnostic and Prognostic Value of BIRC5 in Clear-Cell Renal Cell Carcinoma Based on the Cancer Genome Atlas Data

Impact of Laparoscopic Partial Nephrectomy and Open Partial Nephrectomy on Outcomes of Clear Cell Renal Cell Carcinoma

Subspecialty Second-Opinion in Multiple Myeloma CT: Emphasis on Clinically Significant Lytic Lesions

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