Worsening of Health and a Cessation or Reduction in Alcohol Consumption to Special Occasion Drinking Across Three Decades of the Life Course

Fat, Linda Ng; Cable, Noriko; Shelton, Nicola

doi:10.1111/acer.12596

Cited by 36 publications

(37 citation statements)

References 34 publications

(66 reference statements)

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“…Furthermore, we observed that former drinkers had higher levels of cytokines than stable nondrinkers, in keeping with the idea that failing to exclude former drinkers from the group of stable nondrinkers will lead to overestimating the protective effect of moderate drinking 42. This group may consist of former heavy drinkers (including individuals with a history of alcohol use disorders) and those with illnesses that have led to alcohol cessation 60, both of which are likely to be associated with higher levels of inflammation 61, 62, 63. However, it is also worth noting that amongst those with existing illness, alcohol abstinence is generally associated with better long‐term prognosis than continued drinking 64, 65.…”

Section: Discussionsupporting

confidence: 82%

Ten‐year alcohol consumption typologies and trajectories of C‐reactive protein, interleukin‐6 and interleukin‐1 receptor antagonist over the following 12 years: a prospective cohort study

et al. 2016

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BackgroundModerate alcohol consumption is thought to confer cardiometabolic protective effects. Inflammatory pathways are hypothesized to partly underlie this association.ObjectivesThe aim of this study was to examine the association between typologies of alcohol consumption and markers of inflammation, and their rate of change over time.MethodsData were collected from 8209 participants [69% men; mean age, 50 years (SD 6.1)] of the British Whitehall II study. Alcohol consumption typologies were defined using up to three measures during an approximately 10‐year period spanning from 1985 to 1994 as (i) stable nondrinkers, (ii) stable moderate drinkers (referent), (iii) stable heavy drinkers, (iv) nonstable drinkers and (v) former drinkers. C‐reactive protein (CRP), interleukin (IL)‐6 and IL‐1 receptor antagonist (IL‐1 RA) were measured up to three times in the following 12 years.ResultsStable moderate drinkers had lower levels of CRP than stable nondrinkers, stable heavy drinkers, former drinkers and nonstable drinkers, but there were no differences in the rate of change in CRP over time between groups. Stable nondrinkers had higher levels of IL‐6 as did stable heavy drinkers; rates of change in IL‐6 over time were also increased in the latter group. Stable nondrinkers also had higher levels of IL‐1 RA. These associations were robust to adjustment for confounding factors.ConclusionOur novel investigation of 10‐year drinking typologies shows that stable moderate alcohol consumption is associated with a long‐term inflammatory marker profile that is consistent with conferring a reduced risk of developing coronary heart disease.

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Section: Discussionsupporting

confidence: 82%

Ten‐year alcohol consumption typologies and trajectories of C‐reactive protein, interleukin‐6 and interleukin‐1 receptor antagonist over the following 12 years: a prospective cohort study

et al. 2016

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“…While previous research has demonstrated that sociodemographic factors are associated with drinking cessation (Dawson et al., ; Ng Fat et al., ; Park et al., ; Pringle et al., ), the relative impact of specific health conditions is less clear. Our results are consistent with prospective studies showing that drinking cessation (or reduction) is associated with cardiovascular disease (Dawson et al., ; Wannamethee and Shaper, ) and also with 1 study that reported increased odds of drinking cessation in relation to commencing certain medications (Pringle et al., ).…”

Section: Discussionmentioning

confidence: 97%

“…These findings are supported by evidence from interventional studies indicating that alcohol consumption is associated with improvement in some cardiovascular biomarkers (Brien et al., ). Even if causal, it is still possible that the level of protection afforded by alcohol consumption may be overestimated due to persons decreasing their alcohol consumption to occasional drinking in response to illness rather than quitting (Ng Fat et al., ).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that certain sociodemographic characteristics, including sex, age, race, level of education, family income, urban residence, marital status, and retirement, are associated with drinking cessation (Dawson et al., ; Ng Fat et al., ; Park et al., ; Pringle et al., ). All analyses were adjusted for sociodemographic characteristics at baseline; missing indicators were included for incomplete data: sex, age (45 to 54, 55 to 64, 65 to 74, 75 to 84, ≥85 years), highest level of education attained (no school certificate or other qualifications/school or intermediate certificate/higher school or leaving certificate/trade or apprenticeship/certificate or diploma/university degree or higher), annual pretax household income (<$30,000/$30,000 to $69,999/≥$70,000 Australian dollars), health insurance status (none/healthcare concession card/Department of Veterans’ Affairs white or gold card/private health insurance without extras/private health insurance with extras), partner status (married or living with partner/not), country of birth (Australia/Canada, Ireland, New Zealand, the United Kingdom, or the United States/other), and remoteness of residence.…”

Section: Methodsmentioning

confidence: 99%

“…There are few large prospective studies that have quantified the relationship between health conditions and drinking cessation. Health conditions previously reported to be associated with drinking cessation, or changes in drinking volume, have included poor/declining self‐rated overall health as well as chronic disease, mental health conditions, medications, and hospitalization (Brennan et al., ; Dawson et al., ; Glass et al., ; Holdsworth et al., ; Ng Fat et al., ; Ortola et al., ; Park et al., ; Platt et al., ; Pringle et al., ; Wannamethee and Shaper, ). Overall, these studies have differed in methodology and study size (with n s ranging from 571 to 14,885; some were possibly underpowered), and have mostly examined a small number of illnesses.…”

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confidence: 99%

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A Prospective Study of Health Conditions Related to Alcohol Consumption Cessation Among 97,852 Drinkers Aged 45 and Over in Australia

Sarich

Canfell

Banks

et al. 2019

Alcoholism Clin & Exp Res

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Background: Evidence suggests that people who develop serious health conditions are likely to cease drinking alcohol (sometimes known as "sick-quitters"). We quantified the likelihood of quitting drinking in relation to the onset of a variety of health conditions.Methods: Odds ratios (ORs) and 95% confidence intervals (CIs) of ceasing alcohol consumption after diagnosis of 28 health conditions and 4 general indicators of health were derived from logistic regression among 97,852 drinkers aged ≥ 45 years between baseline (2006 to 2009) and median 5.3 years of follow-up in the New South Wales 45 and Up Study. Incident health conditions at followup were self-reported.Results: At follow-up, 9.6% (n = 9,438) of drinkers had ceased drinking. Drinking cessation was significantly associated with 24 of 32 health conditions examined: 15.4% of participants with newly diagnosed diabetes quit drinking (OR for quitting vs. continuing 1.77, 95% CI: 1.60 to 1.96), 16.

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Association Between Daily Alcohol Intake and Risk of All-Cause Mortality

et al. 2023

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ImportanceA previous meta-analysis of the association between alcohol use and all-cause mortality found no statistically significant reductions in mortality risk at low levels of consumption compared with lifetime nondrinkers. However, the risk estimates may have been affected by the number and quality of studies then available, especially those for women and younger cohorts.ObjectiveTo investigate the association between alcohol use and all-cause mortality, and how sources of bias may change results.Data SourcesA systematic search of PubMed and Web of Science was performed to identify studies published between January 1980 and July 2021.Study SelectionCohort studies were identified by systematic review to facilitate comparisons of studies with and without some degree of controls for biases affecting distinctions between abstainers and drinkers. The review identified 107 studies of alcohol use and all-cause mortality published from 1980 to July 2021.Data Extraction and SynthesisMixed linear regression models were used to model relative risks, first pooled for all studies and then stratified by cohort median age (&lt;56 vs ≥56 years) and sex (male vs female). Data were analyzed from September 2021 to August 2022.Main Outcomes and MeasuresRelative risk estimates for the association between mean daily alcohol intake and all-cause mortality.ResultsThere were 724 risk estimates of all-cause mortality due to alcohol intake from the 107 cohort studies (4 838 825 participants and 425 564 deaths available) for the analysis. In models adjusting for potential confounding effects of sampling variation, former drinker bias, and other prespecified study-level quality criteria, the meta-analysis of all 107 included studies found no significantly reduced risk of all-cause mortality among occasional (&gt;0 to &lt;1.3 g of ethanol per day; relative risk [RR], 0.96; 95% CI, 0.86-1.06; P = .41) or low-volume drinkers (1.3-24.0 g per day; RR, 0.93; P = .07) compared with lifetime nondrinkers. In the fully adjusted model, there was a nonsignificantly increased risk of all-cause mortality among drinkers who drank 25 to 44 g per day (RR, 1.05; P = .28) and significantly increased risk for drinkers who drank 45 to 64 and 65 or more grams per day (RR, 1.19 and 1.35; P &lt; .001). There were significantly larger risks of mortality among female drinkers compared with female lifetime nondrinkers (RR, 1.22; P = .03).Conclusions and RelevanceIn this updated systematic review and meta-analysis, daily low or moderate alcohol intake was not significantly associated with all-cause mortality risk, while increased risk was evident at higher consumption levels, starting at lower levels for women than men.

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Worsening of Health and a Cessation or Reduction in Alcohol Consumption to Special Occasion Drinking Across Three Decades of the Life Course

Cited by 36 publications

References 34 publications

Ten‐year alcohol consumption typologies and trajectories of C‐reactive protein, interleukin‐6 and interleukin‐1 receptor antagonist over the following 12 years: a prospective cohort study

Ten‐year alcohol consumption typologies and trajectories of C‐reactive protein, interleukin‐6 and interleukin‐1 receptor antagonist over the following 12 years: a prospective cohort study

A Prospective Study of Health Conditions Related to Alcohol Consumption Cessation Among 97,852 Drinkers Aged 45 and Over in Australia

Association Between Daily Alcohol Intake and Risk of All-Cause Mortality

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