Worldwide drinking water occurrence and levels of newly-identified perfluoroalkyl and polyfluoroalkyl substances

Kaboré, Hermann A.; Duy, Sung Vo; Munoz, Gabriel; Meite, Ladji; Desrosiers, Mélanie; Liu, Jinxia; Sory, Traore Karim; Sauvé, Sébastien

doi:10.1016/j.scitotenv.2017.10.210

Cited by 229 publications

(136 citation statements)

References 71 publications

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“…The neutral target compounds were not separately measured in the current study, and the proportion of measurable PFAS to EOF could therefore not be determine. Several shorter chain homologues of neutral sulfonamides (perfluorohexanesulfonamide and perfluorobutanesulfonamide including their respective methyl-substituted sulfonamides) were recently detected in the environment , Kabore et al, 2018, and these compounds should be measured in future studies. Relatively lower contribution (<10%) of measurable PFASs to EOF were observed in the anionic fraction of the water samples in the present study.…”

Section: Eofmentioning

confidence: 99%

PFASs in the Nordic environment

Kärrman¹,

Wang²,

Kallenborn³

et al. 2019

TemaNord

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Section: Eofmentioning

confidence: 99%

PFASs in the Nordic environment

Kärrman¹,

Wang²,

Kallenborn³

et al. 2019

TemaNord

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“…In their recent comprehensive paper on worldwide occurrence and levels of newly-identified perfluoroalkyl and polyfluoroalkyl substances in drinking water, Kaboré et al (2018) screened, in total, 29 target and 104 suspect-target PFASs in drinking water samples (n = 97) from Canada and other countries (Burkina Faso, Chile, Ivory Coast, France, Japan, Mexico, Norway, and the USA) in 2015-2016. Out of the 29 PFASs quantitatively analyzed, perfluorocarboxylates (PFCAs: C4/14), perfluoroalkane sulfonates (PFSAs: C4, C6, C8), and perfluoroalkyl acid precursors (e.g., 5:3 fluorotelomer carboxylate (5:3 FTCA)) were recurrently detected in drinking water samples in concentrations up to 39 ng/l.…”

Section: Per-and Polyfluoroalkyl Substances (Pfas)mentioning

confidence: 99%

Occurrence of chemicals with known or suspected endocrine disrupting activity in drinking water, groundwater and surface water, Austria 2017/2018

Brueller

Inreiter

Boegl

et al. 2018

Die Bodenkultur: Journal of Land Management, Food and Environment

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Summary Endocrine disrupting chemicals (EDCs) can cause adverse effects in individuals and their offspring. In 2017 and 2018, we performed a survey on representative samples of Austrian drinking water (n = 20), groundwater (n = 22), and surface water (n = 12), the latter including bathing water (n = 5) and rivers (n = 7). We analyzed 54 samples for 28 parameters, including estrogens, polybrominated diphenylethers (PBDEs), phthalates, perfluoroalkyl substances, alkylphenols, bisphenol A and triclosan, correlating to 1512 measurements. In 39 of the 54 samples (72.2%), at least one endocrine disrupting or potentially disrupting chemical was found at or above the limit of quantification. None of the samples yielded estrogens or triclosan in detectable levels. Bisphenol A (BPA) was detected in 4 (20.0%) samples of drinking water, in 1 (4.5%) groundwater sample, and in 1 (20%) bathing water sample, with a maximum concentration of 0.021 μg/l found in one drinking water. Two drinking water samples yielded BPA in concentrations above the limit value of 0.01 μg/l, recently proposed by the European Commission for drinking water. Therefore, the ultimate public health goal must be to further reduce and restrict the production of EDCs and therewith decrease and eventually eliminate the contamination of drinking water resources.

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“…Alternative chemistries that retain the long-chain character, such as ADONA, were engineered with ether linkages and sites of hydrogenation in efforts to reduce biological half-lives (Fromme et al 2017). Replacement PFAS are therefore increasingly detected in the environment, including in surface water (De Silva et al 2011;McCord et al 2018;Pan et al 2018;Strynar et al 2015;Wang et al 2016) and drinking water (Kaboré et al 2018;McCord et al 2018). Environmental screening efforts have also identified relevant exposures to PFAS by-products, such as sulfonated fluorovinyl ethers (i.e., PFESA compounds), that are not strictly chemicals of commerce (McCord et al 2018;Strynar et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

Gaballah

Swank

Sobus

et al. 2020

Environ Health Perspect

251

149

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BACKGROUND: Per-and polyfluoroalkyl substances (PFAS) are a diverse class of industrial chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is associated with developmental toxicity, prompting their replacement with short-chain and fluoroether compounds. There is growing public concern over the safety of replacement PFAS. OBJECTIVE: We aimed to group PFAS based on shared toxicity phenotypes. METHODS: Zebrafish were developmentally exposed to 4,8-dioxa-3H-perfluorononanoate (ADONA), perfluoro-2-propoxypropanoic acid (GenX Free Acid), perfluoro-3,6-dioxa-4-methyl-7-octene-1-sulfonic acid (PFESA1), perfluorohexanesulfonic acid (PFHxS), perfluorohexanoic acid (PFHxA), perfluoro-n-octanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), or 0.4% dimethyl sulfoxide (DMSO) daily from 0-5 d post fertilization (dpf). At 6 dpf, developmental toxicity and developmental neurotoxicity assays were performed, and targeted analytical chemistry was used to measure media and tissue doses. To test whether aliphatic sulfonic acid PFAS cause the same toxicity phenotypes, perfluorobutanesulfonic acid (PFBS; 4-carbon), perfluoropentanesulfonic acid (PFPeS; 5-carbon), PFHxS (6-carbon), perfluoroheptanesulfonic acid (PFHpS; 7-carbon), and PFOS (8-carbon) were evaluated. RESULTS: PFHxS or PFOS exposure caused failed swim bladder inflation, abnormal ventroflexion of the tail, and hyperactivity at nonteratogenic concentrations. Exposure to PFHxA resulted in a unique hyperactivity signature. ADONA, PFESA1, or PFOA exposure resulted in detectable levels of parent compound in larval tissue but yielded negative toxicity results. GenX was unstable in DMSO, but stable and negative for toxicity when diluted in deionized water. Exposure to PFPeS, PFHxS, PFHpS, or PFOS resulted in a shared toxicity phenotype characterized by body axis and swim bladder defects and hyperactivity. CONCLUSIONS: All emerging fluoroether PFAS tested were negative for evaluated outcomes. Two unique toxicity signatures were identified arising from structurally dissimilar PFAS. Among sulfonic acid aliphatic PFAS, chemical potencies were correlated with increasing carbon chain length for developmental neurotoxicity, but not developmental toxicity. This study identified relationships between chemical structures and in vivo phenotypes that may arise from shared mechanisms of PFAS toxicity. These data suggest that developmental neurotoxicity is an important end point to consider for this class of widely occurring environmental chemicals.

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Worldwide drinking water occurrence and levels of newly-identified perfluoroalkyl and polyfluoroalkyl substances

Cited by 229 publications

References 71 publications

PFASs in the Nordic environment

PFASs in the Nordic environment

Occurrence of chemicals with known or suspected endocrine disrupting activity in drinking water, groundwater and surface water, Austria 2017/2018

Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

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