Worldwide access to treatment for end-stage kidney disease: a systematic review

Liyanage, Thaminda; Ninomiya, Toshiharu; Jha, Vivekanand; Neal, Bruce; Patrice, Halle Marie; Okpechi, Ikechi G.; Zhao, Ming; Lv, Jicheng; Garg, Amit X.; Knight, John; Rodgers, Anthony; Gallagher, Martin; Kotwal, Sradha; Cass, Alan; Perkovic, Vlado

doi:10.1016/s0140-6736(14)61601-9

Cited by 1,756 publications

(1,581 citation statements)

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“…The equality of access to RRT for women and girls is of concern because, in many societies, they are disadvantaged by discrimination rooted in sociocultural factors. There is a paucity of information about sex differences in RRT, but in multiple countries, men are reported to be more likely than women to receive dialysis [11,12]. Women are more likely to donate kidneys for transplantation than to receive them, as reported from multiple countries; they are less likely to be registered on transplant waiting lists, and wait longer from dialysis initiation to listing.…”

Section: Renal Replacement Therapies (Rrts)mentioning

confidence: 99%

Women and kidney disease: reflections on World Kidney Day 2018

Piccoli

Alrukhaimi

Liu

et al. 2018

Kidney International

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Chronic kidney disease affects 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health, and specifically their kidney health, to the community and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women, so that we may apply those learnings more broadly. Girls and women, who make up 50% of the world's population, are important contributors to society as a whole and to their families. Gender differences continue to exist around the world in access to education, medical care and participation in clinical studies. Pregnancy is a unique state for women, offering an opportunity for diagnosis of kidney disease, and also a state where acute and chronic kidney diseases may manifest, and which may impact future generations with respect to kidney health. There are various autoimmune and other conditions that are more likely to impact women with profound consequences for child bearing, and for the fetus. Women have different complications on dialysis than men, and are more likely to be donors than recipients of kidney transplants. In this editorial, we focus on what we do and do not know about women, kidney health and kidney disease, and what we might learn in the future to improve outcomes worldwide.

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Section: Renal Replacement Therapies (Rrts)mentioning

confidence: 99%

Women and kidney disease: reflections on World Kidney Day 2018

Piccoli

Alrukhaimi

Liu

et al. 2018

Kidney International

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“…In this issue of JASN, Thomas et al 1 2 During the same period, global incidence more than doubled from 44 to 93 per 1 million population, a worldwide incidence of nearly 700,000 new patients per year.…”

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confidence: 99%

“…Indeed, a recent study reports that, using a conservative analytic approach, perhaps 2.3 million individuals requiring RRT died prematurely, because they could not access it; a more liberal approach put the total at a truly daunting estimate of 7.1 million premature deaths. 2 This "RRT gap" can, therefore, be conceived of as the true present need for maintenance dialysis or kidney transplantation, even before considering future growth of the population (expected to reach 9.6 billion in 2050 3 ), the aging of the population, or the increases in rates of diabetes and hypertension that are occurring as the world's population urbanizes and becomes more affluent. 4 An important distinction must be made between countries that provide universal dialysis access and those that do not, a distinction without which the understanding of dialysis growth is incomplete.…”

mentioning

confidence: 99%

“…In Asia alone, 1.9 million people may need RRT but do not receive it according to a conservative estimate; even with a large persistent gap, the number of patients who do receive dialysis seems likely to double from 1.0 to 2.0 million between 2010 and 2030. 2 Because the factors driving the growth of ESRD are not fully understood, it is possible that the rapid economic growth characterizing India, China, and other Asian nations may mean that projections of ESRD growth are underestimates.…”

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confidence: 99%

“…Early studies focused on the gene expression of specific molecules of interest and were greatly facilitated by the development of ultrasensitive reverse transcription polymerase chain reaction. 2 As transcriptional profiling techniques matured, more genome-wide approaches could be deployed on microdissected tissue. The landmark study from Chabardès-Garonne et al used serial analysis of gene expression (SAGE) to define transcript maps from the main nephron subunits.…”

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confidence: 99%

See 2 more Smart Citations

Meeting the World’s Need for Maintenance Dialysis

Wetmore

Collins

2015

Journal of the American Society of Nephrology

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Evaluation of Serum Glucose and Kidney Disease Progression Among Patients With Diabetes

Jung

2021

JAMA Netw Open

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IMPORTANCE The appropriate target of glycemic control in diabetic kidney disease is unclear. OBJECTIVE To investigate optimal on-treatment glycemic levels associated with slowing of diabetic kidney disease progression. DESIGN, SETTING, AND PARTICIPANTS This retrospective cohort study was conducted using nationwide Korean cohorts from the National Health Information Database from 2005 to 2019. Included individuals were adults with diabetes using antihyperglycemic agents with and without chronic kidney disease (CKD) identified from participants aged 40 to 74 years in a nationwide health screening survey conducted from 2009 to 2010. Data were analyzed from October 2020 through March 2021. EXPOSURE On-treatment fasting blood glucose (FBG) level. MAIN OUTCOMES AND MEASURES The primary outcome was a composite of doubling of serum creatinine, end-stage kidney disease, or death from CKD. RESULTS Among 183 049 adults with diabetes using antihyperglycemic agents (mean [SD] age, 61.7 [8.4] years; 99 110 [54.1%] men), there were 131 401 individuals with dipstick albuminuria or an estimated glomerular filtration rate (eGFR) of 15 to 59 mL/min/1.73 m 2 (mean [SD] age, 62.4 [8.3] years; 71 280 [54.2%] men) and 51 648 individuals with no CKD (mean [SD] age, 59.6 [8.4] years;27 830 [53.9%] men). During 9 years of follow-up, the primary outcome occurred among 13 802 individuals with CKD (10.5%) and 1421 individuals with no CKD (2.8%). On-treatment FBG level had a J-shaped hazard ratio (HR) curve for the primary outcome. Among patients with albuminuria, FBG levels of 126 mg/dL to less than 140 mg/dL (HR, 0.87; 95% CI, 0.81-0.94) and 140 mg/dL to less than 160 mg/dL (HR, 0.90; 95% CI, 0.84-0.96) were associated with decreased risk and levels of 160 mg/dL to less than 180 mg/dL were associated with increased risk (HR, 1.10; 95% CI, 1.03-1.18) compared with FBG levels of 110 mg/dL to less than 126 mg/dL. Among patients with decreased eGFR, FBG levels of 80 mg/dL to less than 100 mg/dL (HR, 1.30; 95% CI, 1.20-1.42) and levels of 160 mg/dL to less than 180 mg/dL (HR, 1.13; 95% CI, 1.04-1.23) were associated with increased risk of the primary outcome compared with FBG levels of 110 mg/dL to less than 126 mg/dL. Among patients with no CKD, FBG levels of 80 mg/dL to less than 100 mg/dL (HR, 1.29; 95% CI, 1.01-1.65) and levels of 126 mg/dL to less than 140 mg/dL (HR, 1.23; 95% CI, 1.03-1.47) were associated with increased risk compared with FBG levels of 110 mg/dL to less than 126 mg/dL. Among patients with no albuminuria at baseline, FBG levels of 140 mg/dL to less than 160 mg/dL (HR, 1.14; 95% CI, 1.09-1.20) were associated with increased risk of new-onset albuminuria, while levels of 100 mg/dL to less than 110 mg/dL were not associated with increased risk compared with FBG levels of 110 mg/dL to less than 126 mg/dL. For all-cause mortality, while FBG levels of 160 mg/dL to less than 180 mg/dL (HR, 1.20; 95% CI, 1.12-1.28) were associated with increased risk among patients with albuminuria, FBG (continued) Key Points Question What is the ...

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Worldwide access to treatment for end-stage kidney disease: a systematic review

Cited by 1,756 publications

References 23 publications

Women and kidney disease: reflections on World Kidney Day 2018

Women and kidney disease: reflections on World Kidney Day 2018

Meeting the World’s Need for Maintenance Dialysis

Evaluation of Serum Glucose and Kidney Disease Progression Among Patients With Diabetes

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