World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment

Villa, Alessandro; Wolff, Ändy; Aframian, Doron J.; Vissink, Arjan; Ekström, Jørgen; Proctor, Gordon; McGowan, Richard; Narayana, Nagamani; Aliko, Ardita; Sia, Ying Wai; Joshi, Revan Kumar; Jensen, Siri Beier; Kerr, Alexander Ross; Dawes, C.; Pedersen, Anne Marie Lynge

doi:10.1007/s00784-015-1488-2

Cited by 88 publications

(81 citation statements)

References 133 publications

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“…Drugs that induce gingival overgrowth also appear to increase risk of periodontal diseases (certainty moderate) (Heasman & Hughes 2014, Villa et al 2015.…”

Section: Medicationsmentioning

confidence: 99%

Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases

Chapple

Bouchard

Cagetti

et al. 2017

J Clinic Periodontology

351

369

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Periodontal diseases and dental caries are the most common diseases of humans and the main cause of tooth loss. Both diseases can lead to nutritional compromise and negative impacts upon self‐esteem and quality of life. As complex chronic diseases, they share common risk factors, such as a requirement for a pathogenic plaque biofilm, yet they exhibit distinct pathophysiologies. Multiple exposures contribute to their causal pathways, and susceptibility involves risk factors that are inherited (e.g. genetic variants), and those that are acquired (e.g. socio‐economic factors, biofilm load or composition, smoking, carbohydrate intake). Identification of these factors is crucial in the prevention of both diseases as well as in their management. Aim To systematically appraise the scientific literature to identify potential risk factors for caries and periodontal diseases. Methods One systematic review (genetic risk factors), one narrative review (role of diet and nutrition) and reference documentation for modifiable acquired risk factors common to both disease groups, formed the basis of the report. Results & Conclusions There is moderately strong evidence for a genetic contribution to periodontal diseases and caries susceptibility, with an attributable risk estimated to be up to 50%. The genetics literature for periodontal disease is more substantial than for caries and genes associated with chronic periodontitis are the vitamin D receptor (VDR), Fc gamma receptor IIA (Fc‐γRIIA) and Interleukin 10 (IL10) genes. For caries, genes involved in enamel formation (AMELX, AMBN, ENAM, TUFT, MMP20, and KLK4), salivary characteristics (AQP5), immune regulation and dietary preferences had the largest impact. No common genetic variants were found. Fermentable carbohydrates (sugars and starches) were the most relevant common dietary risk factor for both diseases, but associated mechanisms differed. In caries, the fermentation process leads to acid production and the generation of biofilm components such as Glucans. In periodontitis, glycaemia drives oxidative stress and advanced glycation end‐products may also trigger a hyper inflammatory state. Micronutrient deficiencies, such as for vitamin C, vitamin D or vitamin B12, may be related to the onset and progression of both diseases. Functional foods or probiotics could be helpful in caries prevention and periodontal disease management, although evidence is limited and biological mechanisms not fully elucidated. Hyposalivation, rheumatoid arthritis, smoking/tobacco use, undiagnosed or sub‐optimally controlled diabetes and obesity are common acquired risk factors for both caries and periodontal diseases.

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“…Drugs that induce gingival overgrowth also appear to increase risk of periodontal diseases (certainty moderate) (Heasman & Hughes 2014, Villa et al 2015.…”

Section: Medicationsmentioning

confidence: 99%

Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases

Chapple

Bouchard

Cagetti

et al. 2017

J Clinic Periodontology

351

369

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“…Swallowing disorders (dysphagia) and dry mouth (xerostomia, salivary gland hypofunction) are the most prevalent oral processing conditions encountered by aging adults. Xerostomia is a subjective sensation related to mucosal dehydration and reduced oral lubrication, which is not necessarily linked to salivary gland hypofunction (Liu, Dion, Jurasic, Gibson, & Jones, 2012;Nagler & Hershkovich, 2005;Navazesh, Christensen, & Brightman, 1992;Pajukoski, Meurman, Halonen, & Sulkava, 2001;Villa et al, 2015). In patients suffering from xerostomia, secreted saliva lacks the ability to continuously wet the whole oral cavity uniformly (Närhi, 1994).…”

mentioning

confidence: 99%

Aging‐related changes in quantity and quality of saliva: Where do we stand in our understanding?

Laguna

Sarkar

2018

Journal of Texture Studies

159

137

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The population has undergone a fundamental change in its age structure globally, with a rapid increase in elderly population. Innovation of tailored foods is still in its early stage to satisfy the needs of growing aging population. One of the biggest challenges in such food product development is lack of adequate understanding and characterization of endogenous factors, that is, age-related changes in saliva, which may influence oral processing of food and subsequently nutrient intake. Aging affects the salivary glands and alters quantity (flow rate) and quality (e.g., ion and protein composition, rheology, tribology) of saliva. Thus, older adults may suffer from dry mouth, taste aberration, and poor oral hygiene, greatly affecting their quality of life. This review provides insights into how age versus other health conditions influence salivary properties. Understanding of age-dependent changes in salivary rheology and tribology will be of paramount importance to optimize food for elderly population.

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“…Today, older adults retain most of their teeth for life, often with technically complex replacements for lost teeth that place great demands on their ability to perform daily oral hygiene . More risk factors, such as medication‐induced dry mouth, dietary changes, and impaired oral and upper motor skills, often result in an inadequate ability to manage oral hygiene, which, in turn, may be reflected in impaired oral health, well‐being and quality of life . Effective and adapted preventive measures, largely involving oral hygiene, are therefore necessary …”

Section: Introductionmentioning

confidence: 99%

Development of an instrument to assess oral hygiene ability in older adults: The oral hygiene ability instrument

et al. 2019

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Objectives To describe the development process of an instrument to assess the ability to manage daily oral hygiene and the cause of impaired oral hygiene. The instrument is initially aimed for use by the dental team in the ageing population. Background Oral hygiene is an important component of oral health. Inability to manage oral hygiene combined with other risk factors often results in poor oral health and impaired quality of life. Methods A guideline for instrument development was used during the construction of the instrument. The method included three phases: I. planning: the purpose and target group of the instrument were determined, and a literature review and qualitative focus‐group study were conducted; II. construction: objectives were formulated, and a pool of items was built; and III. evaluation and validation, which included two pilot studies, interviews, item analyses and revision of the instrument. Results The planning and construction phases resulted in an instrument with 47 items comprising three parts: (a) interview, (b) clinical examination and (c) observation of activities of daily living (oral hygiene). After two pilot studies, the instrument was found to have good content validity. Analyses of qualitative and quantitative data resulted in a reduction in the number of items to 33. Conclusion OHAI can be a valuable tool as a preventive method to identify older adults at risk of impaired oral health. However, the instrument needs further evaluation before wider use.

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World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment

Abstract: MISGD remains a major burden for the population. This systematic review provides a contemporary in-depth description of the diagnosis and treatment of MISGD.

Cited by 88 publications

References 133 publications

Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases

Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases

Aging‐related changes in quantity and quality of saliva: Where do we stand in our understanding?

Development of an instrument to assess oral hygiene ability in older adults: The oral hygiene ability instrument

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