World Health Organization 4th edition of head and neck tumor classification: insight into the consequential modifications

Cutaneous Angiomyolipoma of the Nose

“…Cutaneous AML an uncommon extra renal form of AML, was first described by Fitzopatrick et al [7] in 1990 where eight cases of cutaneous AML was reported under the name angiolipoleiomyoma [7]. AML was subsequently classified as hamartomatous tumour which arises from perivascular epithelioid cells [8].…”

Completion surgery after extracapsular dissection of low‐grade parotid gland malignant tumors

“…The group is large enough to contain less aggressive lesions, such as the “low‐grade” (but still by no means innocent) acinic cell carcinoma with a 20‐year disease‐specific survival of 93.5% at stage I on the one hand and highly aggressive histologic subtypes, such as the salivary duct carcinoma (“the big villain”), with a 5‐year overall survival of 43% and most of the patients dying within 3 years from the time of diagnosis on the other hand . Retrospective studies on salivary gland malignancies are being further confused by the significant changes from one WHO classification to another (“an evolving art”), with the number of subtypes having been notably reduced in 2017 for the first time since 1972 (in comparison to the last classification system of 2005) . The possibility of retrospectively changing the diagnosis by using molecular genetic methods (eg, fluorescence in situ hybridization) should not be overlooked: the retrospective change in diagnosis, after molecular identification of the ETV6‐NTRK‐3, from an acinic cell carcinoma to a mammary analogue secretory carcinoma with a less favorable prognosis is one prominent example .…”

Multimodal widefield fluorescence imaging with nonlinear optical microscopy workflow for noninvasive oral epithelial neoplasia detection: a preclinical study

“…5 OSCCs, primarily oral epithelial dysplasia (OED), have potential to develop from neoplasia, an abnormal growth of the epithelium due to a malignant or a benign precancerous lesion. 6,7 With grade of OEDs remaining the key factor to assess risk for transformation of such lesions, there have been increased efforts to detect OEDs harbored in lesions to aid in clinical decisions. 8,9 There remains a need for methods that more effectively support detection efforts.…”