Working memory profiles of patients with multiple sclerosis: Where does the impairment lie?

Kouvatsou, Zoe; Masoura, Elvira; Kiosseoglou, Grigoris; Kimiskidis, Vasilios Κ.

doi:10.1080/13803395.2019.1626805

Cited by 11 publications

(12 citation statements)

References 72 publications

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“…With regard to the nature of WM impairment, we estimated the degree of impairment in each of the four WM components ( Kouvatsou et al, 2019 ). Results revealed that WM components are differentially affected in patients with MS and, more precisely, impairment in the episodic buffer was found to be more profound than impairment in the phonological loop, central executive and the spatial subcomponent of visuospatial sketchpad.…”

Section: Discussionmentioning

confidence: 99%

“…However, these studies have selectively examined only some WM components, while a thorough evaluation of all WM components in an adequate sample of MS patients, was not available yet. Thus, in Kouvatsou et al (2019) , we attempted to investigate in detail the level of impairment in all WM components in a group of patients with MS, using sensitive tasks and assessments for each WM’s component.…”

Section: Introductionmentioning

confidence: 99%

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Working Memory Deficits in Multiple Sclerosis: An Overview of the Findings

2022

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Although working memory (WM) and information processing speed (IPS) impairments in multiple sclerosis (MS) have been widely investigated, several questions, regarding the nature of these impairments and their relationship, remain unclear. The aim of this short communication article is to present an overview of our recent research findings regarding (a) the characteristics of WM impairment in MS patients and, more precisely, the degree of impairment observed in each WM’s component, i.e., phonological loop, visuospatial sketchpad, central executive, and episodic buffer and (b) the relationship between IPS and each of the four WM components, in an attempt to expand the existing rather narrow understanding of the interconnection between reduced IPS and WM impairment. Two studies of our research team are presented here and their findings are briefly discussed, highlighting the importance of further research on a specific component, namely the episodic buffer component among MS patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Working Memory Deficits in Multiple Sclerosis: An Overview of the Findings

2022

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“…This seems to be indirectly corroborated by the high prevalence of motor imagery impairments in other neurological populations (e.g., Parkinson’s disease and stroke) with similar disruptions of neural networks [ 31 ]. Additionally, impairments of working memory, which are highly prevalent in MS [ 32 , 33 ], have also been proposed as a putative mechanism responsible for the temporal error between imagined and actual walking (i.e., mental chronometry) [ 34 ]. Importantly, some researchers have postulated that failure to update internal models may lead to over-optimistic predictions of planned actions in populations at risk of cognitive dysfunction [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Motor Imagery of Walking in People Living with and without Multiple Sclerosis: A Cross-Sectional Comparison of Mental Chronometry

2021

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Motor imagery represents the ability to simulate anticipated movements mentally prior to their actual execution and has been proposed as a tool to assess both individuals’ perception of task difficulty as well as their perception of their own abilities. People with multiple sclerosis (pwMS) often present with motor and cognitive dysfunction, which may negatively affect motor imagery. In this cross-sectional study, we explored differences in motor imagery of walking performance between pwMS (n = 20, age = 57.1 (SD = 8.6) years, 55% female) and age- and sex-matched healthy controls (n = 20, age = 58.1 (SD = 7.0) years, 60% female). Participants underwent mental chronometry assessments, a subset of motor imagery, which evaluated the difference between imagined and actual walking times across four walking tasks of increasing difficulty (i.e., large/narrow-width walkway with/without obstacles). Raw and absolute mental chronometry (A-MC) measures were recorded in single- (ST) and dual-task (DT) conditions. In ST conditions, pwMS had higher A-MC scores across all walking conditions (p ≤ 0.031, η2 ≥ 0.119), indicating lower motor imagery ability compared to healthy controls. During DT, all participants tended to underestimate their walking ability (3.38 ± 6.72 to 5.63 ± 9.17 s). However, after physical practice, pwMS were less able to adjust their imagined walking performance compared to healthy controls. In pwMS, A-MC scores were correlated with measures of balance confidence (ρ = −0.629, p < 0.01) and the self-reported expanded disability status scale (ρ = 0.747, p < 0.01). While the current study revealed that pwMS have lower motor imagery of walking performance compared to healthy individuals, further work is necessary to examine how the disassociation between mental chronometry and actual performance relates to quality of life and well-being.

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“…Based on the multidimensional clinical assessment, we recently identified that the digits forward and backward, arithmetic and similarities were candidate endophenotypes in Caribbean families segregating ADHD. These tasks have been related to the phonological loop of working memory (digit forward), central executive working memory (digit backward), and working memory episodic buffer (arithmetic and similarities) [61][62][63], which correspond to working memory components [32,64,65]. Furthermore, neuropsychological tasks such as the completion of figures and the assembly of objects, which would assess visual detail detection, spatial object orientation, and visuospatial problem-solving cognitive domains, constitute endophenotypes of working memory and perceptual organization based on a hierarchical model of functions [49,[66][67][68] (Table 1).…”

Section: Endophenotypesmentioning

confidence: 99%

ADGRL3, FGF1 and DRD4: Linkage and Association with Working Memory and Perceptual Organization Candidate Endophenotypes in ADHD

et al. 2021

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Attention deficit hyperactivity disorder (ADHD) is a highly heritable neurobehavioral disorder that affects children worldwide, with detrimental long-term consequences in affected individuals. ADHD-affected patients display visual–motor and visuospatial abilities and skills that depart from those exhibited by non-affected individuals and struggle with perceptual organization, which might partially explain impulsive responses. Endophenotypes (quantifiable or dimensional constructs that are closely related to the root cause of the disease) might provide a more powerful and objective framework for dissecting the underlying neurobiology of ADHD than that of categories offered by the syndromic classification. In here, we explore the potential presence of the linkage and association of single-nucleotide polymorphisms (SNPs), harbored in genes implicated in the etiology of ADHD (ADGRL3, DRD4, and FGF1), with cognitive endophenotypes related to working memory and perceptual organization in 113 nuclear families. These families were ascertained from a geographical area of the Caribbean coast, in the north of Colombia, where the community is characterized by its ethnic diversity and differential gene pool. We found a significant association and linkage of markers ADGRL3-rs1565902, DRD4-rs916457 and FGF1-rs2282794 to neuropsychological tasks outlining working memory and perceptual organization such as performance in the digits forward and backward, arithmetic, similarities, the completion of figures and the assembly of objects. Our results provide strong support to understand ADHD as a combination of working memory and perceptual organization deficits and highlight the importance of the genetic background shaping the neurobiology, clinical complexity, and physiopathology of ADHD. Further, this study supplements new information regarding an ethnically diverse community with a vast African American contribution, where ADHD studies are scarce.

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Working memory profiles of patients with multiple sclerosis: Where does the impairment lie?

Cited by 11 publications

References 72 publications

Working Memory Deficits in Multiple Sclerosis: An Overview of the Findings

Working Memory Deficits in Multiple Sclerosis: An Overview of the Findings

Motor Imagery of Walking in People Living with and without Multiple Sclerosis: A Cross-Sectional Comparison of Mental Chronometry

ADGRL3, FGF1 and DRD4: Linkage and Association with Working Memory and Perceptual Organization Candidate Endophenotypes in ADHD

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