ADGRL3, FGF1 and DRD4: Linkage and Association with Working Memory and Perceptual Organization Candidate Endophenotypes in ADHD

Cervantes-Henríquez, Martha L; Acosta-López, Johan E.; Ahmad, Mostapha; Sánchez-Rojas, Manuel; Figueroa, Giomar Jiménez; Pineda-Alhucema, Wilmar; Martínez-Banfi, Martha; Noguera-Machacón, Luz M; Mejía-Segura, Elsy; Hoz, Moisés De La; Arcos-Holzinger, Mauricio; Piñeda, David; Puentes-Rozo, Pedro J.; Arcos‐Burgos, Mauricio; Vélez, Jorge I.

doi:10.3390/brainsci11070854

Cited by 4 publications

(5 citation statements)

References 164 publications

(229 reference statements)

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“…Besides, DRD4 -rs916457 has been linked with abnormal neuropsychological tasks outlining working memory and perceptual organization in ADHD patients ( Cervantes-Henriquez et al, 2021 ). The DRD4 -521 C/T SNP regulates the transcription rate and expression for DRD4 which affects the level of dopamine in the brain ( Zhang et al, 2021a ).…”

Section: Resultsmentioning

confidence: 99%

“…TAR RNA Binding Protein 1 ( TARBP1) DNA methylation is related to ADHD symptoms in adulthood and childhood ( Weiß et al, 2021 ). ADGRL3 -rs1565902 is linked with ADHD in the Caribbean population ( Cervantes-Henriquez et al, 2021 ). Atrophilin-3 [LPHN3; or ADGRL (3)] is a synaptic adhesion G protein-coupled receptor that binds to fibronectin leucine rich transmembrane protein 3 and teneurin-3 (FLRT3 and TEN-3) ( Regan et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

“…A null mutation of Lphn3 (KO) in Sprague-Dawley rats was related to hyperactivity and striatal changes in dopamine markers ( Regan et al, 2019 ). Fibroblast Growth Factor 1 (FGF1) -rs2282794 has been reported to relate to ADHD among the Caribbean population too ( Cervantes-Henriquez et al, 2021 ). Monoamine Oxidase A (MAO) is encoded by the MAOA gene and is highly expressed in the frontal cortex, responsible for the oxidation of neurotransmitters and dietary amines including serotonin, norepinephrine, and dopamine.…”

Section: Resultsmentioning

confidence: 99%

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Attention-deficit/hyperactive disorder updates

Kessi

Duan

Xiong

et al. 2022

Front. Mol. Neurosci.

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BackgroundAttention-deficit/hyperactive disorder (ADHD) is a neurodevelopmental disorder that commonly occurs in children with a prevalence ranging from 3.4 to 7.2%. It profoundly affects academic achievement, well-being, and social interactions. As a result, this disorder is of high cost to both individuals and society. Despite the availability of knowledge regarding the mechanisms of ADHD, the pathogenesis is not clear, hence, the existence of many challenges especially in making correct early diagnosis and provision of accurate management.ObjectivesWe aimed to review the pathogenic pathways of ADHD in children. The major focus was to provide an update on the reported etiologies in humans, animal models, modulators, therapies, mechanisms, epigenetic changes, and the interaction between genetic and environmental factors.MethodsReferences for this review were identified through a systematic search in PubMed by using special keywords for all years until January 2022.ResultsSeveral genes have been reported to associate with ADHD: DRD1, DRD2, DRD4, DAT1, TPH2, HTR1A, HTR1B, SLC6A4, HTR2A, DBH, NET1, ADRA2A, ADRA2C, CHRNA4, CHRNA7, GAD1, GRM1, GRM5, GRM7, GRM8, TARBP1, ADGRL3, FGF1, MAOA, BDNF, SNAP25, STX1A, ATXN7, and SORCS2. Some of these genes have evidence both from human beings and animal models, while others have evidence in either humans or animal models only. Notably, most of these animal models are knockout and do not generate the genetic alteration of the patients. Besides, some of the gene polymorphisms reported differ according to the ethnic groups. The majority of the available animal models are related to the dopaminergic pathway. Epigenetic changes including SUMOylation, methylation, and acetylation have been reported in genes related to the dopaminergic pathway.ConclusionThe dopaminergic pathway remains to be crucial in the pathogenesis of ADHD. It can be affected by environmental factors and other pathways. Nevertheless, it is still unclear how environmental factors relate to all neurotransmitter pathways; thus, more studies are needed. Although several genes have been related to ADHD, there are few animal model studies on the majority of the genes, and they do not generate the genetic alteration of the patients. More animal models and epigenetic studies are required.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Attention-deficit/hyperactive disorder updates

Kessi

Duan

Xiong

et al. 2022

Front. Mol. Neurosci.

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“…Currently, our research group studies the differential expression of ncRNA in subjects with Alzheimer's disease compared to healthy subjects. We also plan to study the exosomal load in patients with attention deficit-hyperactivity disorder [359][360][361][362][363][364] and HIV and Huntington's disease [365,366]. Funding: This study was financed by MINCIENCIAS, project "Nuevos ARN no codificantes exosomales y su papel en la patogénesis de la Enfermedad de Alzheimer", code 121584468097, grant 844/2019, contract 416-2020, awarded to Grupo en Genética y Medicina Molecular and Grupo de Productividad y Competitividad, Universidad del Norte, Barranquilla, Colombia.…”

Section: Discussionmentioning

confidence: 99%

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

et al. 2021

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Exosomes are extracellular vesicles released by cells, both constitutively and after cell activation, and are present in different types of biological fluid. Exosomes are involved in the pathogenesis of diseases, such as cancer, neurodegenerative diseases, pregnancy disorders and cardiovascular diseases, and have emerged as potential non-invasive biomarkers for the detection, prognosis and therapeutics of a myriad of diseases. In this review, we describe recent advances related to the regulatory mechanisms of exosome biogenesis, release and molecular composition, as well as their role in health and disease, and their potential use as disease biomarkers and therapeutic targets. In addition, the advantages and disadvantages of their main isolation methods, characterization and cargo analysis, as well as the experimental methods used for exosome-mediated drug delivery, are discussed. Finally, we present potential perspectives for the use of exosomes in future clinical practice.

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“…e dopamine D4 receptor is involved in transmitting neural signals to the brain's mesolimbic system, which regulates emotions and complex behavior (Wang et al, 2017). e association of single nucleotide polymorphisms (SNPs) of the DRD4 gene with the functioning of working memory and perception was shown in a study on a South American family-based sample (Cervantes-Henriquez et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Recognition of Emotional and Neutral Visual Scenes in Carriers of the MAOA, COMT, DRD4, and 5HT2A Gene Polymorphisms

Ермаков¹,

Vorobyeva²,

Denisova³

et al. 2022

Psych. Rus.

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Background. It is known that some genes regulate neurochemical metabolism, and their polymorphisms a" ect cognitive performance, including the ability to categorize emotionally signi# cant information. Objective. ! e aim of our study was to analyze the recognition of emotional and neutral visual scenes in carriers of di" erent polymorphic variants of the MAOA, COMT, DRD4, and 5HT2A genes. Design. ! e study sample consisted of 87 university students (Caucasians, women 63%, average age 20.4±2.6 years). ! e genotypes of the COMT, 5HT2A, and DRD4 genes were determined by polymerase chain reaction. Agarose gel electrophoresis was used to determine the number of tandem repeats of the MAOA gene. ! ree hundred sixty (360) photographic images of scenes of di" erent emotional valence (positive, negative, and neutral — 120 images for each category) were used as stimuli. ! ese images were classi# ed by expert assessments. ! e images were presented in a random sequence. ! e exposure time was 700 ms. ! e research participants were asked to determine the emotional valence of each scene. Results. We found that only the COMT gene genotype a" ected the recognition of emotional and neutral visual scenes. Carriers of the COMT Val/Val genotype, which causes dopamine to stay in the synaptic space for a shorter time, are better in recognizing and demonstrate higher sensitivity to the emotional content of scenes. Carriers of the Val/Met genotype demonstrated the worst ability to di" erentiate the emotional valence of visual scenes. Conclusion. ! is study has shown that the length of stay of monoamines in the synaptic space regulated by the COMT gene a" ects the recognition of emotional visual information.

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ADGRL3, FGF1 and DRD4: Linkage and Association with Working Memory and Perceptual Organization Candidate Endophenotypes in ADHD

Cited by 4 publications

References 164 publications

Attention-deficit/hyperactive disorder updates

Attention-deficit/hyperactive disorder updates

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

Recognition of Emotional and Neutral Visual Scenes in Carriers of the MAOA, COMT, DRD4, and 5HT2A Gene Polymorphisms

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