Work in the textile industry in Spain and bladder cancer

Serra, Consol; Kogevinas, Manolis; Silverman, Debra T.; Turuguet, D; Tardón, Adonina; García-Closas, Reina; Carrato, Alfredo; Castaño‐Vinyals, Gemma; Fernández, Francisco Pedro García; Stewart, Patricia A.; Benavides, Fernando G.; González, Silvia Tamez; Serra, Antoni; Rothman, Nathaniel; Malats, Núria; Dosemeci, Mustafa

doi:10.1136/oem.2007.035667

Cited by 23 publications

(16 citation statements)

References 34 publications

(26 reference statements)

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“…The excess risk observed among operators of these types of machines is consistent with several previous studies 17 40–42. Chemicals used in spinning and weaving areas have included mineral oils, polymers and sizing agents 42 43…”

Section: Discussionmentioning

confidence: 99%

Occupation and bladder cancer in a population-based case–control study in Northern New England

Colt

Karagas

Schwenn³

et al. 2010

Occup Environ Med

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Objectives We used data from a large, population-based case-control study in New England to examine relationships between occupation, industry, and bladder cancer risk. Methods Lifetime occupational histories were obtained by personal interview from 1,158 patients newly diagnosed with urothelial carcinoma of the bladder between 2001 and 2004 among residents of Maine, New Hampshire, and Vermont, and from 1,402 population controls selected from Department of Motor Vehicle records (ages 30 to 64 years) or Medicare beneficiary records (65 to 79 years). Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for demographic factors, smoking, and employment in high-risk occupations other than the one being analyzed. Results Male precision metalworkers and metalworking/plasticworking machine operators had significantly elevated risks and significant trends in risk with duration of employment (precision metalworkers: OR=2.2; CI: 1.4, 3.4, Ptrend =0.0065; metalworking/plasticworking machine operators: OR=1.6; CI: 1.01, 2.6, Ptrend=0.047). Other occupations/industries for which risk increased significantly with duration of employment included: for men, textile machine operators, mechanics/repairers, automobile mechanics, plumbers, computer systems analysts, information clerks, and landscape and horticultural services industry workers; and for women, service occupations, health services, cleaning and building services, management-related occupations, electronic components and accessories manufacturing, and transportation equipment manufacturing. Men reporting use of metalworking fluids (MWF) had a significantly elevated bladder cancer risk (OR=1.7; 95% CI: 1.1, 2.5), Conclusions Our findings for metalworkers and for MWF exposure support the hypothesis that some component(s) of MWF may be carcinogenic to the bladder in humans. Our results also corroborate many other previously-reported associations between bladder cancer risk and various occupations. More detailed analyses using information collected in job-specific questionnaires administered in this study may help to identify components of MWF that may be carcinogenic, and other bladder carcinogens to which people are exposed in a variety of occupations.

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Section: Discussionmentioning

confidence: 99%

Occupation and bladder cancer in a population-based case–control study in Northern New England

Colt

Karagas

Schwenn³

et al. 2010

Occup Environ Med

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“…In the present study, we did not find excess bladder cancer risks associated with work in the textile industry for either men (OR 1.1; 95% CI 0.7 to 1.9) or women (OR 1.2; 95% CI 0.4 to 4.4). Using more detailed exposure information collected through the textile exposure module incorporated into our CAPI interview, Serra et al 38 identified excess bladder cancer risks for loom weavers (OR 1.8; 95% CI 0.8 to 3.8), those working in winding, warping and sizing (OR 4.1; 95% CI 1.6 to 10.7), those exposed to synthetic fibres (OR 1.9; 95% CI 1.0 to 3.6) and those exposed to cotton materials (OR 1.5; 95% CI 0.9 to 2.4). These risks increased with employment duration, tended to be higher in women, and were similar after restricting the analysis to participants who never smoked.…”

Section: Discussionmentioning

confidence: 99%

Occupation and bladder cancer in a hospital-based case–control study in Spain

et al. 2007

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Objectives: We investigated the association between occupation and bladder cancer in a hospital-based casecontrol study conducted in Spain. Methods: 1219 patients with transitional cell carcinoma of the urinary bladder and 1271 controls selected from 18 hospitals in Spain between June 1998 and September 2000 provided detailed information on life-time occupational history, smoking habits, medical history, and other factors. We used unconditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for each occupation and industry, adjusting for age, hospital region, smoking duration, and employment in a high-risk occupation for bladder cancer. Results: Statistically significant increased risks were observed among men employed as machine operators in the printing industry (OR 5.4; 95% CI 1.6 to 17.7), among men employed in the transportation equipment industry (OR 1.6; 95% CI 1.1 to 2.6) and among those who had worked for >10 years in the electrical/gas/sanitary services (OR 3.9; 95% CI 1.5 to 10.4) and in hotels and other lodgings (OR 3.1; 95% CI 1.3 to 7.3). Men who worked as miscellaneous mechanics and repairers (OR 2.0; 95% CI 1.1 to 3.6) and as supervisors in production occupations (OR 2.1; 95% CI 1.2 to 3.6) also had excess risks for bladder cancer. Male farmers and those who worked in crop and livestock production had decreased risks for bladder cancer. We found no significant associations between occupation or industry and bladder cancer risk among women. Conclusions: We did not observe excess bladder cancer risk for many of the occupations identified as being a priori at high risk. Examination of more detailed job exposure information should help clarify these associations.Although more than 40 different occupations have been associated with an elevated risk of bladder cancer, the evidence for most occupations is unclear.

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“…33,34 The remainder mainly occurs in the squamous layer (SCaBER) of the bladder and manifests more commonly in developing countries. Hence, this study successfully designed varying PU:CNF composites for bladder prosthetic applications that may dually minimize the chance of cancer recurrence without hampering normal bladder cell growth.…”

Section: Discussionmentioning

confidence: 99%

Effects of Increasing Carbon Nanofiber Density in Polyurethane Composites for Inhibiting Bladder Cancer Cell Functions

Tsang

Chun²,

Im³

et al. 2011

Tissue Engineering Part A

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Polyurethane (PU) is a versatile elastomer that is commonly used in biomedical applications. In turn, materials derived from nanotechnology, specifically carbon nanofibers (CNFs), have received increasing attention for their potential use in biomedical applications. Recent studies have shown that the dispersion of CNFs in PU significantly enhances composite nanoscale surface roughness, tensile properties, and thermal stability. Although there have been studies concerning normal primary cell functions on such nanocomposites, there have been few studies detailing cancer cell responses. Since many patients who require bladder transplants have suffered from bladder cancer, the ideal bladder prosthetic material should not only promote normal primary human urothelial cell (HUC) function, but also inhibit the return of bladder cancerous cell activity. This study examined the correlation between transitional (UMUC) and squamous (or SCaBER) urothelial carcinoma cells and HUC on PU:CNF nanocomposites of varying PU and CNF weight ratios (from pure PU to 4:1 [PU:CNF volume ratios], 2:1, 1:1, 1:2, and 1:4 composites to pure CNF). Composites were characterized for mechanical properties, wettability, surface roughness, and chemical composition by atomic force microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, and goniometry. The adhesion and proliferation of UMUC and SCaBER cancer cells were assessed by MTS assays. Cellular responses were further quantified by measuring the amounts of nuclear mitotic protein 22 (NMP-22), vascular endothelial growth factor (VEGF), and tumor necrosis factor alpha. Results demonstrated that both UMUC and SCaBER cell proliferation rates decreased over time on substrates with increased CNF in PU. In addition, with the exception of VEGF from UMUC (which was the same across all materials), composites containing the most CNF activated cancer cells (UMUC and SCaBER) the least, as shown by their decreased expression of NMP-22, tumor necrosis factor alpha, and VEGF. Moreover, the adhesion of HUC increased on composites containing more CNF than PU. Overall levels of NMP-22 were significantly lower in HUC than in cancerous UMUC and SCaBER cells on PU:CNF composites. Thus, this study provided a novel nanocomposite consisting of CNF and PU that should be further studied for inhibiting the return of cancerous bladder tissue and for promoting normal non-cancerous bladder tissue formation.

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Work in the textile industry in Spain and bladder cancer

Cited by 23 publications

References 34 publications

Occupation and bladder cancer in a population-based case–control study in Northern New England

Occupation and bladder cancer in a population-based case–control study in Northern New England

Occupation and bladder cancer in a hospital-based case–control study in Spain

Effects of Increasing Carbon Nanofiber Density in Polyurethane Composites for Inhibiting Bladder Cancer Cell Functions

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