health psychology report • original article background Studying well-being at work and how it is related to employees' work-home interactions has been of great concern to both researchers and policy-makers in recent years. The aim of this study is to investigate the status of well-being at work of young Vietnamese employees working in Hanoi city and how dimensions of their work-home interaction contribute to their well-being at work. participants and procedure A self-administered questionnaire survey was conducted on 675 Vietnamese employees whose age was under 35 years. Demo and Paschoal's well-being at work scale and the Survey Work-Home Interaction-Nijmegen (SWING) scale were applied to measure employees' well-being at work and work-home interactions respectively. The control variables include employees' sex, marital status, working tenure, work position, mentoring, and type of organization. results This study documented differences in the status of wellbeing at work between groups by gender, work position, mentoring, whereas no difference was found between groups in age, marital status, working tenure or types of organization. Regression results demonstrated that altogether positive work-home, negative work-home, positive homework interactions and work position can explain quite well the variance of employees' well-being at work, and the predictive power of positive interaction for wellbeing at work was significantly stronger than that of work position and negative work-home interaction. conclusions Our results suggested that to promote employees' wellbeing at work, organizations should invest in boosting the positive interactions between work and home life of employees. Work position, gender issue and mentoring are also meaningful determinants of well-being at work.