Work Exposure to Urban Pollutants and Urinary Homovanillic Acid

Tomei, Francesco; Rosati, Maria Valeria; Ciarrocca, Manuela; Cherubini, Emilia; Baccolo, Tiziana Paola; Anzelmo, Vincenza; Tomao, Enrico

doi:10.1081/ese-120025840

Cited by 16 publications

(6 citation statements)

References 27 publications

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“…In our previous studies carried out on traffic police officers exposed to urban pollutants, we observed, besides the well-known effects on the cardiovascular and respiratory systems (Tomao et al, 2002;Tomei et al, 2004a;Volpino et al, 2004), the effects on the neuro-immuno-endocrine system, including the hypothalamic-pituitary-adrenocortical (HPA) axis and related systems. The results of these studies allow us to suggest that the alterations found in tested parameters, including growth hormone (GH), insulinlike factor type 1 (IGF-1), adrenocorticotropic hormone (ACTH), 5-hydroxyindolacetic acid (5-HIAA), cortisol, vasopressin, homovanillic acid (HVA), insulin, response of lympho-monocytes to phytohemagglutinin, serum levels of IgG anti-Herpes Simplex Virus Type 1 (IgG anti-HSV1), could be indicative of the early neuro-immune-endocrine system response to stressor present in the urban environment (Tomei et al, 2003a;Tomei et al, 2003b;Tomei et al, 2003c;Tomei, et al, 2003d;Tomei et al, 2004b;Tomei et al, 2004c;Tomei et al, 2004d;Tomei et al, 2004e;Tomei et al, 2004f;De Sio et al, 2005). Therefore, these parameters could be considered as early biological markers of chronic exposure to urban stressor.…”

Section: Introductionmentioning

confidence: 99%

Plasma dopamine in workers exposed to urban stressor

et al. 2007

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The aim of this study is to evaluate if the occupational exposure to urban stressor could cause alterations in dopamine (DA) plasma levels and related diseases in traffic police officers compared to a control group. After excluding subjects with principal confounding factors, 306 traffic police officers (139 female and 167 male) and 301 controls (134 female and 167 male) were included in the study. In traffic police officers, mean DA values were significantly higher compared with controls (P = 0.006 and P = 0.000 in male and female, respectively). The distribution of DA values in traffic police officers and controls was significant (P = 0.000 and P = 0.000 in male and female, respectively). The number of male traffic police officers with a positive response to the questionnaire's items concerning anxiety, depression and panic attacks was higher than controls, though not significant (7.2% traffic police officers versus 4.2% controls). This difference was also not significant in female traffic police officers compared with controls. According to our previous researches on other neuro-immune-endocrine parameters, DA could be used as an early biological marker, valuable for the group to be employed in occupational sets, even before the onset of pathology.

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Section: Introductionmentioning

confidence: 99%

Plasma dopamine in workers exposed to urban stressor

et al. 2007

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“…Quantification of high levels of urinary 5-HIAA is especially important in the diagnosis and follow-up of intestinal neuro-endocrine tumours, irritable bowel syndrome (8) and acute appendicitis (9). On the other hand, an important item of research shows that various occupational and environmental stressors may cause alterations in 5-HT turnover, leading to decreased urinary levels of 5-HIAA (10). Not surprisingly, low levels of 5-HIAA were found in the internal jugular vein following treatment of depression with SSRls, reflecting a reduction in CNS 5-HT release (11).…”

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confidence: 99%

Urinary Excretion of 5-Hydroxy-3-Indoleacetic Acid in Dystimic/Depressed, Adult Obese Women: What Correlations to Hepatic Steatosis?

Tarantino

Savastano

Colao

et al. 2011

Int J Immunopathol Pharmacol

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The synthesis of serotonin at eNS level is influenced by diet. Moreover, insulin resistance is associated with lower serotonin levels. Visceral obesity, strictly linked to hepatic steatosis is specifically associated with mild to severe somatic affective-depressive symptom clusters. Previous data support the view that depression involves serotonergic systems, reflecting low levels of urinary 5-hydroxy-3-indoleacetic acid (5-HIAA). The 24-h urinary excretion of 5-HIAA was evaluated in 76 dystimic/depressed, obese/ overweight females, divided into two groups, i.e., on a hyper-caloric diet, associated with a life style characterized by leisure time sedentary behavior (LTSB, 35 women), or on a normo-caloric diet, assisted by program-based strategies aimed at promoting physical activity participation (PAP, 41 women). Beck Depression Inventory (BDI) was carried out to score the severity of dystimia/depression. Anthropometric measures, metabolic indices, severity of hepatic steatosis at sonography and HOMA were studied. Urinary levels of 5-HIAA in controls and PAP groups were comparable with a great overlap, while in the LTSB group the urinary excretion of 5-HIAA was significantly reduced in respect to that of the PAP group and obviously compared to that of the control group, 3.4±1.4 mg/L versus 6.2±2.7 mg/L and 6.4±2.6 mg/L, respectively, ANOVA test, P= 0.001. Among metabolic indices, cholesterol, HDLcholesterol, triglycerides and uric acid were not able to predict urinary concentrations of 5-HIAA, which were not associated with hepatic steatosis; vice versa, ferritin levels, and mainly HOMA values, were independent predictors of the urinary excretion of 5-HIAA (P=O.235 and 0.45, respectively). Dystimia/ depression severity was negatively predicted by urinary 5-HIAA levels in the sense that the highest BDI values were forecast by the lowest values of urinary 5-HIAA (P= -O.72).The importance of measuring the 24-h urinary excretion of 5-HIAA in follow-ups could rely on a method simultaneously mirroring the well-being status, the adherence to physical activity, which leads to improved insulin sensitivity, and the eating habits acquired by dystimic/depressed overweight/obese patients. In contrast, the significance of the urinary 5-HIAA is reduced in evaluating the severity of hepatic steatosis, likely because it is a structured process.

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“…The effects of exposure to urban stressors on HPA axis were studied in our previous research; we observed significant differences in traffic policemen vs controls as to the following parameters: growth hormone (Tomei et al, 2003a), adrenocorticotropic hormone (Tomei et al, 2003b), cortisol (Tomei et al, 2003c), urinary homovanillic acid (Tomei et al, 2003d), insulin-like growth factor (Tomei et al, 2004a), prolactin (Tomei et al, 2006), androstenedione (Tomei et al, 2006b), dopamine (Tomei et al, 2007a), 17 a OH progesterone (Tomei et al, 2007b), follicle stimulating hormone ) and luteinizing hormone .…”

Section: Introductionmentioning

confidence: 98%

Professional exposure to urban stressors and effects on urinary metanephrines

Sancini

Tomei²,

Ciarrocca

et al. 2011

Toxicol Ind Health

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The aim of the study is to assess whether occupational exposure to urban stressors could cause alterations in urinary metanephrines levels in traffic policemen vs administrative staff of municipal police. A total of 258 subjects were included in the study: 129 traffic policemen exposed to urban stressors (68 males and 61 females) and 129 controls (68 males and 61 females). Urinary metanephrines mean levels were significantly higher in male traffic policemen compared to controls (p < 0.01). No significant differences were in female traffic policemen compared to controls. In the control group, urinary metanephrines mean levels were significantly higher in females compared to males (p < 0.01). There were no significant differences in urinary metanephrines mean levels in female traffic policemen vs male traffic policemen. The increase in urinary metanephrines mean levels observed in male exposed compared to controls could be related to chronic occupational exposure to low doses of chemical, physical and psychosocial urban stressors.

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Work Exposure to Urban Pollutants and Urinary Homovanillic Acid

Cited by 16 publications

References 27 publications

Plasma dopamine in workers exposed to urban stressor

Plasma dopamine in workers exposed to urban stressor

Urinary Excretion of 5-Hydroxy-3-Indoleacetic Acid in Dystimic/Depressed, Adult Obese Women: What Correlations to Hepatic Steatosis?

Professional exposure to urban stressors and effects on urinary metanephrines

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