Plasma dopamine in workers exposed to urban stressor

Tomei, Gianfranco; Capozzella, Assunta; Ciarrocca, Manuela; Fiore, Pina; Rosati, Maria Valeria; Fiaschetti, M.; Casale, T.; Anzelmo, Vincenza; Tomei, Francesco; Monti, Carlo

doi:10.1177/0748233707080043

Cited by 10 publications

(3 citation statements)

References 52 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DA in parallel with E and NE are elevated shortly after acute restraint stress, which immediately followed by the decrease of certain T and B lymphocyte subsets in lung and blood, followed by a substantial recovery within a few hours after release from stress [117]. Similar results observed in healthy volunteers (in good physical conditions) when exposed to repeated stress that caused significant increase of plasma DA levels [204]. • Environmental factors (overexposure to light, noise, urban stress, etc.)…”

Section: Acute and Chronic Stresssupporting

confidence: 68%

Role of Peripheral and Brain-Derived Dopamine (DA) in Immune Regulation

Tóth

Vecsernyés

Zelles

et al. 2012

Advances in Neuroimmune Biology

View full text Add to dashboard Cite

There is a well-defined influence of dopamine (DA) within the immune system. It can be synthesized not only in neurons, but also in immune cells, especially in T cells. In addition, these cell are bearing an active uptake mechanism, which could serve another source of DA. Therefore, it is highly likely that a functional DA-erg autocrine/paracrine regulatory loop exists, where lymphocytes-derived DA acting through its own receptors, also expressed on the same cells, can have an influence on its own function. However, the possibility that immune cell derived DA may act in accordance with DA secreted by other sources, i.e. from sympathetic terminals, cannot be ruled out. In harmony with these observations have provided evidences for the existence of a functional DA-erg system in the thymus, indicating that DA may have also a role in the maturation and selection of a certain subpopulation of lymphocytes as well. Based upon all of this information and evidences, for being able to summarize this topic, a much broader survey, including all direct and indirect immune-modulatory role of DA is required. Therefore, in this review we are going to discuss the most relevant aspects of this regulatory function. Facts and theories based upon experimental (pre-clinical) data are extended with the evidences accumulated by clinical observations.

show abstract

Section: Acute and Chronic Stresssupporting

confidence: 68%

Role of Peripheral and Brain-Derived Dopamine (DA) in Immune Regulation

Tóth

Vecsernyés

Zelles

et al. 2012

Advances in Neuroimmune Biology

View full text Add to dashboard Cite

show abstract

“…The effects of exposure to urban stressors on HPA axis were studied in our previous research; we observed significant differences in traffic policemen vs controls as to the following parameters: growth hormone (Tomei et al, 2003a), adrenocorticotropic hormone (Tomei et al, 2003b), cortisol (Tomei et al, 2003c), urinary homovanillic acid (Tomei et al, 2003d), insulin-like growth factor (Tomei et al, 2004a), prolactin (Tomei et al, 2006), androstenedione (Tomei et al, 2006b), dopamine (Tomei et al, 2007a), 17 a OH progesterone (Tomei et al, 2007b), follicle stimulating hormone ) and luteinizing hormone .…”

Section: Introductionmentioning

confidence: 98%

Professional exposure to urban stressors and effects on urinary metanephrines

Sancini

Tomei²,

Ciarrocca

et al. 2011

Toxicol Ind Health

Self Cite

View full text Add to dashboard Cite

The aim of the study is to assess whether occupational exposure to urban stressors could cause alterations in urinary metanephrines levels in traffic policemen vs administrative staff of municipal police. A total of 258 subjects were included in the study: 129 traffic policemen exposed to urban stressors (68 males and 61 females) and 129 controls (68 males and 61 females). Urinary metanephrines mean levels were significantly higher in male traffic policemen compared to controls (p < 0.01). No significant differences were in female traffic policemen compared to controls. In the control group, urinary metanephrines mean levels were significantly higher in females compared to males (p < 0.01). There were no significant differences in urinary metanephrines mean levels in female traffic policemen vs male traffic policemen. The increase in urinary metanephrines mean levels observed in male exposed compared to controls could be related to chronic occupational exposure to low doses of chemical, physical and psychosocial urban stressors.

show abstract

“…Lee et al (2010) related urinary catecholamines to work seniority, hypothesizing adaptation of employees to work-related stress. Plasma dopamine (Tomei et al, 2007) and urinary catecholamines (Sancini et al, 2011) were proposed as stress indicators in employees exposed to urban stressors such as air pollutants.…”

Section: Introductionmentioning

confidence: 99%

Sensitive profiling of biogenic amines in human urine by capillary electrophoresis with field amplified sample injection

Bacaloni

Insogna

Sancini

et al. 2013

Biomedical Chromatography

View full text Add to dashboard Cite

In order to monitor biogenic amines in human urine, a method based on field-amplified sample injection combined with capillary electrophoresis and direct UV absorption detection was developed. Dopamine, tyramine, tryptamine, serotonin and epinephrine were effectively separated and identified in human urine samples, and detection limits were 0.072, 0.010, 0.027, 0.010 and 0.120 µmol/L, respectively. Detection limits comparable to laser-induced fluorescence detection or solid phase extraction combined with capillary electrophoresis were achieved. Parameters affecting electrophoretic system detection sensitivity were investigated. Optimal separation conditions were obtained using as background electrolyte a pH 6.5 mixture of 2-(morpholino)ethanesulfonic acid 20 mmol/L and 30 mmol/L phosphate buffer, containing 0.05% hydroxypropylcellulose and 10% v/v methanol. Injections of the sample solution were performed by applying a voltage of 12 kV for 50 s. Recovery and accuracy ranged between 89.4 and 94.9%, and 89 and 112%, respectively. The method was successfully applied on actual urine samples (from a healthy volunteer): target bioamine content was consistent with endogenous levels reported in the literature. The proposed method is simple, fast and inexpensive and can be conveniently employed in work-related stress studies. The affordability and noninvasive sampling of the method allow epidemiological studies on large number of exposed persons to be performed.

show abstract

Plasma dopamine in workers exposed to urban stressor

Cited by 10 publications

References 52 publications

Role of Peripheral and Brain-Derived Dopamine (DA) in Immune Regulation

Role of Peripheral and Brain-Derived Dopamine (DA) in Immune Regulation

Professional exposure to urban stressors and effects on urinary metanephrines

Sensitive profiling of biogenic amines in human urine by capillary electrophoresis with field amplified sample injection

Contact Info

Product

Resources

About