Women with combined adenomyosis and endometriosis on MRI have worse IVF/ICSI outcomes compared to adenomyosis and endometriosis alone: A matched retrospective cohort study

Rees, C.O.; Rupert, Iris A.M.; Consten, D.; Mischi, Massimo; Vliet, Huib A.A.M. van; Schoot, Benedictus C.

doi:10.1016/j.ejogrb.2022.02.026

Cited by 9 publications

(26 citation statements)

References 23 publications

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“…The age of participants ranged from 17 years to 51 years. In 14 studies, women were assessed for adenomyosis before undergoing ART 14–16,18,20,22–24,61,62,64,66–68 . Women underwent fresh ART cycles in seven studies 14,16,20,23,24,66,68 , frozen cycles in three studies 18,22,67 and frozen or fresh cycles in four studies 15,61,62,64 .…”

Section: Resultsmentioning

confidence: 99%

“…In 14 studies, women were assessed for adenomyosis before undergoing ART 14–16,18,20,22–24,61,62,64,66–68 . Women underwent fresh ART cycles in seven studies 14,16,20,23,24,66,68 , frozen cycles in three studies 18,22,67 and frozen or fresh cycles in four studies 15,61,62,64 . In seven studies, women with subfertility who were not undergoing ART cycles were assessed for adenomyosis 8,27,50,56,59,63,65 .…”

Section: Resultsmentioning

confidence: 99%

“…All of the 21 included studies reported on the prevalence of isolated adenomyosis among a total of 25 600 participants. Of these, 18 studies also reported on the prevalence of adenomyosis occurring concurrently with endometriosis 8,15,16,18,20,[22][23][24]27,50,59,[61][62][63][64][65][66]68 , eight reported on the prevalence of adenomyosis occurring concurrently with fibroids 8,20,23,24,27,[63][64][65] and nine reported on the prevalence of concomitant adenomyosis, fibroids and/or endometriosis 8,20,23,24,27,56,[63][64][65] . Tables 1 and 2 describe the characteristics of the included studies and present the prevalence of adenomyosis, respectively.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The MUSA consensus published in 2015 provides a standardized terminology for describing ultrasound features associated with adenomyosis 48 . Although all included studies which started recruitment or analysis after the publication of MUSA guidelines adopted the MUSA criteria to diagnose adenomyosis, the number of features required to establish 20 Hou (2020) 14 Higgins (2021) 24 Yan (2014) 23 193/5087 Zhang (2021) 67 Thalluri (2012) 62 Stanekova (2018) 18 Sharma (2019) 68 Salim (2012) 16 Maubon (2010) 15 95/648 Neal (2020) 22 166/1015 Puente (2016) 64 36/255 Rees (2022) 66 Martínez-Conejero (2011) 61 ART 19/227 Kunz (2005) 50 11/158 Naftalin (2012) 27 4/64 Orlov (2022) 59 0/65 Silva (2022) 63 No ART Subtotal (tau 2 = 0.12, I 2 = 99.43%, P < 0.01) Subtotal (tau 2 = 0.02, I 2 = 69.99%, P = 0.003) Heterogeneity between groups: P = 0.040 (tau 2 = 0.12, I 2 = 99.13%, P < 0.01) a diagnosis varied widely (Table 1) 22,24,59,63,65,67 . Though the MUSA criteria are based on a combination of 2D and 3D signs, two studies used only 2D features of MUSA criteria to diagnose adenomyosis 59,65 .…”

Section: Figurementioning

confidence: 99%

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Prevalence of adenomyosis in women with subfertility: systematic review and meta‐analysis

Mishra

Melo

Easter

et al. 2023

Ultrasound in Obstet & Gyne

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What are the novel findings of this work?This is the first systematic review to evaluate the prevalence of both isolated adenomyosis and adenomyosis with coexisting endometriosis and/or fibroids in women with subfertility. The pooled prevalence was 10% for isolated adenomyosis, 1% for adenomyosis with coexisting fibroids, 6% for adenomyosis with coexisting endometriosis and 7% for adenomyosis with endometriosis and/or fibroids. What are the clinical implications of this work?One in 10 women with subfertility have a diagnosis of isolated adenomyosis. However, it is potentially underdiagnosed because of a lack of adherence to standardized diagnostic criteria. Clinicians and researchers should use well-established diagnostic criteria, such as those proposed by the morphological uterus sonographic assessment (MUSA) statement, to report on adenomyosis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Prevalence of adenomyosis in women with subfertility: systematic review and meta‐analysis

Mishra

Melo

Easter

et al. 2023

Ultrasound in Obstet & Gyne

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“…1,70 In addition, women using assisted reproductive technologies with concomitant adenomyosis and endometriosis detected on MRI have worse obstetrical outcomes as compared to those women with only endometriosis or only adenomyosis. 71 The abnormal JZ associated with adenomyosis may alter the uterine peristaltic activity and thus affect obstetrical outcomes by impacting sperm transport and implantation. 72 The abnormal JZ and abnormal peristaltic activity can be visualized on MRI, although the direct link between the imaging findings and obstetrical outcomes needs further research.…”

Section: Correlation Of Clinical Features With Mri Findingsmentioning

confidence: 99%

MRI of Adenomyosis: Where Are We Today?

et al. 2022

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Purpose of Review: The purpose of this review is to (i) summarize the current literature regarding the role of magnetic resonance imaging (MRI) in diagnosing adenomyosis, (ii) examine how to integrate MRI phenotypes with clinical symptomatology and histological findings, (iii) review recent advances including proposed MRI classifications, (iv) discuss challenges and pitfalls of diagnosing adenomyosis, and (v) outline the future role of MRI in promoting a better understanding of the pathogenesis, diagnosis, and treatment options for patients with uterine adenomyosis. Recent Findings: Recent advances and the widespread use of MRI have provided new insights into adenomyosis and the range of imaging phenotypes encountered in this disorder. Summary: Direct and indirect MRI features allow for accurate non-invasive diagnosis of adenomyosis. Adenomyosis is a complex and poorly understood disorder with variable MRI phenotypes that may be correlated with different pathogeneses, clinical presentations, and patient outcomes. MRI is useful for the assessment of the extent of findings, to evaluate for concomitant gynecological conditions, and potentially can help with the selection and implementation of therapeutic options. Nevertheless, important gaps in knowledge remain. This is in part due to the lack of standardized criteria for reporting resulting in heterogeneous and conflicting data in the literature. Thus, there is an urgent need for a unified MRI reporting system incorporating standardized terminology for diagnosing adenomyosis and defining the various phenotypes.

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