Women’s Health Considerations for Lipid Management

Wild, Robert A.; Weedin, Elizabeth A.; Gill, Edward A.

doi:10.1016/j.ecl.2015.09.005

Cited by 5 publications

(10 citation statements)

References 35 publications

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“…Dyslipidemia usually occurs during the 3rd trimester of pregnancy and TG concentrations higher than 1000 mg/dL is observed in the cases with sever hyperlipidemia (1,2). Pancreatitis may also develop in patients with lower TG levels, such as the current study cases who developed pancreatitis with TG levels lower than 1000 mg/dL.…”

Section: Discussionmentioning

confidence: 96%

“…Obesity, diabetes, pregnancy, nephrotic syndrome, and hypothyroidism can induce acquired HTG (2,3). This metabolic disturbance has an important role in atherosclerosis (2). Moreover, it can increase cardiovascular events as well as increase in insulin resistance, coagulopathy, and endothelial damage.…”

Section: Introductionmentioning

confidence: 99%

“…HTG could be hereditary or acquired. Obesity, diabetes, pregnancy, nephrotic syndrome, and hypothyroidism can induce acquired HTG (2,3). This metabolic disturbance has an important role in atherosclerosis (2).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, it can increase cardiovascular events as well as increase in insulin resistance, coagulopathy, and endothelial damage. Acute pancreatitis is a complication of HTG (2,4). Pregnant females with the history of metabolic disorders are more prone to develop acute pancreatitis during pregnancy because of HTG (1,5).…”

Section: Introductionmentioning

confidence: 99%

“…High concentration of TG in mother provides enough substrate for fetus metabolism, when the blood glucose level is low. In addition, high concentration of low-density lipoprotein (LDL) helps steroidogenesis of placenta (2). HTG could be hereditary or acquired.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effect of Two Supplements on Gestational Hypertriglyceridemia: Report of Two Cases

Mirzaeean¹,

Pourhoseini²,

Esfahani³

et al. 2017

Women Health Bull

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Introduction: Hypertriglyceridemia (HTG) is a physiological condition of pregnancy. However, in some patients, it could be harmful due to possible complications such as pancreatitis. Treating this clinical condition during pregnancy is controversial as many drugs are not allowed in different trimesters. The current report discussed 2 cases of HTG and their outcomes during pregnancy. Case Presentation: The 1st patient had twin pregnancy and a "milky" blood sample raised suspicion on abnormal lipid profile (LP) during the pregnancy screening tests. There was a positive history of HTG and the available laboratory results showed triglyceride (TG) 3920 mg/dL, cholesterol (Chol) 1370 mg/dL, and normal amylase and lipase serum levels. The patient received daily LP and blood glucose monitoring as well as insulin, gemfibrozil, and fish oil prescription. In the 30th week of gestation, one of the fetuses was lost and a cesarean section, because of preterm uterine contractures, was performed. Mother and baby were discharged in good conditions. The 2nd patient presented with nausea, vomiting, and abdominal pain in the 22nd week of gestation. The patient had gestational diabetes without the history of HTG. Laboratory results were as follows: TG 878 mg/dL, Chol 249 mg/dL, amylase 251 U/L, and lipase 29 U/L. The patient was treated as pancreatitis induced by HTG. Therefore, gemfibrozil and fish oil were prescribed in addition to hydration and low fat diet. A healthy term baby was the result of pregnancy. Conclusions: Establishing prompt medical treatment and controlling comorbid conditions are essential in gestational HTG. Although there are controversial reports about using medications such as fibrates and fish oil, gemfibrozil and fish oil were recommended as an effective treatment for the patients with gestational HTG.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Two Supplements on Gestational Hypertriglyceridemia: Report of Two Cases

Mirzaeean¹,

Pourhoseini²,

Esfahani³

et al. 2017

Women Health Bull

View full text Add to dashboard Cite

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Probiotic intervention as a potential therapeutic for managing gestational disorders and improving pregnancy outcomes

Abbasi

Aghebati‐Maleki

Yousefi

2021

Journal of Reproductive Immunology

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Lipid Metabolism in Pregnancy Women with Hypothyroidism and Potential Influence on Pregnancy Outcome

Qin,

Wu,

Zang

et al. 2024

Journal of Lipids

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Thyroid hormone (TH) is essential for maintaining normal physiological processes during pregnancy, including the metabolism of energy materials in both the mother and fetus and the growth and development of fetal bone and nervous system. TH can act on the liver, fat, and other tissues and organs to participate in lipid synthesis and breakdown through multiple pathways. Consequently, abnormal thyroid function is often accompanied by lipid metabolism disorders. Both clinical and subclinical hypothyroidism, as well as dyslipidemia during pregnancy, have been shown to be associated with an increased risk of multiple adverse pregnancy outcomes. Recently, there has been an increased interest in studying the alteration of lipidomic and hypothyroidism (both clinical and subclinical hypothyroidism) during pregnancy. Studies have suggested that altered lipid molecules might be used as potential biomarker and associated with adverse maternal and neonatal outcome. Thus, we summarized the associations between lipid metabolism and clinical or subclinical hypothyroidism during pregnancy in this review. Then, we discussed the underlying mechanisms of thyroid dysfunction and lipid metabolism. In addition, we reviewed the possible effect of dyslipidemia on pregnancy and neonatal outcome. However, the relationship between hypothyroidism during pregnancy and changes in the lipid profile and how to intervene in the occurrence and development of adverse pregnancy outcomes require further study.

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Women’s Health Considerations for Lipid Management

Cited by 5 publications

References 35 publications

Effect of Two Supplements on Gestational Hypertriglyceridemia: Report of Two Cases

Effect of Two Supplements on Gestational Hypertriglyceridemia: Report of Two Cases

Probiotic intervention as a potential therapeutic for managing gestational disorders and improving pregnancy outcomes

Lipid Metabolism in Pregnancy Women with Hypothyroidism and Potential Influence on Pregnancy Outcome

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