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Background: In recent decades functional foods with ingredients comprise of probiotics, prebiotics and postbiotics have been gaining a lot of notice by scientists. Probiotics and postbiotics are usually applied in pharmaceutical formulations and/or commercial food-based products. These bioactive agents can be associated with host eukaryotic cells and have a key role in maintaining and restoring host health. Objective: The reviews describe the concept of postbiotics, their quality control and potential applications in pharmaceutical formulations and commercial food-based products for health promotion, prevention of disease and complementary treatment. Results: Despite the effectiveness of probiotic products, researchers have introduced the concept of postbiotic to optimize its beneficial effects as well as to meet the needs of consumers to provide a safe product. The finding of recent studies suggests that postbiotics might be appropriate alternative agents for live probiotic cells and can be applied in medical, veterinary and food practice to prevent and to treat some diseases, promote animal health status and develop functional foods. Conclusion: Presently scientific literature confirms that postbiotics, as potential alternative agents, may have superiority in terms of safety relative to their parent live cells, and due to their unique characteristics in terms of clinical, technological and economical can be applied as promising tools in the drug and food industry for developing health benefits, and therapeutic aims.

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HCT-116, Caco-2, and HCT-8 Suppresses the Wnt/β-catenin signaling pathway and modulate the gut microbiota composition 32

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